Corneal transplantation in the United Kingdom and Republic of Ireland.

Vail, Andy; Gore, Sheila M.; Ba, Bradley; Easty, D L; Rogers, Chris

doi:10.1136/bjo.77.10.650

Cited by 44 publications

(24 citation statements)

References 2 publications

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“…In our study, the morphology of the donors' central corneal endothelial cell has been traced for an average of 5.4 years after PKP to assess the longevity of the transplanted grafts. Relatively few reports have been made to study at least 5-year-graft survival including detailed donor endothelial data as is present in our study [2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 91%

“…Patients with a history of contact lens wear were excluded from this study. At follow-up visits, after using tetracaine hydrochloride as topical anaesthesia, central corneal endothelial photographs were taken of three different central areas of the recommended sample size of 50-100 cells with a contact specular microscope (EM 1200, Tomey, Tennenlohe, Germany) [2][3][4]. The mean central endothelial cell density (ECD) and the coefficient of variation of endothelial cell size describing polymegethism were calculated with the built-in image analysis software (v. 1.5.1) of the device.…”

Section: Methodsmentioning

confidence: 99%

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Assessment of endothelial cell density and corneal thickness in corneal grafts an average of 5 years after penetrating keratoplasty

Kettesy

Németh

Kemény-Beke

et al. 2014

Wien Klin Wochenschr

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SummaryBackground Corneal transparency is a useful indicator for corneal function. Our aim was to investigate central corneal endothelial cells and corneal thickness in transplanted corneas at an average of 5.4 years after penetrating keratoplastyPatients and methods The study involved 68 perforated keratoplasty patients with at least a 1 year followup. Post-operatively, the central corneal endothelial layer was observed using a contact specular microscope. Central endothelial cell density, corneal thickness and the coefficient of variation of endothelial size were statistically analysed.Results The post-operative follow-up time was ranging from 12 months to 23 years. Endothelial cell density (ECD) was 1,501 ± 249 cell/mm 2 . The average cell size was 673.6 ± 98.3 μm 2 , and the coefficient of variation of cell size was 0.61 ± 0.11. No difference in ECD was detected between diagnostic groups. Corneal thickness was 0.56 ± 0.06 mm. Correlation between ECD and post-operative time was not significant (r = 0.02; p = 0.85).Conclusion Our study concluded that ECD showed a higher rate of decrease after penetrating keratoplasty with no relation to pre-operative diagnosis.Keywords Endothelial cell loss · graft survival · penetrating keratoplasty · specular microscope Bestimmung der Endothelzelldichte und der Hornhautdicke in Hornhauttransplantaten circa 5 Jahre nach einer penetrierenden Keratoplastik Zusammenfassung Hintergrund Die Transparenz der Cornea ist ein nütz-licher Indikator der Funktion der Hornhaut. Das Ziel unserer Studie war es, die zentralen Endothelzellen der Cornea sowie die Dicke der Hornhaut in transplantierten Hornhäuten circa 5,4 (im Durchschnitt) Jahre nach penetrierender Keratoplastik zu untersuchen.Patienten und Methoden In die Studie wurden 68 Patienten nach perforierter Keratoplastik aufgenommen, die zumindest 1 Jahr nachuntersucht worden waren. Postoperativ wurde die zentrale Endothelschicht der Hornhautmittel seines Kontakt-Spekular Mikroskops untersucht. Die Dichte der zentralen Endothelzellen, die Dicke der Hornhaut und der Variations-Koeffizient der Größe des Endothels wurden statistisch analysiert.Ergebnisse Der Zeitpunkt der postoperativen Kontrollen variierte von 12 Monaten bis 23 Jahren. Die Endothelzelldichte (EZD) lag bei 1501 ± 249 Zelle/mm 2 . Der Mittelwert der Zellgröße war 673,6 ± 98,3 μm 2 und der Variationskoeffizient 0,61 ± 0,11. Es gab keinen Unterschied in der EZD zwischen den nach Diagnosen eingeteilten Gruppen. Die Korrelation zwischen der EZD und dem Zeitabstand zur Operation war nicht kant (r = 0,02; p = 0,85).Schlussfolgerung Unsere Studie zeigt unabhängig von der präoperativen Diagnose eine abfallende Tendenz der EZD nach penetrierender Keratoplastik.

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Section: Introductionmentioning

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Assessment of endothelial cell density and corneal thickness in corneal grafts an average of 5 years after penetrating keratoplasty

Kettesy

Németh

Kemény-Beke

et al. 2014

Wien Klin Wochenschr

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“…1,2,26 Therefore, the alteration of the endothelial cell co's modified Eagle's medium (DMEM), Hanks' balanced genome may have therapeutic potential in diverse corsalt solution (HBSS), foetal calf serum (FCS), l-glutamine, neal diseases and vector-mediated local expression of penicillin and streptomycin were purchased from Gibco immunomodulatory molecules may have widespread BRL (Paisley, UK). Caesium chloride and X-gal were application in clinical transplantation.…”

Section: Day After Infection (C) Was Removed and Incubated With B71 mentioning

confidence: 99%

Ex vivo adenovirus-mediated gene transfer and immunomodulatory protein production in human cornea

et al. 1997

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“…[1][2][3][4][5][6][7][8][9][10] An important trend associated with improvements in cataract surgery techniques and the introduction of intraocular lenses has been a decline in aphakic bullous keratopathy (ABK) and an increase in pseudophakic bullous keratopathy (PBK). 8,[11][12][13][14] After cataract surgery techniques evolved and phacoemulsification technology improved in the 1990s, pseudophakic corneal oedema rates have decreased.…”

Section: Trends In Corneal Transplant Surgerymentioning

confidence: 99%

Management of patients with combined glaucoma and corneal transplant surgery

Banitt

Lee

2009

Eye

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Penetrating keratoplasty (PKP) is associated with an increased risk of secondary glaucoma. The development of glaucoma after PKP is an important risk factor for decreased corneal graft survival. The incidence of glaucoma after corneal transplant as well as the mechanism of developing increased intraocular pressure is reviewed in this paper. Treatments for post-PKP glaucoma include medications, laser, and surgery. The most frequent surgical glaucoma intervention is implantation of a glaucomadrainage device. Recent advances in corneal transplantation surgery may help to decrease corneal failure and the risk of developing post-keratoplasty glaucoma.

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Corneal transplantation in the United Kingdom and Republic of Ireland.

Cited by 44 publications

References 2 publications

Assessment of endothelial cell density and corneal thickness in corneal grafts an average of 5 years after penetrating keratoplasty

Assessment of endothelial cell density and corneal thickness in corneal grafts an average of 5 years after penetrating keratoplasty

Ex vivo adenovirus-mediated gene transfer and immunomodulatory protein production in human cornea

Management of patients with combined glaucoma and corneal transplant surgery

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