Corneal volume measures for monitoring contact lens induced corneal swelling: a pilot study

Lam, Andrew; Wong, Yin-Zhi; Cheng, Suk-yi

doi:10.1111/j.1444-0938.2010.00517.x

Cited by 17 publications

(15 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further studies are needed to determine the repeatability of endothelial cell density in Fuchs dystrophy, and to determine the relationship between endothelial cell density and the CPTR. Corneal volume is another parameter that been used to measure changes in corneal edema, 26,27 but an isolated measurement of corneal volume has the same limitations as an isolated measurement of CCT.…”

Section: Discussionmentioning

confidence: 99%

Fuchs' Endothelial Corneal Dystrophy

et al. 2013

View full text Add to dashboard Cite

Purpose To assess inter-observer agreement between two corneal specialists grading Fuchs dystrophy clinically, and to determine if the corneal central to peripheral thickness ratio (CPTR) might be an alternative and objective metric of disease severity. Design Cross-sectional study. Participants Forty-five eyes (26 subjects) with mild and moderate Fuchs dystrophy, 73 eyes (60 subjects) with advanced Fuchs dystrophy, and 267 eyes (142 subjects) with normal corneas. Methods Corneas with Fuchs dystrophy were graded by two corneal specialists based on the confluence and area of guttae, and the presence or absence of edema. Central corneal thickness (CCT) and peripheral corneal thickness at 4 mm from the center (PCT4) were measured by using scanning-slit pachymetry. CPTR4 was the quotient of CCT and PCT4. Main Outcome Measures Inter-observer agreement for clinical grade; CPTR4. Results Inter-observer agreement for clinical grading of Fuchs dystrophy was moderate (κ=0.32, 95% confidence interval, 0.19-0.45). In normal corneas, CCT was not correlated with age (r= -0.10, p=0.28, n=267), PCT4 decreased with age (r= -0.33, p<0.001, n=254), and CPTR4 increased with age (r= 0.59, p<0.001, n=254). CCT was higher in Fuchs dystrophy (652 ± 61 μm, n=118) than in normal corneas (559 ± 31 μm, n=267, p<0.001). PCT4 was higher in Fuchs dystrophy (650 ± 51 μm, n=107) than in normal corneas (643 ± 43 μm, n=254, p<0.001 after adjusting thickness for age). CPTR4 was higher in advanced Fuchs dystrophy (1.03 ± 0.07, n=65) than in mild and moderate Fuchs dystrophy (0.95 ± 0.07, n=42, age-adjusted p<0.001), which in turn was higher than in normal corneas (0.87 ± 0.05, n=254, age-adjusted p<0.001). CPTR4 was highly correlated with clinical grade of Fuchs dystrophy (r=0.77, p<0.001, n=361). CPTR4 was repeatable (median coefficient of variation, 1.3%), and provided excellent discrimination between Fuchs dystrophy and normal (area under the receiver operator characteristic curve, 0.93). Conclusions Agreement between corneal specialists for the subjective and morphologic clinical grading of Fuchs dystrophy is only moderate. The corneal CPTR is an objective, repeatable, and possibly functional, metric of severity of Fuchs dystrophy that warrants further investigation to determine its role in monitoring disease progression and predicting the need for keratoplasty.

show abstract

Section: Discussionmentioning

confidence: 99%

Fuchs' Endothelial Corneal Dystrophy

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Several studies have shown that the Pentacam has excellent repeatability and reliability for measurements of both cornea (thickness, curvature, aberration and volume) and anterior chamber (depth and volume). In our study, the following cornea and anterior chamber parameters were evaluated with the Scheimpflug system: corneal curvature (front and back surface) maps, corneal volumes (the volume of cornea is calculated with corneal pachymetry software to evaluate the entire cornea in different rings around the apex: 3, 5, 7 or 10 mm), and aberrations (3rd‐, 4th‐ and higher order aberrations [HOAs]) of the anterior, posterior and total cornea.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of corneal changes with accommodation in young and presbyopic populations using Pentacam High Resolution Scheimpflug system

Liu

Guo

et al. 2012

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Central corneal thickness (CCT) is used to screen candidates for refractive surgery, in order to reduce the risk of postoperative ectasia [6]. CCT readings are also crucial for the detection of contact lens-induced edema and diagnosis of corneal diseases, such as keratoconus and glaucoma [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Reliability of a New Swept-Source Optical Coherence Tomography Biometer in Healthy Children, Adults, and Cataract Patients

Huang

Zhao

Savini

et al. 2020

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose. To comprehensively assess the reliability of a new optical biometer (IOLMaster 700), based on swept-source optical coherence tomography (SS-OCT) and comparison with a standard biometer (IOLMaster 500), in healthy children, adults, and cataract patients. Methods. A total of 301 eyes from 301 consecutive subjects were enrolled prospectively. Two experienced operators measured each eye three times consecutively with the IOLMaster 700. The axial length (AL), keratometry (K), anterior chamber depth (ACD), lens thickness (LT), central corneal thickness (CCT), and white-to-white (WTW) distance were recorded. Intraoperator repeatability and interoperator reproducibility of the IOLMaster 700 were analyzed using the test-retest (TRT), coefficients of variation (CoV), and intraclass correlation coefficients (ICCs). The agreement between the two devices was evaluated using the Bland–Altman method. Results. The repeatability and reproducibility of the SS-OCT optical biometer were high for all ocular biometry parameters in all groups, except for the WTW in cataract patients (TRT, 0.27–0.44 mm; ICC, 0.86–0.95). The reproducibility of averaged measurements from three consecutive readings (TRT : AL = 0.02 mm, CCT = 5.41 μm, ACD = 0.03 mm, LT = 0.03 mm, Km = 0.17 D, and WTW = 0.22 mm) was higher than the reproducibility of single measurements (TRT : AL = 0.04 mm, CCT = 7.43 μm, ACD = 0.06 mm, LT = 0.05 mm, Km = 0.26 D, and WTW = 0.35 mm) in the three groups. The consistency in the data between the two biometers was high, with narrow 95% LoAs in the three groups. Conclusion. Repeatability and reproducibility of the new SS-OCT optical biometer were excellent and consistent with that of the standard biometer with respect to healthy children, healthy adults, and cataract patients.

show abstract

Corneal volume measures for monitoring contact lens induced corneal swelling: a pilot study

Cited by 17 publications

References 11 publications

Fuchs' Endothelial Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Evaluation of corneal changes with accommodation in young and presbyopic populations using Pentacam High Resolution Scheimpflug system

Reliability of a New Swept-Source Optical Coherence Tomography Biometer in Healthy Children, Adults, and Cataract Patients

Contact Info

Product

Resources

About