Corneometric evaluation of skin moisture after application of 10% and 30% gluconolactone

Abstract

Dry skin very often accompanies other dermatoses. The condition is caused by a defect in the protective barrier of the skin, leading to a loss of water from the stratum corneum. Dry skin is rough to the touch, reddened and often accompanied by itching and susceptibility to secondary bacterial infections. [1][2][3][4] Epidermis moisturization is typically determined using a corneometer: the electric capacity of the upper layers is measured to a depth of about 10-20 μm. 5 The care of dry skin is mainly based on the use of emollients containing urea and ceramides. 6 In addition, both alpha-and polyhydroxy acids, such as lactic acid (LAC) and lactobionic acid (LA), are used in home care cosmetics, at lower concentrations, and in chemical peelings, in higher concentrations. 7 An increase in skin moisture, wrinkle reduction and improved skin elasticity were observed after a 3-month application of a preparation with 12% lactic acid. 8 As PHAs do not sensitize the skin to ultraviolet radiation, they can be safely used also in summer 7 and should not cause irritation, even in people with sensitive skin. 9 Many studies have found LA to have beneficial properties for the skin. The present study evaluated the potential of gluconolactone, a cyclic ester (lactone) derivative of d-gluconic acid. The aim of the study was to compare the effects of 10% and 30% gluconolactone solution on skin hydration level.

Split‐face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters

“…In our study, measurements with the Corneometer CM 825 probe, Courage (Courage + Khazaka electronic GmbH, Cologne, Germany) showed a significant increase in skin hydration following application of both techniques: gluconolactone in combination with oxybrasion and with superficial microneedling of the skin with the Derma Skin Pen. Previous in‐house studies of water‐oxygen microdermabrasion 5 and a series of treatments using two concentrations of gluconolactone 9 also reported an increase in hydration of the superficial layers of the skin. Gluconolactone has the property of “attracting” water molecules, which is due to the presence of as many as four hydroxyl groups in its structure: this substance acts as a humectant.…”

“…Gluconolactone (GLA) is a relatively new cosmetic ingredient that combines the properties of glucose (reduces diffusion and evaporation of water from the epidermis) and alpha‐hydroxy acids 9 . It is also similar to polyhydroxy acids: it does not cause irritation, redness or burning.…”

“…2,5,7,8 Gluconolactone (GLA) is a relatively new cosmetic ingredient that combines the properties of glucose (reduces diffusion and evaporation of water from the epidermis) and alpha-hydroxy acids. 9 It is also similar to polyhydroxy acids: it does not cause irritation, redness or burning. Gluconolactone increases skin hydration, has antiacne, soothing and antiaging properties; it protects elastin fibers from the degrading effects of ultraviolet radiation.…”

Dragon fruit-kiwi fermented beverage: In vitro digestion, untargeted metabolome analysis and anti-aging activity in Caenorhabditis elegans

“…Serotonin is a neurotransmitter in the central nervous system (CNS), involved in many central nervous system diseases, such as depression, anxiety, schizophrenia, obsessive-compulsive disorder, addiction, Parkinson’s disease, and peripheral organ diseases, such as gastrointestinal Disease, arrhythmia, high blood pressure ( 49 ). Gluconolactone combines with water to inhibit the loss of epidermal moisture and achieves the effect of retaining water and beautifying the skin ( 50 ). In addition, it can also reduce the number of inflamed and total lesions to improve acne in patients ( 51 ).…”

Efficacy and safety of a new peeling formulated with a pool of PHAs for the treatment of all skin types, even sensitive

“…Lactobionic acid represents a new generation of AHA that has a polyhydroxyl structure (so‐called polyhydroxyl acid); it has been proven to provide structural and smoothing benefits to the skin, thus providing multiple anti‐aging advantages. 12 …”