Cornstarch is less allergenic than corn flour in dogs and cats previously sensitized to corn

Self Cite

Background -Food allergy is a possible cause of atopic dermatitis (AD) in dogs; it is typically diagnosed following an eight-week elimination diet trial (EDT) and a provocation with the original diet. This lengthy procedure is difficult for owners and its interpretation may be unclear.Hypothesis/Objectives -To test the effect of prednisolone used in the first weeks of an EDT in order to reduce the total time period for diagnosis. The goal was to perform food challenges earlier than after the traditionally recommended eight weeks.Animals -Fifty-three dogs with AD were included in the study.Methods and materials -All dogs were fed a commercially available extensively hydrolyzed protein-based commercial pet food and treated with prednisolone for at least two weeks to control pruritus and inflammation. Dogs were challenged two weeks after prednisolone finished, provided that no flare had occurred. Dogs with relapsing signs were fed the hydrolyzate for at least eight weeks with or without further prednisolone treatment.Results -Ten of 53 dogs (19%) had no relapse after two weeks off prednisolone: they were subsequently challenged with their regular food, had a relapse of signs and were diagnosed with a food-induced AD within four to six weeks of starting the EDT. In the other dogs, signs remained uncontrolled without prednisolone or relapsed rapidly after its discontinuation: they were considered nonfood-allergic after an eight week EDT.Conclusion and clinical importance -This study demonstrates that a shorter EDT is possible if the allergic pruritus and inflammation are initially controlled with a short course of glucocorticoids. This shortened trial is likely to improve owner adherence and facilitate the diagnosis of food allergy.

Section: Discussionmentioning

confidence: 99%

The usefulness of short‐course prednisolone during the initial phase of an elimination diet trial in dogs with food‐induced atopic dermatitis

Favrot

Bizikova

Fischer

et al. 2019

Self Cite

“…Alternately, it is possible that some dogs suffering from CAFR may have been able to react to ingredients in the test diet. Previous studies have demonstrated minimal to no antibody binding to the chicken hydrolysate or hydrolysed corn starch in this diet . The diet does contain oils of different sources (coconut oil, soybean oil and fish oil).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated minimal to no antibody binding to the chicken hydrolysate or hydrolysed corn starch in this diet. 42,43 The diet does contain oils of different sources (coconut oil, soybean oil and fish oil). The refining process of oils for dietary consumption typically removes most protein from the oil, but trace concentrations may remain.…”

Section: Discussionmentioning

confidence: 99%

Serum IgE and IgG responses to dietary antigens in dogs with and without cutaneous adverse food reactions

Pucheu‐Haston

Mougeot²

2019

Background It is suspected that many canine cutaneous adverse food reactions (CAFR) are true immunological hypersensitivities; however, few specific dietary allergens have been identified. Objective To compare serum immunoglobulin (Ig)E and IgG reactivity to specific food antigens in privately owned dogs with and without CAFR. Animals Eighteen adult dogs with nonseasonal pruritus recruited from a hospital population. Methods and materials Dogs were fed an extensively hydrolysed poultry‐based diet exclusively for 12 weeks. Serum was collected at the beginning of the trial. Canine atopic dermatitis extent and severity index and pruritus Visual Analog Scale scoring were performed at the beginning and end of the trial. Immunoblotting was performed to identify IgE and/or IgG binding to specific proteins in beef, egg, milk, chicken, pork, soy and wheat extracts. Results A CAFR (defined as an unequivocal relapse of pruritus after dietary challenge) was diagnosed in 10 dogs, with 60% relapsing when fed chicken‐based diets. Binding of subjects’ IgG to almost all proteins in all extracts was seen regardless of reported dietary history. Few proteins were exclusively or predominantly bound by IgE in CAFR dogs. Exceptions included a 42 kDa band (chicken), a 52 kDa band (beef), a 46 kDa band (beef and milk) and a poorly defined high molecular weight protein or proteins (beef and milk). Conclusion This study demonstrated three protein bands and a poorly defined band predominantly recognized by sera from dogs with CAFR relative to non‐CAFR dog sera. Almost all proteins were bound by IgG in all dogs, suggesting prior exposure to unreported foods.

“…11 Proteins present in vegetables also can be recognised by the immune system, and starch rather than flour preferably should be contained in these foods. 12 Interestingly, one small in vitro study suggests that even hydrolysed diets could elicit an adverse response in cats comparable to that of their basal diet containing the same intact proteins. 13 Two studies report the use of hydrolysed diets for chronic vomiting and diarrhoea, inflammatory bowel disease and AFR with gastrointestinal signs, yet, to the authors' knowledge, there are no studies reporting the use of hydrolysed diets for the diagnosis of AFR in cats with dermatological signs.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The usefulness of a hydrolysed fish and rice starch elimination diet for the diagnosis of adverse food reactions in cats: an open clinical trial

Noli¹,

Beltrando

2021

Background -Diagnosis of adverse food reaction (AFR) is based on an eight week elimination diet (ED) and is confirmed by relapse upon re-challenge with the previously fed diet. Hydrolysed EDs are commonly used for this purpose.Objective -To evaluate the commercially available hydrolysed fish protein and rice starch ED Farmina UltraHypo (FUH) for the diagnosis of feline AFR.Animals -Thirty-two nonseasonally pruritic cats.Methods and materials -Pruritus was assessed with a new dual Visual Analog Scale, lesions with the Scoring Feline Allergic Dermatitis scale and Quality of Life with a validated questionnaire on days 0 and 56. Short-acting corticosteroids or oclacitinib were permitted during the first six weeks. Cats showing 50% pruritus and/or lesional improvement were separately challenged with their prior diet, fish and rice. Cats not responding to the study diet were fed another hydrolysed diet for two months.Results -Twenty-five cats completed the ED: four dropped out due to vomiting and/or diarrhoea, one owing to low palatability and two were lost to follow-up. In 17 cats, pruritus improved by >50% and these underwent dietary challenges. Of these, nine reacted to their prior diet and/or fish and/or rice and were diagnosed with AFR, while eight did not relapse (and a diagnosis of AFR was considered to be doubtful). Of the eight cats in which pruritus did not improve, four underwent a second ED with no improvement.Conclusion and clinical importance -FUH may be a useful ED for the diagnosis of feline AFR, even in cats reacting to fish or rice.