Corona sign: manifestation of peripheral corneal epithelial edema as a possible marker of the progression of corneal endothelial dysfunction

Hara, Yuko; Kobayashi, Takeshi; Zheng, Xiaodong; Suzuki, Takashi; Shiraishi, Atsushi; Ohashi, Yuichi

doi:10.1007/s10384-016-0459-8

Cited by 4 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another interesting study showed that adult endothelial cells were able to migrate in the human eye, supporting that endothelial cell in the donor graft can migrate toward the periphery of the host cornea [27,28]. The transplanted endothelium should compensate for the denuded area by migrating to the peripheral area (Fig 4) [28,29]. Thus, the decrease in ECD after DMEK could be attributed to the distribution of endothelial cells to the peripheral area, especially in BK eyes, although other factors could also play a role.…”

Section: Plos Onementioning

confidence: 87%

Factors associated with endothelial cell density loss post Descemet membrane endothelial keratoplasty for bullous keratopathy in Asia

et al. 2020

View full text Add to dashboard Cite

To investigate the factors associated with endothelial survival after Descemet's membrane endothelial keratoplasty (DMEK) in eyes of Asian patients with bullous keratopathy (BK). Methods In this retrospective, consecutive interventional case series, 72 eyes of 72 patients who underwent DMEK were evaluated. Best corrected visual acuity (BCVA) and corneal endothelial cell density (ECD) were assessed at 12 months postoperatively. Multiple regression analysis was performed to assess parameters such as age, sex, axial length, preoperative visual acuity, re-bubbling, the ratio of graft to cornea area, iris damage scores, types of filling gases, air or SF 6 volume in the anterior chamber (AC) on postoperative day 1, and ECD loss rates at 12 months postoperatively. Results BCVA improved significantly at 12 months after DMEK (P < .001). The rate of ECD loss at 12 months after DMEK was 54.4 ± 16.1%. Multiple linear regression analysis showed that a larger ratio of graft to corneal area (P = 0.0061) and higher donor ECD (P = 0.042) were the primary factors for a lower ECD loss rate at 12 months after DMEK. Conclusion A relatively larger graft size compared to the host cornea and more donor ECD might help endothelial survival in patients with BK. Moreover, for such patients, the surgeon should

show abstract

Section: Plos Onementioning

confidence: 87%

Factors associated with endothelial cell density loss post Descemet membrane endothelial keratoplasty for bullous keratopathy in Asia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…This postoperative optical abnormality might be a limitation in some eyes after DMEK. Inoue et al reported a swirling pattern of horizontal water migration in the cornea in human and rabbit eyes,[ 24 , 25 ] which is identical to the anatomic pattern of the corneal nerve. Because DMEK replaces dysfunctional endothelium, key factors in need of investigation include an uneven distribution of endothelial cell density.…”

Section: Discussionmentioning

confidence: 97%

Topographic characteristics after Descemet’s membrane endothelial keratoplasty and Descemet’s stripping automated endothelial keratoplasty

et al. 2017

View full text Add to dashboard Cite

PurposeTo investigate the topographic characteristics of the posterior corneal surface after Descemet’s endothelial membrane keratoplasty (DMEK) and Descemet’s stripping automated endothelial keratoplasty (DSAEK) and their effects on postoperative visual acuity.MethodsNineteen eyes of 19 patients after DMEK, 23 eyes of 23 patients after DSAEK, and 18 eyes of 18 control subjects were retrospectively analyzed. Best spectacle-corrected visual acuity (BSCVA), aberration factors (higher-order aberrations [HOAs], spherical aberrations [SAs], and coma aberrations [Comas] at 6.0 mm) were evaluated preoperatively and at 1, 3, and 6 months postoperatively. The posterior refractive pattern of the topography map was classified into 5 grades (0–5) (posterior color grade) using anterior segment optical coherence tomography. Correlations between BSCVA and some factors (abbreviation factors, posterior color grade) were analyzed.ResultsBSCVA was significantly better after DMEK than after DSAEK (P < 0.001). Posterior HOAs, SAs, and Comas after each type of endothelial keratoplasty were significantly greater compared to control (P < 0.01). Posterior HOAs, total/anterior/posterior SAs, and posterior color grade were significantly lower in the DMEK group than in the DSAEK group at 3 months (P < 0.024 [posterior HOAs], P = 0.047 [total SA], P < 0.001 [anterior SAs], P = 0.021 [posterior SAs], and P < 0.001 [posterior color grade]) and 6 months postoperatively (P = 0.034 [posterior HOAs], P < 0.001 [total SAs], P < 0.001 [anterior SAs], P = 0.013 [posterior SAs], and P = 0.004 [posterior color grade]). BSCVA was significantly correlated with HOAs, SAs, and posterior color grade (P < 0.001 for all except anterior HOAs [P = 0.004]).ConclusionsHigh posterior color grades were associated with larger aberration factors and had a negative effect on visual function after endothelial keratoplasty. Rapid improvement of visual function after DMEK may be attributed to less change at the posterior surface.

show abstract

Is the Corneal Thickness Profile Altered in Diabetes Mellitus?

Ramm¹,

Spoerl²,

Pillunat³

et al. 2020

Current Eye Research

View full text Add to dashboard Cite

Corona sign: manifestation of peripheral corneal epithelial edema as a possible marker of the progression of corneal endothelial dysfunction

Abstract: The slit-lamp microscopic findings of the corona-like epithelial edema in the peripheral cornea are associated with the stage of corneal endothelial function. To support this, the developmental mechanism of the corona sign was demonstrated experimentally.

Cited by 4 publications

References 18 publications

Factors associated with endothelial cell density loss post Descemet membrane endothelial keratoplasty for bullous keratopathy in Asia

Factors associated with endothelial cell density loss post Descemet membrane endothelial keratoplasty for bullous keratopathy in Asia

Topographic characteristics after Descemet’s membrane endothelial keratoplasty and Descemet’s stripping automated endothelial keratoplasty

Is the Corneal Thickness Profile Altered in Diabetes Mellitus?

Contact Info

Product

Resources

About