Coronary angiographic profile characteristics in young patients with acute coronary syndrome and comparison with older patients with acute coronary syndrome

Maurya, Rakesh Kumar; Satish, Latha; Sanghvi, Sanjeev; Goutam, Kunal

doi:10.18203/2320-6012.ijrms20161201

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Similar to other studies, the majority of single-vessel CAD was in younger patients, while most multi-vessel CAD was more common in older patients. [ 17 , 20 ]…”

Section: Discussionmentioning

confidence: 99%

Age related differences in acute coronary syndrome: An observation at a central hospital in Vietnam

Anh

Minh

et al. 2021

Journal of Translational Internal Medicine

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Background and Objectives There is little data regarding the characteristics of young Vietnamese patients (<40 years old) who get acute coronary syndrome (ACS). This study aimed to compare the risk factors, clinical-subclinical characteristics, coronary lesions, and mortality prediction (based on the GRACE and TIMI scores) of young ACS patients with their older counterparts. Methods A cross-sectional descriptive study was conducted amongst 69 patients with ACS at the Cardiovascular Center of Hue Central Hospital from May 2017 to December 2018. These patients were divided into two groups: 33 patients were < 40 years old (group 1), and 36 patients were ≥ 40 years old (group 2). Demographic data, risk factors profile, clinical-subclinical characteristics, coronary lesions, and mortality prediction were compared between the two groups. Results Compared with group 2, group 1 had a higher proportion of severe angina (the prevalence of angina graded III-IV by CCS classification was 69.7% in group 1 versus 36.1% in group 2, P = 0.0108) and lower systolic pressure (median was 120 mmHg in group 1 versus 135 mmHg in group 2, P = 0.006). The prevalence of unstable angina and STEMI was higher in group 1 (51.5% and 36.4% in group 1 versus 30.6% and 11.1% in group 2, respectively), while NSTEMI was higher in group 2 (58.3% in group 2 versus 12.1% in group 1, P = 0.0002). The prevalence of single-vessel CAD, normal coronary angiography (CAG), nonobstructive CAD in group 1 was also higher and multi-vessel CAD was lower than group 2 (45.5%, 33.3%, 12.1% and 9.1% in group 1 versus 33.3%, 2.8%, 2.8% and 61.2% in group 2, respectively). The Gensini, GRACE, and TIMI scores were lower in group 1 (median was 5; medium was 78.55 and median was 2 in group 1 versus 37.5, 130.22 and 3 in group 2, respectively). Smoking was a risk factor for obstructive CAD in group 1 (OR = 7.12, 95% CI: 1.25–40.63, P < 0.05). Conclusion Young patients with ACS tended to be males, smokers, and with positive familial history; the grade of angina was more severe, and systolic pressure was lower; the prevalence of unstable angina and STEMI was higher. Smoking was a risk factor for obstructive CAD in young patients.

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“…Similar to other studies, the majority of single-vessel CAD was in younger patients, while most multi-vessel CAD was more common in older patients. [ 17 , 20 ]…”

Section: Discussionmentioning

confidence: 99%

Age related differences in acute coronary syndrome: An observation at a central hospital in Vietnam

Anh

Minh

et al. 2021

Journal of Translational Internal Medicine

View full text Add to dashboard Cite

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Study of Risk Factors, Clinical, Laboratory, Coronary Lesion Characteristics of Acute Coronary Syndrome in Patients Under 40 Years Old

Van

Anh

2020

JMP

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Background: There is little data regarding the characteristics of young (< 40 years old) Vienamese who get acute coronary syndrome patients. The aim of this study was to compare some risk factors, clinical, laboratory, coronary lesion characteristics and predicting mortality according to the GRACE and TIMI scores of young acute coronary syndrome (CAD) patients compared with their older counterparts. Materials and method: The cross – sectional descriptive study of 69 patients with acute coronary syndrome at the Interventional Cardiovascular Center of Hue Central Hospital and Hue University of Medicine and Pharmacy Hospital from May 2017 to December 2018. These patients were divided into two groups: 33 patients were aged < 40 years (group 1) and 36 patients were aged ≥ 40 years (group 2). Demographic characteristics, risk factors profile, clinical, laboratory, coronary lesion findings and predicting mortality were compared between the two groups. Results: Compared with group 2, the prevalence of male gender, smoking, family history of CAD were higher in group 1 and the prevalence of arterial hypertension, diabetes mellitus were lower (84.8%; 57.6%; 18.2% and 30.3%; 3.0% of group 1 vs 55.6%; 33.3%; 2.8% and 69.4%; 22.2% of group 2, respectively; p < 0.05). Group 1 had more severe angina (the prevalence of chest pain graded III-IV by CCS classification were 69,7% in group 1 vs 36.1% in group 2; p < 0.05) and lower systolic pressure (median was 120 mmHg in group 1 vs 135 mmHg in group 2; p < 0.05). The prevalence of unstable angina and STEMI were higher in group 1 (51.5% and 36.4% in group 1 vs 30.6% and 11.1% in group 2, respectively; p < 0.05), while NSTEMI was higher in group 2 (58.3% in group 2 vs 12.1% in group 1; p < 0.05). Group 1 had lower serum Glucose level but higher serum Creatinine level than group 2 (medians were 5.3 mmol/l and 80 µmol/l in group 1 vs 6.44 mmol/l and 72.5 µmol/l in group 2, respectively; p < 0.05). The prevalence of single vessel disease, angiographically normal coronary arteries, nonobstructive disease in group 1 were also higher and multi-vessel disease was lower than group 2 (45.5%; 33.3%; 12.1% and 9.1% in group 1 vs 33.3%; 2.8%; 2.8% and 61.2% in group 2; p < 0.05). The Gensini, GRACE and TIMI scores were lower in group 1 (median was 5; medium was 78.55 and median was 2 in group 1 vs 37.5; 130.22 and 3 in group 2, respectively; p < 0.05). Smoking was a risk factor for obstructed CAD in group 1 (OR = 7.12; 95% CI: 1.25 - 40.63; p < 0.05). Conclusion: Young patients with acute coronary syndrome tend to be male, smoking and positive familial history; grade of angina was more severe and systolic pressure was lower; the prevalence of unstable angina and STEMI were higher. In contrast, older patients had higher serum Glucose level and lower serum Creatinine level; the prevalence of multi-vessel disease was higher. The Gensini, GRACE and TIMI scores were lower in young patients. Smoking was a risk factor for obstructed CAD in young patients. Key words: CAD: acute coronary syndrome, 40 years old

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Coronary angiographic profile characteristics in young patients with acute coronary syndrome and comparison with older patients with acute coronary syndrome

Cited by 2 publications

References 11 publications

Age related differences in acute coronary syndrome: An observation at a central hospital in Vietnam

Age related differences in acute coronary syndrome: An observation at a central hospital in Vietnam

Study of Risk Factors, Clinical, Laboratory, Coronary Lesion Characteristics of Acute Coronary Syndrome in Patients Under 40 Years Old

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