Coronary Arteriosclerosis and Calcification in Infancy

Idiopathic arterial calcification in infancy

“…Attention has focussed mainly on coronary artery involvement (Brown & Richter 1941, Sladden 1952, Stryker 1946) with resultant myocardial ischaemia or frank infarction (Ravich & Rosenblatt 1947). This report concerns three infants with idiopathic arterial calcification seen at the Royal Hospital for Sick Children, Glasgow, over a period of 25 years.…”

Idiopathic arterial calcification in infancy

“…Sladden (1952) described 2 cases, and in 1957, Hunt and Leys added 2 cases occurring in sibs separated by 6 years, each being 4 weeks old at the time of death.…”

Idiopathic Arterial Calcification in Infancy

“…Field described focal swelling of the intercellular substance of the media of the common carotid artery as the earliest change in her case, with deposition of calcium in the media adjacent to the internal elastic lamina as a slightly later change. Stryker found the earliest change to be basophilic granulation, presumably calcification, of the elastica, and several other writers (Moran and Becker, 1959;Sladden, 1952) have pointed out that the first calcium deposits are laid down in relation to the internal elastic lamina-sometimes on either side of it.…”