Coronary artery atherosclerosis associated with shift work in chemical plant workers by using coronary CT angiography

Kang, WonYang; Park, Won-Ju; Jang, Keun-Ho; Kim, S.-H.; Gwon, Do-Hyeong; Lim, Hyeong-Min; Ahn, Ji-Sung; Moon, Jai-Dong

doi:10.1136/oemed-2015-103118

Cited by 16 publications

(9 citation statements)

References 28 publications

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“…As mentioned above, inflammation plays an important role in the initiation and progression of atherosclerosis. Recent studies, which have used imaging techniques to show increased carotid intima media thickness in shift workers compared to daytime workers and have evaluated coronary artery calcium scoring to show that coronary artery disease risk increases in shift workers, have provided direct evidence for the association between shift work and atherosclerosis [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Night shift work and inflammatory markers in male workers aged 20–39 in a display manufacturing company

Kim

Jang

Kwon

et al. 2016

Ann of Occup and Environ Med

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BackgroundThis study aimed to determine the association between shift work and inflammatory markers, which are independent risk factors of cardiovascular diseases, in male manual workers at a display manufacturing company.MethodsThis study was conducted between June 1 and July 31, 2015 on 244 male manual workers aged 20–39 years old at a display manufacturing company and investigated age, marital status, education level, alcohol consumption habit, smoking habit, regular exercise habit, sleep duration, sleep debt, sleep insufficiency, past medical history, current and past shift work experience, duration of shift work, and weekly work hours through face-to-face interviews using structured questionnaires and performed blood tests. Study participants were divided into daytime, former shift, and current shift workers based on the work schedule. Chi-square tests and one-way analyses of variance were performed to compare inflammatory markers and cardiovascular disease risk factors, and analyses of covariance were conducted after adjusting for variables potentially affecting inflammatory markers.ResultsHigh-sensitivity C-reactive protein (hs-CRP; mean ± standard deviation) levels in daytime, former shift, and current shift workers were 0.65 ± 0.43, 0.75 ± 0.43, and 0.86 ± 0.72 mg/L, respectively (p = 0.029). The leukocyte count (mean ± standard deviation) was 5,556 ± 1,123, 6,210 ± 1,366, and 6,530 ± 1,216 cells/μL, respectively (p < 0.001). Both hs-CRP level and leukocyte count were significantly higher in current shift workers than in daytime workers, and leukocyte count was higher in former shift workers than in daytime workers. After adjusting for variables potentially affecting inflammatory markers, hs-CRP levels (adjusted mean ± standard deviation) in daytime and current shift workers were 0.59 ± 0.06 and 0.92 ± 0.07 mg/L, respectively (p = 0.002). The leukocyte count (adjusted mean ± standard deviation) was 5,557 ± 124 and 6,498 ± 144 cells/μL, respectively (p < 0.001).ConclusionsA significant association between shift work and increases in inflammatory markers was confirmed. Because chronic low-grade inflammation plays an important role in the development of cardiovascular diseases, regular follow-up of inflammatory markers as a marker of cardiovascular diseases in shift workers may serve as an early indicator in predicting the effects of shift work on health.

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Section: Discussionmentioning

confidence: 99%

Night shift work and inflammatory markers in male workers aged 20–39 in a display manufacturing company

Kim

Jang

Kwon

et al. 2016

Ann of Occup and Environ Med

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“…We included 46 studies [10,17,23,24,37,38,40,41,43,45,[47][48][49][50][51][52][53][54][55][56][57][58][59]62,[65][66][67][68][69][70][71][73][74][75][76][77][78][79][80][81][82][83][84][85][86]91]. The overall SMD was − 0.08 (95CI − 0.12 to − 0.03; p = 0.001) with an important heterogeneity (I 2 = 85.9%) ( Fig.…”

Section: Meta-analysis Of Hdl Cholesterol For Each Type Of Shift Workmentioning

confidence: 99%

Shift work, and particularly permanent night shifts, promote dyslipidaemia: A systematic review and meta-analysis

et al. 2020

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“…These results were demonstrated in well-matched individuals who had similar baseline risk factors and were not shown to be influenced by the clinical status of the participants. To our knowledge, the only study attempting to examine the effect of shift work on CAD with the use of CCTA was recently done in 110 factory workers [15]. The results of this study showed that night shift workers suffered from a more extensive CAD burden than day shift workers.…”

Section: Discussionmentioning

confidence: 48%

Shift Work and the Risk of Coronary Artery Disease: A Cardiac Computed Tomography Angiography Study

Havakuk¹,

Zukerman²,

Flint³

et al. 2017

Cardiology

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Aims: Shift work disrupts the normal circadian rhythm and is associated with risk factors for coronary artery disease (CAD) and a higher incidence of CAD morbidity and mortality. Cardiac computed tomography angiography (CCTA) is a robust noninvasive modality for assessing the presence, extent, and severity of CAD. We sought to investigate whether shift workers are prone to a higher burden of CAD compared to non-shift workers. Methods: We conducted a historically prospective study in consecutive patients who underwent CCTA and answered a telephonic questionnaire. Due to significant differences in age and gender, we compared 89 well-matched pairs of shift workers and non-shift workers with the use of propensity scores. Results: Our cohort consisted of 349 participants, of whom 94 (26.9%) were shift workers. The mean age was 50.7 years, and 62.5% were males. After pairing, we showed that shift workers had a higher prevalence of CAD than non-shift workers (74.2 vs. 53.9%, respectively, p = 0.01), and a lower prevalence of coronary calcium scores of zero (46.8 vs. 63.4%, respectively, p = 0.034). Stenosis >50% was more prevalent in shift workers than in non-shift workers (20.2 vs. 11.2%, respectively, p = 0.006), and the extent of CAD (defined as the presence of ≥1-vessel disease) tended to be higher in shift workers than in non-shift workers (25.8 vs. 13.5%, respectively, p = 0.06). Conclusions: In this CCTA study, we showed in a well-matched cohort of consecutive patients that shift workers had a higher prevalence and extent of CAD than non-shift workers.

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Coronary artery atherosclerosis associated with shift work in chemical plant workers by using coronary CT angiography

Abstract: Shift work could induce CAD onset via the atherosclerotic process, and shift work employment duration was associated with an increased risk of atherosclerosis in male workers.

Cited by 16 publications

References 28 publications

Night shift work and inflammatory markers in male workers aged 20–39 in a display manufacturing company

Night shift work and inflammatory markers in male workers aged 20–39 in a display manufacturing company

Shift work, and particularly permanent night shifts, promote dyslipidaemia: A systematic review and meta-analysis

Shift Work and the Risk of Coronary Artery Disease: A Cardiac Computed Tomography Angiography Study

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