Coronary artery calcification burden, atherogenic index of plasma, and risk of adverse cardiovascular events in the general population: evidence from a mediation analysis

Yao, Haipeng; Feng, Guoquan; Liu, Yi; Chen, Yiliu; Shao, Chen; Wang, Zhongqun

doi:10.1186/s12944-024-02255-1

Lipids Health Dis

2024

DOI: 10.1186/s12944-024-02255-1

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Coronary artery calcification burden, atherogenic index of plasma, and risk of adverse cardiovascular events in the general population: evidence from a mediation analysis

Haipeng Yao,

Guoquan Feng,

Yi Liu

et al.

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From Cells to Plaques: The Molecular Pathways of Coronary Artery Calcification and Disease

Mitsis,

Khattab,

Christodoulou

et al. 2024

JCM

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Coronary artery calcification (CAC) is a hallmark of atherosclerosis and a critical factor in the development and progression of coronary artery disease (CAD). This review aims to address the complex pathophysiological mechanisms underlying CAC and its relationship with CAD. We examine the cellular and molecular processes that drive the formation of calcified plaques, highlighting the roles of inflammation, lipid accumulation, and smooth muscle cell proliferation. Additionally, we explore the genetic and environmental factors that contribute to the heterogeneity in CAC and CAD presentation among individuals. Understanding these intricate mechanisms is essential for developing targeted therapeutic strategies and improving diagnostic accuracy. By integrating current research findings, this review provides a comprehensive overview of the pathways linking CAC to CAD, offering insights into potential interventions to mitigate the burden of these interrelated conditions.

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From Cells to Plaques: The Molecular Pathways of Coronary Artery Calcification and Disease

Mitsis,

Khattab,

Christodoulou

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

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Coronary artery calcification burden, atherogenic index of plasma, and risk of adverse cardiovascular events in the general population: evidence from a mediation analysis

Cited by 1 publication

References 50 publications

From Cells to Plaques: The Molecular Pathways of Coronary Artery Calcification and Disease

From Cells to Plaques: The Molecular Pathways of Coronary Artery Calcification and Disease

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