Coronary artery calcification in women with syndrome X: usefulness of double-helical CT for detection.

Shemesh, Joseph; Fisman, Enrique Z.; Tenenbaum, Alexander; Apter, Sara; Leibovitch, L; Rath, Shmuel; Itzchak, Y; Motro, Michael

doi:10.1148/radiology.205.3.9393523

Cited by 21 publications

(7 citation statements)

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“…Due to higher risk factors and a lower number of infectious diseases, the percentage in industrialized countries is dramatically higher, e.g., 25.5% in Europe [1]. Due to higher risk factors and a lower number of infectious diseases, the percentage in industrialized countries is dramatically higher, e.g., 25.5% in Europe [1].…”

Section: Introductionmentioning

confidence: 99%

“…Despite their comparatively long scan times, even conventional CT scanners with rotation times of up to 1.5 s were used to quantify coronary calcium without making special arrangements to reduce motion artifacts [20,22,23,24,25,26]. Compared with the known high interscan variability of calcium scores for EBT and the Agatston score, these conventional approaches yielded similar results.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of calcium scoring performance in cardiac computed tomography

2002

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Electron beam tomography (EBT) has been used for cardiac diagnosis and the quantitative assessment of coronary calcium since the late 1980s. The introduction of mechanical multi-slice spiral CT (MSCT) scanners with shorter rotation times opened new possibilities of cardiac imaging with conventional CT scanners. The purpose of this work was to qualitatively and quantitatively evaluate the performance for EBT and MSCT for the task of coronary artery calcium imaging as a function of acquisition protocol, heart rate, spiral reconstruction algorithm (where applicable) and calcium scoring method. A cardiac CT semi-anthropomorphic phantom was designed and manufactured for the investigation of all relevant image quality parameters in cardiac CT. This phantom includes various test objects, some of which can be moved within the anthropomorphic phantom in a manner that mimics realistic heart motion. These tools were used to qualitatively and quantitatively demonstrate the accuracy of coronary calcium imaging using typical protocols for an electron beam (Evolution C-150XP, Imatron, South San Francisco, Calif.) and a 0.5-s four-slice spiral CT scanner (Sensation 4, Siemens, Erlangen, Germany). A special focus was put on the method of quantifying coronary calcium, and three scoring systems were evaluated (Agatston, vol-ume, and mass scoring). Good reproducibility in coronary calcium scoring is always the result of a combination of high temporal and spatial resolution; consequently, thin-slice protocols in combination with retrospective gating on MSCT scanners yielded the best results. The Agatston score was found to be the least reproducible scoring method. The hydroxyapatite mass, being better reproducible and comparable on different scanners and being a physical quantitative measure, appears to be the method of choice for future clinical studies. The hydroxyapatite mass is highly correlated to the Agatston score. The introduced phantoms can be used to quantitatively assess the performance characteristics of, for example, different scanners, reconstruction algorithms, and quantification methods in cardiac CT. This is especially important for quantitative tasks, such as the determination of the amount of calcium in the coronary arteries, to achieve high and constant quality in this field.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of calcium scoring performance in cardiac computed tomography

2002

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“…More than 50% of women with angina may have normal or near-normal coronary arteries visualized at coronary angiography, a rate much higher than is observed among men (1). Coronary angiography, however, is an insensitive measure of atherosclerosis burden (2), and some have hypothesized that subclinical atherosclerosis may promote microvascular dysfunction See page 74 and ischemia in women with angina in the absence of obstructive epicardial coronary disease (3). Presently, there are few data regarding the relationship between angina and subclinical atherosclerosis in women to evaluate this hypothesis.…”

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confidence: 99%

Clinical Characteristics, Vascular Function, and Inflammation in Women With Angina in the Absence of Coronary Atherosclerosis

Banks

Puttagunta

Murphy

et al. 2011

JACC: Cardiovascular Imaging

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angina among women in the general population is common and is not associated with subclinical atherosclerosis. Additionally, angina in the absence of subclinical atherosclerosis is not related to many traditional atherosclerotic risk factors but is associated with clinical, inflammatory, and vascular factors that reflect endothelial dysfunction and vascular stiffness, suggesting a distinct vascular etiology and alternative potential therapeutic targets.

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“…14 -16 There are also reports on utilization of EBCT to compare the coronary calcium in stable angina pectoris and first myocardial infarction, 17 to stratify patients presenting to the emergency department with chest pain, 18 and in detection of atherosclerosis in women with syndrome X. 19 However, the possible difference in coronary artery calcium between syndrome X and CAD patients has not been evaluated in aged men with chronic, stable angina, and the potential utility of EBCT in these patients has not been investigated to our knowledge. This study was then conducted to evaluate the coronary calcium scores (CCSs) in patients with chronic stable angina and evident myocardial ischemia, and to examine the possible usefulness of EBCT to differentiate syndrome X from CAD in these patients.…”

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confidence: 99%

Differential Coronary Calcification on Electron-Beam CT Between Syndrome X and Coronary Artery Disease in Patients With Chronic Stable Angina Pectoris

Chen

et al. 2001

Chest

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Coronary artery calcification in women with syndrome X: usefulness of double-helical CT for detection.

Abstract: Double-helical CT may be useful in detection of atherosclerosis in women with syndrome X who demonstrate normal coronary arteries at angiography.

Cited by 21 publications

References 0 publications

Assessment of calcium scoring performance in cardiac computed tomography

Assessment of calcium scoring performance in cardiac computed tomography

Clinical Characteristics, Vascular Function, and Inflammation in Women With Angina in the Absence of Coronary Atherosclerosis

Differential Coronary Calcification on Electron-Beam CT Between Syndrome X and Coronary Artery Disease in Patients With Chronic Stable Angina Pectoris

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