Coronary artery calcification score and common iliac artery calcification score in non‐dialysis <scp>CKD</scp> patients

Mizuiri, Sonoo; Nishizawa, Yuichiro; Yamashita, Kazuomi; Mizuno, Kenji; Ishine, Masahiro; Doi, Shigehiro; Takao, Masaki; Shigemoto, Kazuhiro

doi:10.1111/nep.13113

Cited by 12 publications

(12 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vascular calcification is a critical complication in patients with CKD. Calcification of arterioles within the endothelial and medial layers induces arterial stiffness and occlusion, which may cause coronary artery disease and calciphylaxis in peripheral vessels [2,3,4]. Therefore, vascular calcification is predictive of poor prognoses and clinical outcomes in CKD patients, such as overall mortality and even poor arteriovenous graft maturation [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Previous basic studies showed that the rate of ostelcalcin and MGP secretion increased after treatment with vitamin D. Fraser et al first noticed that the protein and mRNA expression of MGP in osteosarcoma cell line increased after 1.25(OH)2D treatment at the concentration of 0.3 nM for more than 48 h. They also found vitamin D can stimulate osteocalcin synthesis earlier and at lower vitamin D levels compared to MGP production. [3]. In osteoblasts, 1.25(OH)2D increases vitamin K-dependent binding protein-related osteocalcin expression, which could maintain the mineralization of osteoblasts into osteocytes [72,73].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Emerging Role of Vitamins D and K in Modulating Uremic Vascular Calcification: The Aspect of Passive Calcification

Hou

Zheng

et al. 2019

Nutrients

View full text Add to dashboard Cite

Vascular calcification is a critical complication in patients with chronic kidney disease (CKD) because it is predictive of cardiovascular events and mortality. In addition to the traditional mechanisms associated with endothelial dysfunction and the osteoblastic transformation of vascular smooth muscle cells (VSMCs), the regulation of calcification inhibitors, such as calciprotein particles (CPPs) and matrix vesicles plays a vital role in uremic vascular calcification in CKD patients because of the high prevalence of vitamin K deficiency. Vitamin K governs the gamma-carboxylation of matrix Gla protein (MGP) for inhibiting vascular calcification, and the vitamin D binding protein receptor is related to vitamin K gene expression. For patients with chronic kidney disease, adequate use of vitamin D supplements may play a role in vascular calcification through modulation of the calciprotein particles and matrix vesicles (MVs).

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emerging Role of Vitamins D and K in Modulating Uremic Vascular Calcification: The Aspect of Passive Calcification

Hou

Zheng

et al. 2019

Nutrients

View full text Add to dashboard Cite

show abstract

“…Likewise, the relatively small sample sizes of participants with CKD stage 1 and 5 ND may attenuate the association between kidney function and calcium scores. Moreover, reported patterns of independent risk factors for calcification differ with arterial sites in both CKD cohorts [27,36] and the general population [28,37,38]. Most likely, the inconsistent patterns reflect differences in the studied populations as well as different methods for registration of risk factors and diverging sensitivity of CT scanning protocols.…”

Section: Discussionmentioning

confidence: 99%

“…To date, few studies applying CT scans have assessed calcification beyond the coronary arteries. Mizuiri et al [27] reported calcification in both the coronary (81.4%) and iliac arteries (87.4%) in 145 individuals with a median age of 72 years, a median eGFR of 32 mL/min/1.73 m 2 and a high prevalence of diabetes and cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Regional distribution and severity of arterial calcification in patients with chronic kidney disease stages 1–5: a cross-sectional study of the Copenhagen chronic kidney disease cohort

et al. 2020

View full text Add to dashboard Cite

Background Patients with chronic kidney disease (CKD) and arterial calcification are considered at increased risk of adverse cardiovascular outcomes. However, the optimal site for measurement of arterial calcification has not been determined. The primary aim of this study was to examine the pattern of arterial calcification in different stages of CKD. Methods This was an observational, cross-sectional study that included 580 individuals with CKD stages 1–5 (no dialysis) from the Copenhagen CKD Cohort. Calcification of the carotid, coronary and iliac arteries, thoracic and abdominal aorta was assessed using non-contrast multidetector computed tomography scans and quantified according to the Agatston method. Based on the distribution of Agatston scores in the selected arterial region, the subjects were divided into calcium score categories of 0 (no calcification), 1–100, 101–400 and > 400. Results Participants with CKD stages 3–5 had the highest prevalence of calcification and the highest frequency of calcium scores > 400 in all arterial sites. Calcification in at least one arterial site was present in > 90% of patients with CKD stage 3. In all five CKD stages prevalence of calcification was greatest in both the thoracic and abdominal aorta, and in the iliac arteries. These arterial sites also showed the highest calcium scores. High calcium scores (> 400) in all five arterial regions were independently associated with prevalent cardiovascular disease. In multivariable analyses, after adjusting for cardiovascular risk factors, declining creatinine clearance was associated with increasing calcification of the coronary arteries (p = 0.012) and the thoracic aorta (p = 0.037) only. Conclusions Arterial calcification is highly prevalent throughout all five CKD stages and is most prominent in both the thoracic and abdominal aorta, and in the iliac arteries. Follow-up studies are needed to explore the potential of extracardiac calcification sites in prediction of cardiovascular events in the CKD population.

show abstract

“…Vascular calcification, which involves the deposition of calcifying particles within the endothelial layer or smooth muscle within the medial layer, is an important issue due to its associated complications, such as peripheral arterial occlusive disease and coronary artery disease [1][2][3]. Several conditions, including insulin resistance, hypertension, acute decompensated heart failure, chronic kidney disease (CKD), dyslipidemia, vitamin D deficiency, and metabolic syndrome, are associated with vascular calcification [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification

Hou

Zheng

et al. 2020

IJMS

View full text Add to dashboard Cite

Vascular calcification, which involves the deposition of calcifying particles within the arterial wall, is mediated by atherosclerosis, vascular smooth muscle cell osteoblastic changes, adventitial mesenchymal stem cell osteoblastic differentiation, and insufficiency of the calcification inhibitors. Recent observations implied a role for mesenchymal stem cells and endothelial progenitor cells in vascular calcification. Mesenchymal stem cells reside in the bone marrow and the adventitial layer of arteries. Endothelial progenitor cells that originate from the bone marrow are an important mechanism for repairing injured endothelial cells. Mesenchymal stem cells may differentiate osteogenically by inflammation or by specific stimuli, which can activate calcification. However, the bioactive substances secreted from mesenchymal stem cells have been shown to mitigate vascular calcification by suppressing inflammation, bone morphogenetic protein 2, and the Wingless-INT signal. Vitamin D deficiency may contribute to vascular calcification. Vitamin D supplement has been used to modulate the osteoblastic differentiation of mesenchymal stem cells and to lessen vascular injury by stimulating adhesion and migration of endothelial progenitor cells. This narrative review clarifies the role of mesenchymal stem cells and the possible role of vitamin D in the mechanisms of vascular calcification.

show abstract

Coronary artery calcification score and common iliac artery calcification score in non‐dialysis CKD patients

Cited by 12 publications

References 30 publications

Emerging Role of Vitamins D and K in Modulating Uremic Vascular Calcification: The Aspect of Passive Calcification

Emerging Role of Vitamins D and K in Modulating Uremic Vascular Calcification: The Aspect of Passive Calcification

Regional distribution and severity of arterial calcification in patients with chronic kidney disease stages 1–5: a cross-sectional study of the Copenhagen chronic kidney disease cohort

The Role of Vitamin D in Modulating Mesenchymal Stem Cells and Endothelial Progenitor Cells for Vascular Calcification

Contact Info

Product

Resources

About