Coronary Artery Calcium Progression Is Associated with Cardiovascular Events Among Asymptomatic Individuals: From the North Texas Primary Care Practice-based Research Network (NorTex-PBRN)

Cardarelli, Roberto; Hall, Alexandria; Rankin, Wade

doi:10.3122/jabfm.2017.05.170032

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…Of note, these relationships have not been reported before in this population. Finally, assessment of CAC score has many potential clinical applications: supplementing prognostic information for CHD, identifying subjects who may benefit from a more aggressive treatment and/or further diagnostic workup, and evaluating the efficacy of risk factor modification or medical treatments on plaque burden 38 .…”

Section: Discussionmentioning

confidence: 99%

Coronary Artery Calcium is Associated with LPA Gene Variant RS7765803-C in Mexican Mestizo Population. The GEA Project

Cardoso-Saldaña¹,

Posadas-Sánchez²,

González-Salazar³

et al. 2020

RIC

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Background: Lipoprotein(a) [Lp(a)] levels are genetically determined; high levels are a risk factor for coronary disease, although their association with coronary artery calcium (CAC) is controversial. Objective: The objective of the study was to assess the association of LPA gene polymorphisms with CAC in a Mexican Mestizo population. Methods: We included 1594 subjects 35-70 years old. Six polymorphisms of the LPA gene were analyzed. CAC score was determined by tomography and Lp(a) serum levels by immunonephelometry. The association of LPA polymorphism with CAC and Lp(a) was evaluated by logistic regression. Results: The prevalence of Lp(a) ≥30 mg/dL was 10%, and of CAC >0 was 26.9%. Three polymorphisms were associated with high Lp(a) levels: rs10455872-G (p = 0.013), rs6907156-T (p = 0.021), and rs7765803-C (p = 0.001).Homozygotes (CC) for the rs7765803 variant compared with the G allele (CG + GG) carriers had higher Lp(a) levels (8.9[3.3-23.9] vs. 4.9 [2.3-11.2] mg/dL; p = 0.015) and higher prevalence of CAC >0 (36.5% vs. 26.3%, p = 0.045) and were associated with CAC > 0 (odds ratio = 1.7, 95% confidence interval: 1.06-2.7; p < 0.026). The other polymorphisms were not associated with CAC. Conclusions: This is the first study to demonstrate in a Mexican Mestizo population that carriers of the rs7765803-C allele of LPA gene have 2.6 times greater risk for high Lp(a) values and 1.7 times higher risk for coronary artery disease. (REV INVEST CLIN. 2020;72(2):61-8)

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Section: Discussionmentioning

confidence: 99%

Coronary Artery Calcium is Associated with LPA Gene Variant RS7765803-C in Mexican Mestizo Population. The GEA Project

Cardoso-Saldaña¹,

Posadas-Sánchez²,

González-Salazar³

et al. 2020

RIC

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“…There has recently been much interest in the involvement of coronary artery calcium (CAC) in the process. CAC is closely related to age, sex, diabetes, hypertension, dyslipidemia, smoking, and metabolic syndrome (MS) [ 4 , 5 ], as well as elevated cardiovascular event risk [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Metabolic Syndrome and Clinical Outcome in Patients Treated with Drug-Eluting Stenting after Rotational Atherectomy for Complex Calcified Coronary Lesions

Xiao

Wang

et al. 2022

JCM

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Background and aims: although an association between metabolic syndrome (MS) and cardiovascular disease risk has been documented, the relationship in patients with complex calcified coronary lesions undergoing rotational atherectomy (RA) and drug-eluting stent(DES) insertion remains controversial. Here, the influence of MS on outcomes was assessed. Methods and results: we retrospectively included 398 patients who underwent RA and DES insertion for complex calcified coronary lesions in our institution between June 2015 and January 2019. The modified Adult Treatment Plan III was used to diagnose MS. The endpoint was major adverse cardiovascular events (MACEs), comprising mortality from all causes, myocardial infarction, and target vessel revascularization (TVR). In all, 173 (43.5%) patients had MS. MS was significantly associated with MACE over the 28.32 ± 6.79-month follow-up period (HR 1.783, 95% CI from 1.122 to 2.833) even after adjustment for other possible confounders. Conclusion: MS was frequently observed in patients treated with RA with DES insertion for complex calcified coronary lesions. MS independently predicted MACE in these patients.

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“…6 Cardarelli et al 7 report on the NorTex PBRN Study that addresses risk factors for coronary artery calcium (CAC) and to determine whether CAC progression independently predicts cardiovascular disease-related events. Although measurement of CAC progression is not ready to be adopted into routine practice, this biomarker could be used in the future to guide informed clinician-patient decision making regarding the intensity of risk factor management.…”

Section: Patient-level Improvementmentioning

confidence: 99%

Improving the Health of Patients and Communities: Evolving Practice-based Research (PBR) and Collaborations

Fiscella

2017

J Am Board Fam Med

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This issue illustrates how research from practice-based research networks has evolved to span a spectrum from improving patient-level care and practice quality to improving health within local and global communities. Articles address patient-level improvements (a biomarker for cardiovascular disease progression, late-onset anorexia nervosa, complementary health approaches used by patients, and patient preferences related to antibiotics for acute respiratory infections); practicelevel improvements (selection of types of fecal immunochemical tests, practice facilitation, practice registry implementation, community-based outreach, and bidirectional texting); and communitylevel improvements (primary care-public health partnership, influenza surveillance, and establishing family medicine training abroad). ( J Am Board Fam Med 2017;30:562-566.)

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Coronary Artery Calcium Progression Is Associated with Cardiovascular Events Among Asymptomatic Individuals: From the North Texas Primary Care Practice-based Research Network (NorTex-PBRN)

Cited by 6 publications

References 32 publications

Coronary Artery Calcium is Associated with LPA Gene Variant RS7765803-C in Mexican Mestizo Population. The GEA Project

Coronary Artery Calcium is Associated with LPA Gene Variant RS7765803-C in Mexican Mestizo Population. The GEA Project

Relationship between Metabolic Syndrome and Clinical Outcome in Patients Treated with Drug-Eluting Stenting after Rotational Atherectomy for Complex Calcified Coronary Lesions

Improving the Health of Patients and Communities: Evolving Practice-based Research (PBR) and Collaborations

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