Coronary artery disease and body mass index: What is the relationship?

Formentini, Franciane Silvana; Nagano, Francisca Eugenia Zaina; Neto, Francisco Diego Negrão Lopes; Adam, Eduardo Leal; Fortes, Fernanda Santos; Silva, Lannay Ferreira da

doi:10.1016/j.clnesp.2019.08.008

Cited by 12 publications

(6 citation statements)

References 15 publications

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“…Our study also shows the inverse effects of gIQ on healthrelated outcomes including BMI, smoking, T2D, hypertension, and a positive effect on HDL cholesterol, which are well-known for their influences on CAD risk [36][37][38][39][40]. Same as for CAD, these association signals appear to be largely mediated by measured intelligence and educational attainment.…”

Section: Discussionsupporting

confidence: 67%

Genetically determined intelligence and coronary artery disease risk

Pang

Zeng

et al. 2020

Clin Res Cardiol

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Background Epidemiological studies have shown inverse association between intelligence and coronary artery disease (CAD) risk, but the underlying mechanisms remain unclear. Methods Based on 242 SNPs independently associated with intelligence, we calculated the genetic intelligence score (gIQ) for participants from 10 CAD case-control studies (n = 34,083) and UK Biobank (n = 427,306). From UK Biobank, we extracted phenotypes including body mass index (BMI), type 2 diabetes (T2D), smoking, hypertension, HDL cholesterol, LDL cholesterol, measured intelligence score, and education attainment. To estimate the effects of gIQ on CAD and its related risk factors, regression analyses was applied. Next, we studied the mediatory roles of measured intelligence and educational attainment. Lastly, Mendelian randomization was performed to validate the findings. Results In CAD case-control studies, one standard deviation (SD) increase of gIQ was related to a 5% decrease of CAD risk (odds ratio [OR] of 0.95; 95% confidence interval [CI] 0.93 to 0.98; P = 4.93e-5), which was validated in UK Biobank (OR = 0.97; 95% CI 0.96 to 0.99; P = 6.4e-4). In UK Biobank, we also found significant inverse correlations between gIQ and risk factors of CAD including smoking, BMI, T2D, hypertension, and a positive correlation with HDL cholesterol. The association signals between gIQ and CAD as well as its risk factors got largely attenuated after the adjustment of measured intelligence and educational attainment. The causal role of intelligence in mediating CAD risk was confirmed by Mendelian randomization analyses. Conclusion Genetic components of intelligence affect measured intelligence and educational attainment, which subsequently affect the prevalence of CAD via a series of unfavorable risk factor profiles.

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Section: Discussionsupporting

confidence: 67%

Genetically determined intelligence and coronary artery disease risk

Pang

Zeng

et al. 2020

Clin Res Cardiol

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“…A previous study reported that BMI positively correlated with early incidence of coronary artery disease (CAD) and in patients diagnosed with CAD, increased BMI was positively associated with the presence of DM. 34 In our study, after propensity matching in which age or insulin use were entered, BMI was not significantly different between HP and non-HP lesions.…”

Section: Plaque Components On Oct In Hpsmentioning

confidence: 49%

Clinical Significance of Coronary Healed Plaques in Stable Angina Pectoris Patients Undergoing Percutaneous Coronary Intervention

Kimura

Isshiki

Shimizu

et al. 2023

Circ J

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Background: Coronary healed plaques (HPs) reportedly have high vulnerability or show advanced atherosclerosis and a risk of rapid plaque progression. However, the prognosis of stable angina pectoris (SAP) patients with HPs undergoing percutaneous coronary intervention (PCI) remains under-investigated. Methods and Results:We analyzed 417 consecutive lesions from SAP patients undergoing pre-and post-intervention optical coherence tomography (OCT) for which HPs were defined as having a layered appearance. We investigated the differences in clinical and lesion characteristics, and post-PCI outcomes between HPs and non-HPs. To account for differences in clinical characteristics, propensity score matching was performed between the groups. HPs were observed in 216 lesions (51.8%) in the total cohort. In the propensity-matched cohort (n=294), HPs had higher rates of angiographic-B2/C lesions (77.6% vs. 59.2%, P<0.001), OCT-lipid-rich plaques (40.8% vs. 25.9%, P=0.007), macrophages (78.2% vs. 44.2%, P<0.001), greater luminal area stenosis (73.5±11.0% vs. 71.5±10.3%, P=0.002), and a higher prevalence of post-stenting irregular tissue protrusion (45.1% vs. 14.7%, P<0.001) than non-HPs. In the total cohort, target lesion revascularization (TLR)-free survival was poorer for HPs (log-rank test 7.66; P=0.006), and Cox proportional hazards analysis showed HP as an independent predictor of TLR (hazard ratio, 5.98; 95% confidence interval, 1.72-20.82; P=0.005). Conclusions:In SAP patients, HPs had greater complexity of lesions and higher vulnerability, which may have contributed to the poorer post-PCI outcomes.

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“…And according to Formentini et al, (2019), both in adults and in the elderly, the increase in BMI is positively associated with the presence of DM, DLSP and SAH, that is, aggravating factors of CAD. However, the authors state that they did not find a direct association with the occurrence of CAD or its severity (FORMENTINI et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…BMI (HUANG et al, 2016;FORMENTINI et al, 2019), Geriatric Nutritional Risk Index (GNRI) (HUANG et al, 2016) Regarding the applicability of the Body Mass Index (BMI), since it allows the use of both the patient's estimated weight and height, it is more feasible to use. And according to Formentini et al, (2019), both in adults and in the elderly, the increase in BMI is positively associated with the presence of DM, DLSP and SAH, that is, aggravating factors of CAD. However, the authors state that they did not find a direct association with the occurrence of CAD or its severity (FORMENTINI et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Impact of nutritional status on the emergence of coronary obstructive diseases: Integrative review

Santos¹,

Cobra²

2023

Emerging Issues Related to the Corona Virus Pandemic (Covid 19)

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Introduction: The change in the nutritional profile of the Brazilian population brought about by changes in the structure of the diet of individuals, which correlates with economic, social, demographic and health-related changes, has led to the worsening of nutritional problems, since the state of malnutrition to obesity, which corroborates the increase in non-transmissible chronic diseases. Objective: To describe the effect of nutritional status on the occurrence of coronary artery disease. Methodology: integrative review, carried out through a bibliographic survey, in July and August 2022, in the Virtual Health Library (VHL), Scientific Electronic Library Online (SciELO), ScienceDirect, Scopus (Elsevier), U.S. National Library of Medicine National Institute of Health (PubMED) and Web of Science, with the Health Science Descriptors (DeCS) and their correspondents in Spanish and Portuguese: “Coronary Stenosis”, “Coronary Disease”, “Coronary Artery Disease”, “Coronary Occlusion” and “Nutritional Status”, for crossing the DeCS, the Boolean operators “OR” and “AND” were used. With regard to ethical aspects, all authors of the articles were respected. Results: 433 potentially eligible publications were identified, of which 13 were selected. These came from nine different nationalities. Of which 23.07% were published in the year 2021. Regarding the level of evidence of the studies, most (53.84%) were level III. Conclusion: In relation to this work, it was shown that the low intake of proteins, fibers, vitamins, minerals and high intake of carbohydrates and fats were associated with the increase and severity of CAD. Thus, the most prudent and scientifically viable thing is for the general population to consume a balanced diet rich in antioxidants from fresh fruits, vegetables and whole grains.

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Coronary artery disease and body mass index: What is the relationship?

Cited by 12 publications

References 15 publications

Genetically determined intelligence and coronary artery disease risk

Genetically determined intelligence and coronary artery disease risk

Clinical Significance of Coronary Healed Plaques in Stable Angina Pectoris Patients Undergoing Percutaneous Coronary Intervention

Impact of nutritional status on the emergence of coronary obstructive diseases: Integrative review

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