Coronary Artery Disease and Diabetes Mellitus

Aronson, Doron; Edelman, Elazer R.

doi:10.1016/j.ccl.2014.04.001

Cited by 176 publications

(152 citation statements)

References 114 publications

(110 reference statements)

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“…Diabetes is a significant predisposing factor for CAD, and CAD is a major determinant of the long‐term prognosis among patients with diabetes mellitus. Increased mortality rates are noted for CAD patients, especially after myocardial infarction, with worse overall prognosis . Diabetes mellitus is associated with a twofold to fourfold increase in mortality risk due to heart disease .…”

Section: Discussionmentioning

confidence: 73%

“…Increased mortality rates are noted for CAD patients, especially after myocardial infarction, with worse overall prognosis. 47 Diabetes mellitus is associated with a twofold to fourfold increase in mortality risk due to heart disease. 48 In the Framingham Heart Study , diabetic patients had a twofold to fourfold increased risk of all-causes and cardiovascular disease mortality.…”

Section: Discussionmentioning

confidence: 83%

See 1 more Smart Citation

Risk factors of premature coronary artery disease in Iran: A systematic review and meta‐analysis

Poorzand

Tsarouhas

Hozhabrossadati

et al. 2019

Eur J Clin Investigation

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Background The aim of this study was to determine the mean age at which coronary artery disease (CAD) hase decreased in recent years in Iran. This systematic review and meta‐analysis compares the prevalence of different risk factors of premature CAD (PCAD) in patients vs healthy individuals. Methods Medline, Web of Science, Embase and Scientific Information Database were searched for studies about PCAD risk factors in Iran until 28 October 2017. Observational studies of Iranians, comparing risk factors between patients with PCAD and age‐ and sex‐matched healthy subjects, were included. Fixed‐effects and random‐effects model were used for pooling data. Odds ratio (OR) with 95% CI and mean difference were used for effect size estimation among studies. Results Twelve studies were eligible for meta‐analysis. Diabetes mellitus (OR: 2.4, 95% CI: 1.9‐3.03; P = 0.0001, I2 = 25.5%; P = 0.2), family history of CAD (OR: 2.09, 95% CI: 1.22‐3.6; P = 0.007, I2 = 86%; P = 0.0001), dyslipidaemia (OR: 2.05, 95% CI: 1.15‐3.64; P = 0.01, I2 = 54%; P = 0.08), smoking (OR: 1.65, 95% CI: 1.11‐2.46; P = 0.01, I2 = 77.2%; P = 0.000) and hypertension (OR: 1.35, 95% CI: 1.21 to‐1.50; P < 0.001, I2 = 31%, P = 0.1) associated with PCAD. Sensitivity analysis demonstrated that patients with PCAD had significantly lower levels of high‐density lipoprotein (HDL) cholesterol and significantly higher levels of triglycerides compared to healthy subjects (MD: −2.56, 95% CI: −3.54 to −1.58, P < 0.001, I2 = 42%, P = 0.01 and MD: 21.17, 95% CI: 14.73‐27.62, P < 0.001, I2 = 80.12%, P < 0.001, respectively). It should be noted that although high levels of heterogeneity in LDL and HDL values among the studies were observed, when dyslipidaemia was studied as a binary variable, no significant heterogeneity among studies was observed. Conclusion Diabetes mellitus, family history of CAD, dyslipidaemia, smoking, and hypertension were significantly and positively associated with CAD in young adults compared to healthy age‐ and sex‐matched population in Iran.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 83%

Risk factors of premature coronary artery disease in Iran: A systematic review and meta‐analysis

Poorzand

Tsarouhas

Hozhabrossadati

et al. 2019

Eur J Clin Investigation

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“…Coronary artery disease (CAD), which includes angina, myocardial infarction, and sudden cardiac death, is the predominant cause of morbidity and mortality (Haffner, Lehto, Rönnemaa, Pyörälä, & Laakso, ; Wong, ). Diabetes mellitus (DM), especial type 2 DM, which is closely associated with clustered risk factors, such as hypertension, hypercholesterolemia, obesity, and smoking, can show a two‐ to fourfolds mortality risk for CAD (Aronson & Edelman, ; Beller et al, ). Although there has been considerable progress in the diagnosis and treatment for CAD and its complications, coronary event rates remain high among patients with DM2 (Preis et al, ).…”

Section: Introductionmentioning

confidence: 99%

Circulating miR‐130 and its target PPAR‐γ may be potential biomarkers in patients of coronary artery disease with type 2 diabetes mellitus

Yuan

Peng

Liu

et al. 2019

Molec Gen & Gen Med

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Background Patients of coronary artery disease (CAD) with type 2 diabetes mellitus (DM2) show increased mortality risk than CAD patients without DM2, while few biomarkers can be used to discriminate them. Methods Fifty‐nine patients of CAD with DM2 (DM2‐CAD group), 79 patients of CAD without DM2 (CAD group), and 63 healthy control subjects were recruited. Circulating miR‐130 (miR‐130a and miR‐130b) and PPAR‐γ (peroxisome proliferator‐activated receptor gamma) were measured and their Pearson correlation was analyzed. 3′ UTR binding prediction and luciferase assay were used to determine the target relationship between miR‐130 and PPAR‐γ. Receiver operating characteristics (ROC) analysis was performed to test the discrimination ability of miR‐130 between DM2‐CAD and CAD groups. Results miR‐130a and miR‐130b showed decreased expression in DM2‐CAD group when compared with the CAD group and health control. Both bioinformatics and luciferase assays showed that miR‐130 could bind the 3′ UTR of PPAR‐γ. Furthermore, miR‐130 negatively correlated with PPAR‐γ in both CAD and DM2‐CAD group in Pearson's coefficient analysis. Both miR‐130a and miR‐130b were able to discriminate DM2‐CAD group from CAD group and control subjects. Conclusion Circulating miR‐130 may regulate the expression of PPAR‐γ and can be used as a biomarker to discriminate DM2‐CAD from CAD.

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“…One of the major risk factors for cardiovascular disease is diabetes mellitus, even near controlled blood sugar doesn't seem to reduce these cardiovascular events. This is true for type 2 diabetes mellitus, which carries a very poor outcome in cases of coronary artery disease despite the presence of different modalities of treatments like percutaneous coronary intervention, and coronary artery bypass graft surgery [3], [4]. Blood supply of the heart is composed of right and left coronary arteries arising from right and left coronary sinuses respectively, the RCA gives small branches and continue posteriorly in the inter ventricular groove, or might bifurcate to be posterior descending artery (PDA) and posterior-lateral vessel (PLV).…”

Section: Introductionmentioning

confidence: 99%

“…And the p-value was far less than 0.05 indicating a significant correlation between female gender and multivessel CABG. As shown in table(3)…”

mentioning

confidence: 99%

Multivessel Coronary Artery Disease in Diabetes Mellitus Patients

Mohammed

2019

KJAR

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Coronary artery disease is the most common cardiac disease with a worldwide distribution, and it is responsible for most of the mortalities regarding cardiovascular diseases if not detected early and treated properly. There are many lines in the treatment of coronary artery disease, starting from medical therapy, percutaneous coronary intervention, and coronary artery bypass graft surgery, preference of the choice of the type of the treatment depends on many factors. In fact when coronary artery bypass graft is indicated, although it carries a considerable risk of surgery, but the long-term survival is notably better than the other ways of treatment. This study done to determine that the prevalence of multivessel coronary artery disease is more in diabetic patients than non-diabetic patients. And more in female than male. In this study hundred ninety patients were retrospectively studied, all of them underwent coronary artery bypass graft surgery with or without other concomitant cardiac procedure (like valve surgery), but most of them were coronary artery bypass graft alone. We found that the number of the coronary arteries affected is strongly related to the presence of the diabetes mellitus. And females are more prone to have coronary artery disease than male. Thus diabetes mellitus is the most common risk factor for the development of cardiovascular disease, and the severity of the condition is confirmed by the number of the coronary arteries involved as well as the calcification or multiple stenosis in the same vessel.

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Coronary Artery Disease and Diabetes Mellitus

Cited by 176 publications

References 114 publications

Risk factors of premature coronary artery disease in Iran: A systematic review and meta‐analysis

Risk factors of premature coronary artery disease in Iran: A systematic review and meta‐analysis

Circulating miR‐130 and its target PPAR‐γ may be potential biomarkers in patients of coronary artery disease with type 2 diabetes mellitus

Multivessel Coronary Artery Disease in Diabetes Mellitus Patients

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