Coronary artery disease and dyslipidemia within Europe: genetic variants in lipid transport gene loci in German subjects with premature coronary artery disease

Kay, A.; März, Winfried; Hoffmann, Michael M.; Zhang, Q.; Cavanna, J.; Baroni, Marco Giorgio; Shine, Brian; Galton, D. J.

doi:10.1016/s1567-5688(01)00003-4

Cited by 11 publications

(7 citation statements)

References 28 publications

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“…The homozygotes for the alleles T and Del had higher levels of these lipids than individuals heterozygous for both alleles, who had intermediate levels; this result is compatible with a co-dominant effect of these polymorphisms. These results are in agreement with published data showing that the Del and T alleles are associated with increased levels of TC and/or LDL-C in different populations with distinct diseases [9, 35–37]. However, Xu et al and Ye et al found no association of the polymorphism in the signal peptide of the gene with TC and LDL-C levels in the Finnish and Chinese populations, respectively [38, 39].…”

Section: Discussionsupporting

confidence: 92%

Genetic Markers Associated to Dyslipidemia in HIV‐Infected Individuals on HAART

Lazzaretti

Gasparotto

Sassi

et al. 2013

The Scientific World Journal

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This study evaluated the impact of 9 single nucleotide polymorphisms (SNPs) in 6 candidate genes (APOB, APOA5, APOE, APOC3, SCAP, and LDLR) over dyslipidemia in HIV-infected patients on stable antiretroviral therapy (ART) with undetectable viral loads. Blood samples were collected from 614 patients at reference services in the cities of Porto Alegre, Pelotas, and Rio Grande in Brazil. The SNPs were genotyped by conventional polymerase chain reaction (PCR) and real-time PCR. The prevalence of dyslipidemia was particularly high among the protease inhibitors-treated patients (79%). APOE (rs429358 and rs7412) genotypes and APOA5 −1131T>C (rs662799) were associated with plasma triglycerides (TG) and low-density-lipoprotein cholesterol levels (LDL-C). The APOA5 −1131T>C (rs662799) and SCAP 2386A>G (rs12487736) polymorphisms were significantly associated with high-density-lipoprotein cholesterol levels. The mean values of the total cholesterol and LDL-C levels were associated with both the APOB SP Ins/Del (rs17240441) and APOB XbaI (rs693) polymorphisms. In conclusion, our data support the importance of genetic factors in the determination of lipid levels in HIV-infected individuals. Due to the relatively high number of carriers of these risk variants, studies to verify treatment implications of genotyping before HAART initiation may be advisable to guide the selection of an appropriate antiretroviral therapy regimen.

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Section: Discussionsupporting

confidence: 92%

Genetic Markers Associated to Dyslipidemia in HIV‐Infected Individuals on HAART

Lazzaretti

Gasparotto

Sassi

et al. 2013

The Scientific World Journal

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“…Moreover, HDL cholesterol acts as a protective factor for stroke development, similar to previous reports 12 . We did not evaluated the LPL polymorphisms association with altered lipid profile since previous studies failed to do so or had led to inconsistent results 13 .…”

Section: Discussionsupporting

confidence: 59%

C0169: Polymorphisms of the Lipoprotein Lipase Gene as Genetic Markers for Stroke in Colombian Population

Pereira¹,

Vargas²

2014

Thrombosis Research

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“…Variants at six loci previously shown to be associated with CAD [17-19] were studied, and the 11 variants analysed were: apolipoprotein A1: Xmn 1 5' to the Apo A1 gene, Msp 1 in intron 3, Pst 1 3' of the gene; apolipoprotein B : Xba 1; apolipoprotein CIII: Sst 1 for C3175G, exon 4, apolipoprotein E : Hha 1 for e2, e3, e4 ; LIPC : Msp 1 for Thr202Thr (C to G); and lipoprotein lipase : Hind 111 in intron 8, Taq 1 forD9N (G to A), Rsa 1 for N291S (A to G), and Mnl 1 for S447X (C to G).…”

Section: Methodsmentioning

confidence: 99%

“…Five microliters of digestion mixture containing the manufacturer's recommended restriction buffer and 5 U of the above mentioned restriction enzymes were added to the amplification product and incubated as described [17-19]. …”

Section: Methodsmentioning

confidence: 99%

Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD

et al. 2003

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BackgroundCurrent evidence demonstrates that positive family history and several alterations in lipid metabolism are all important risk factors for coronary artery disease (CAD). All lipid abnormalities themselves have genetic determinants. Thus, objective of this study was to determine whether 6 genetic variants potentially related to altered lipid metabolism were associated with CAD and with lipid abnormalities in an Italian population. These genetic variables were: apolipoprotein E (Apo E), Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and the hepatic lipase (LIPC) genes. Furthermore, an 8 years prospective analysis of clinical cardiovascular events was related to the various genetic markers.Methods102 subjects with established coronary artery disease and 104 unrelated normal subjects were studied. CAD Patients were followed up for 8 years, and clinical CAD outcomes (a second coronary angioplasty (PTCA), myocardial infarction, coronary artery by-pass graft (CABG), cardiovascular deaths), available from 60 subjects, were related to the genetic variants by multiple regression analysis. Results. Of the six lipid loci studied (for a total of 11 polymorphisms) only the apolipoprotein E, Apo B and LIPC polymorphisms distinguished between case and controls. However, multivariate analysis accounting for clinical and metabolic predictors of CAD showed that only the ApoB Xba1 and ApoE4 polymorphism associated with CAD in this Italian population. When lipid parameters were related to genotypes, the ApoE, ApoB, and LIPC gene polymorphisms were associated to various markers of dyslipidaemia in the CAD patients, confirming previous reports. When the occurrence of a second cardiovascular event was related to genotypes, an independent role was observed for the LIPC gene T202T variant.Conclusionsvariation in LIPC (hepatic lipase) gene associates with clinical outcomes in Italian patients with established CAD. Further studies on the LIPC gene in CAD patients are warranted, in particular looking at the possible influences on clinical outcomes.

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Coronary artery disease and dyslipidemia within Europe: genetic variants in lipid transport gene loci in German subjects with premature coronary artery disease

Cited by 11 publications

References 28 publications

Genetic Markers Associated to Dyslipidemia in HIV‐Infected Individuals on HAART

Genetic Markers Associated to Dyslipidemia in HIV‐Infected Individuals on HAART

C0169: Polymorphisms of the Lipoprotein Lipase Gene as Genetic Markers for Stroke in Colombian Population

Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD

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