Coronary artery disease as the cause of incident heart failure in the population

Fox, Kevin; Cowie, Martin R.; Wood, D; Coats, Andrew J.S.; Gibbs, J. Simon R.; Underwood, S. Richard; Richard, Turner; Poole‐Wilson, P.A.; Davies, SW; Sutton, George C.

doi:10.1053/euhj.2000.2289

Cited by 332 publications

(209 citation statements)

References 23 publications

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“…Knowing that IHD can cause HF despite the lack of symptomatic ischemia this is more likely to be an underestimation than an overestimation of the prevalence of IHD in the HF population. The prevalence however is in concordance with the reported prevalence of IHD of 52% in patients with HF from an invasive study of coronary artery morphology [15]. For patients with a depressed LVEF without structural heart disease the prevalence of IHD determined invasively has been reported as high as 82% but this was in a population referred for cardiac catheterization [16].…”

Section: Discussionsupporting

confidence: 81%

Different prognostic impact of systolic function in patients with heart failure and/or acute myocardial infarction

Thune

Carlsen

Buch

et al. 2005

European J of Heart Fail

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Aims: To study the prognostic importance of left ventricular systolic function in patients with heart failure (HF) and acute myocardial infarction (AMI) with respect to the presence of prior heart failure and known ischemic heart disease. Methods: In 13,084 consecutive patients diagnosed with either AMI or HF, a medical history and an echocardiographic assessment of left ventricular systolic function by wall motion index (WMI) were obtained. Patients were divided into four groups: AMI with or without a history of HF, and primary HF (no recent AMI) with or without a history of ischemic heart disease (IHD). Mortality was assessed after nine years of follow-up. Results: WMI stratified patients according to all-cause mortality in all four groups of patients ( p b 0.0001). For a decrease in WMI of 0.3 (corresponding to a decrease in left ventricular ejection fraction of 0.1), the hazard ratio was 1.61 (95% CI:1.48-1.76) for AMI patients without prior HF, 1.43 (1.38-1.48) for AMI patients with prior HF, 1.26 (1.22-1.30) for primary HF patients with IHD and 1.23 (1.18-1.27) for HF patients without IHD. Conclusion: WMI stratifies patients with IHD and/or HF according to risk of all-cause death. The presence of HF attenuates the prognostic power of WMI.

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Section: Discussionsupporting

confidence: 81%

Different prognostic impact of systolic function in patients with heart failure and/or acute myocardial infarction

Thune

Carlsen

Buch

et al. 2005

European J of Heart Fail

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“…Ischemic left ventricular (LV) dysfunction is the most common etiology of heart failure in Western society 1 and continues to represent a high-risk subset of patients undergoing percutaneous coronary intervention (PCI). While the use of hydroxymethylglutaryl-coenzyme A reductase inhibitors, also called statins, has been shown to decrease the incidence of myocardial infarction (MI) and death in patients with coronary artery disease (CAD), [2][3][4] few data have been gathered regarding outcome in patients with LV dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Effect of statins and white blood cell count on mortality in patients with ischemic left ventricular dysfunction undergoing percutaneous coronary intervention

Lipinski

Martin

Cowley

et al. 2006

Clinical Cardiology

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SummaryBackground: While morbidity and mortality were shown to be increased in the setting of an elevated white blood cell (WBC) count for patients with acute coronary syndrome, the impact of statin therapy on mortality for patients with an elevated WBC count is unknown in high-risk patients with coronary artery disease.Hypothesis: The goal of this study was to determine whether statin therapy improved survival in patients with elevated WBC count undergoing percutaneous coronary intervention (PCI) with preexisting left ventricular (LV) dysfunction, a population at high risk for adverse outcomes.Methods: We retrospectively evaluated consecutive patient procedures performed at our institution from 1996 through 1999. Patients had a technically adequate angiographic left ventriculogram with a calculated ejection fraction (EF) ≤ 50%. Patients with prior coronary artery bypass graft were excluded. Mortality data were retrieved using the U.S. Social Security Death Index. Follow-up ranged from 3.5 to 6.5 years. Means are provided with ± standard deviation, and p values < 0.05 were considered significant.

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“…Predictors of heart failure in patient medical history, ECG and echocardiography were used in order to identify referred patients in whom a firm diagnosis of LHF could be made noninvasively [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Noninvasive identification of left-sided heart failure in a population suspected of pulmonary arterial hypertension

et al. 2015

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Exclusion of pulmonary hypertension secondary to left-sided heart disease (left heart failure (LHF)) is pivotal in the diagnosis of pulmonary arterial hypertension (PAH). In case of doubt, invasive measurements are recommended. The aim of the present study was to investigate whether it is possible to diagnose LHF using noninvasive parameters in a population suspected of PAH. 300 PAH and 80 LHF patients attended our pulmonary hypertension clinic before August 2010, and were used to build the predictive model. 79 PAH and 55 LHF patients attended our clinic from August 2010, and were used for prospective validation.A medical history of left heart disease, S deflection in V1 plus R deflection in V6 in millimetres on ECG, and left atrial dilation or left valvular heart disease that is worse than mild on echocardiography were independent predictors of LHF. The derived risk score system showed good predictive characteristics: R 2 =0.66 and area under the curve 0.93. In patients with a risk score ⩾72, there is 100% certainty that the cause of pulmonary hypertension is LHF. Using this risk score system, the number of right heart catheterisations in LHF may be reduced by 20%.In a population referred under suspicion of PAH, a predictive model incorporating medical history, ECG and echocardiography data can diagnose LHF noninvasively in a substantial percentage of cases. @ERSpublications A risk score system can identify left-heart failure as alternative PH cause in patients suspected of PAH clinically http://ow.ly/JAIkR

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Coronary artery disease as the cause of incident heart failure in the population

Cited by 332 publications

References 23 publications

Different prognostic impact of systolic function in patients with heart failure and/or acute myocardial infarction

Different prognostic impact of systolic function in patients with heart failure and/or acute myocardial infarction

Effect of statins and white blood cell count on mortality in patients with ischemic left ventricular dysfunction undergoing percutaneous coronary intervention

Noninvasive identification of left-sided heart failure in a population suspected of pulmonary arterial hypertension

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