Coronary Artery Disease Assessed by Computed Tomography in Patients with Psoriasis: A Systematic Review and Meta-Analysis

Kaiser, Hannah; Abdulla, Jawdat; Henningsen, Knud W.; Skov, Lone; Hansen, Peter Riis

doi:10.1159/000502138

Cited by 27 publications

(18 citation statements)

References 41 publications

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“…However, a coronary calcium score > 400 was more frequently observed in patients with severe psoriasis, even adjusting for the risk estimated by the Framingham score [ 74 ]. Recently, a systematic review and meta-analysis showed that the patients with psoriasis had an increased risk of coronary calcium score > 0 (RR 1.14, 95% CI 1.04–1.26; p = 0.004) and > 100 (RR 1.71, 95% CI 1.28–2.30; p < 0.001) compared with controls [ 75 ].…”

Section: Stratification Of Cardiovascular Riskmentioning

confidence: 99%

Psoriasis and Cardiovascular Risk: A Comprehensive Review

Masson

Lobo²,

Molinero³

2020

Adv Ther

129

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Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. Individuals with psoriasis have an increased risk of developing other chronic health diseases such cardiovascular disorders. The high incidence of cardiovascular events in the population with psoriasis could be explained by several mechanisms. The high prevalence of traditional cardiovascular risk factors and metabolic abnormalities contributes to the high cardiovascular burden in patients with psoriasis. Likewise, the presence of systemic inflammation in combination with metabolic abnormalities may act in a synergistic manner to increase cardiovascular risk in these patients. This review focused on epidemiologic and clinical evidence linking psoriasis to cardiovascular risk factors and cardiovascular disease. We described the possible pathophysiological mechanisms that justify this association and analyzed the best way to stratify the cardiovascular risk in patients with psoriasis. We also described the usefulness of the therapies frequently used in cardiovascular prevention and analyzed the impact of the specific psoriasis medication on cardiovascular risk factors or major atherosclerotic events. Knowledge of the application of different cardiovascular prevention strategies could mean an advantage in performing the difficult task of estimating cardiovascular risk and treating cardiovascular risk factors in this particular group of patients.

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Section: Stratification Of Cardiovascular Riskmentioning

confidence: 99%

Psoriasis and Cardiovascular Risk: A Comprehensive Review

Masson

Lobo²,

Molinero³

2020

Adv Ther

129

View full text Add to dashboard Cite

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“…Coronary computed tomography angiography (CCTA) is a non-invasive technique that gives direct anatomic visualization of the coronary artery wall, reliably measures the overall plaque burden, size and severity of luminal restriction [24], and identifies vulnerable, lipid-rich plaques with a high likelihood of rupture leading to an acute coronary syndrome [25]. Despite that patients with PsD have an increased risk of CAD compared with controls [17,26], there are limited data available on CAD as assessed by CCTA in this population. Hjuler and colleagues compared prevalence, severity, and subtypes of coronary plaques between patients with severe psoriasis, atopic dermatitis (AD), and asymptomatic controls without known CVD.…”

Section: Coronary Ct Scansmentioning

confidence: 99%

Cardiovascular Comorbidities in Psoriatic Disease

Simonyi

Haroon²,

FitzGerald

2019

Rheumatol Ther

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Psoriatic disease (PsD) is a multisystem inflammatory disorder with a high prevalence of cardiovascular (CV) risk factors contributing to accelerated atherosclerosis and its sequelae. Imaging studies, notably with ultrasound, computed tomography, and positron emission tomography (PET) scanning have confirmed significant atherosclerotic change with plaque formation and vessel stenosis. Atherosclerosis is likely driven by a combination of traditional risk factors which occur more frequently in PsD and by systemic inflammation with associated pro-inflammatory cytokine production. While the mechanisms driving atherosclerosis in PsD are incompletely understood, it is now best practice to try to minimize the impact of CV risk factors by regular assessment, prevention, and treatment and also by ensuring that inflammatory musculoskeletal and cutaneous disease is adequately suppressed. Future studies need to focus on improving our understanding of the mechanisms driving atherosclerosis and, as a consequence, developing more rationale approaches to prevention and treatment.

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“…In a systematic review and meta-analysis, Kaiser et al , based on the analysis and summary of results of 14 studies involving cardiac computed tomography, showed that patients with psoriasis more often suffered from coronary artery disease, with higher CS values and a greater number of unstable atherosclerotic plaques than the healthy population [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Atherosclerosis attacks in patients with psoriasis vulgaris but without a relationship with the severity and course of the disease

Białecka

Białecki

Serafin

et al. 2021

pdia

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Introduction In recent years numerous research studies have indicated that chronic inflammation in psoriasis can be associated with an increased risk of developing atherosclerosis. Aim The presented study was aimed at demonstrating whether patients suffering from psoriasis vulgaris are at a greater risk of developing atherosclerosis depending on the presence of selected cardiovascular risk factors and the course and severity of the disease. Material and methods Sixty-two patients with diagnosed psoriasis vulgaris and 42 healthy volunteers were included in the study. All the patients underwent carotid ultrasound with the assessment of the common carotid artery intima-media thickness (IMT) and the computed tomography with determination of coronary artery calcification (CAC). Results The IMT was significantly higher in the study group (1.030 ±0.303 mm vs. 0.838 ±0.151 mm, p < 0.0001). We also found a significantly increased severity of Calcium Score (CS) in Agatston units (168.20 ±309.63 vs. 24.52 ±43.21, p = 0.0207) of CAC in patients with psoriasis. There was no significant correlation between the degree of atherosclerosis and psoriasis severity determined in the PASI (Psoriasis Area and Severity Index) scale, duration of the disease, number of exacerbations per year or C-reactive protein values. Conclusions The study showed an increased risk of developing atherosclerosis in patients diagnosed with psoriasis vulgaris, but no correlation was found between the degree of atherosclerosis and the severity of the disease.

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Coronary Artery Disease Assessed by Computed Tomography in Patients with Psoriasis: A Systematic Review and Meta-Analysis

Cited by 27 publications

References 41 publications

Psoriasis and Cardiovascular Risk: A Comprehensive Review

Psoriasis and Cardiovascular Risk: A Comprehensive Review

Cardiovascular Comorbidities in Psoriatic Disease

Atherosclerosis attacks in patients with psoriasis vulgaris but without a relationship with the severity and course of the disease

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