Coronary Artery Disease in Systemic Lupus Erythematosus: What Do the Facts Say?

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect any organ with a predisposition for women of reproductive age. It is related to a higher risk of cardiovascular events, increasing it up to 50 times in young people, and 30% of deaths are attributed to coronary artery disease. The risk of developing cardiovascular disease in SLE is related not only to traditional cardiovascular risks factors such as advanced age, hypertension, dyslipidemia, and diabetes but also to disease-specific factors, such as degree of activity, autoantibodies, organ damage, and treatment. Accelerated atherosclerosis is one of the main contributors to pathogenesis. Manifestations range from angina to acute myocardial infarction and sudden death. Markers have been studied for the detection of subclinical disease and stratification of these patients, as well as different treatment options to improve the cardiovascular prognosis of the disease.

Response of Lipid Profile to Laser Acupuncture along with Diet and Pilates Exercise in Obese Women with Systemic Lupus Erythematosus: a Randomized Controlled Trial

“…Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease that has a higher prevalence in women than men. Compared with age-matched healthy peers, obese women with SLE have a 50-fold higher incidence of coronary artery disease (CAD) [1].…”

“…This condition can be triggered by concurrent systemic diseases, such as diabetes mellitus or thyroid gland disorders, substantial metabolic shifts related to menopause and aging, chronic use of steroidal agents, and the number of organs affected by SLE. Optimal lifestyle interventions for dyslipidemia and obesity in SLE patients involve dietary modifications and exercise therapy [1].…”