Coronary Artery Disease in Women: A Comprehensive Appraisal

Pravda, Nili Schamroth; Karny-Rahkovich, Orith; Shiyovich, Arthur; Pravda, Miri Schamroth; Rapeport, Naomi; Vaknin‐Assa, Hana; Eisen, Alon; Kornowski, Ran; Porter, Avital

doi:10.3390/jcm10204664

Cited by 11 publications

(13 citation statements)

References 85 publications

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“…Besides, there was a higher percentage of females than males on diuretics and nitrates, which can be explained by higher prevalence of heart failure among the former. Unstable angina pectoris was the most common diagnosis among our study population, in line with China Heart Survey [ 27 ], There was a predominance in female patients and myocardial infarction presented more commonly in males [ 38 ]. Moreover, hypertension and heart failure were more prevalent in females, which may further contribute to increase relative risk of mortality in diabetic females when compared to males with CAD.…”

Section: Discussionsupporting

confidence: 54%

Abnormal glucose regulation in Chinese patients with coronary artery disease: a gender analysis

Liu

Zhu

et al. 2022

J Cardiothorac Surg

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Background Diabetes and impaired glucose regulation are very common in patients with coronary artery disease (CAD). In this study, we aim to investigate the prevalence of abnormal glucose regulation in men and women in Chinese CAD patients. Methods In this retrospective study, 4100 patients (male, n = 2873; female, n = 1227)with CAD were enrolled. The mean age of these patients was 63 years. The demographic data, medical history, echocardiography findings and blood investigations were collected and analyzed. Results In this population, 953 (24%) patients had definite diagnosis of type 2 diabetes mellitus, including 636 males (23%) and 317 females (27%). There was a higher prevalence of diabetes in females than men (p < 0.05). For the remaining patients, 48% (n = 959) undergone an oral glucose tolerance test (OGTT), which revealed that 83 male patients (12%) and 41 female patients (16%) suffered from the type 2 diabetes (p > 0.05). 283 men (40%) and 105 women (41%) had impaired glucose regulation (IGR) (p > 0.05). Only 338 men (25%) and 109 women (19%) showed the normal glucose regulation, implying a higher prevalence of abnormal glucose regulation in females (p < 0.01). The odd ratio (OR) showed that women were more prone to have diabetes mellitus or IGT than men and the OR was 1.44 and 1.43 respectively. Conclusion Abnormal glucose regulation is highly prevalent in CAD patients. The women are more prone to have diabetes mellitus or IGT than men.

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Section: Discussionsupporting

confidence: 54%

Abnormal glucose regulation in Chinese patients with coronary artery disease: a gender analysis

Liu

Zhu

et al. 2022

J Cardiothorac Surg

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“…Compared with men, women with NSTE-ACS typically have an older age, have multiple cardiovascular risk factors, and are under treatment. They also have higher rates of myocardial ischemia and significantly higher all-cause mortality [ 32 ]. On the other hand, medically managed ACS patients with worse chronic kidney disease (CKD) show markedly increased long-term risks of ischemic and bleeding complications [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

The association between tissue doppler-derived E/(e′s′) ratio and coronary atherosclerosis severity measured by the SYNTAX score in patients with non-ST elevation-acute coronary syndrome

Nabati

Golshani

Taghavi

et al. 2023

BMC Cardiovasc Disord

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Background The prognosis of patients hospitalized with non-ST elevation-acute coronary syndrome (NSTE-ACS) is typically determined by the existence and severity of myocardial necrosis and left ventricular (LV) remodeling. Aim The present study was to assess the association between the E/(e′s′) ratio and the coronary atherosclerosis severity, measured by the SYNTAX score, in patients with NSTE-ACS. Methods Utilizing a descriptive correlational research design, this study was prospectively conducted on 252 patients with NSTE-ACS, undergoing an echocardiography to determine the left ventricular ejection fraction (LVEF), the left atrial (LA) volume, the pulsed-wave (PW) Doppler-derived transmitral early (E) and late (A) diastolic velocities, and the tissue Doppler (TD)-derived mitral annular early diastolic (e′) and peak systolic (s′) velocities. After that, a coronary angiography (CAG) was performed, and the SYNTAX score was calculated. Results The patients were divided into two groups, viz., those with the E/(e′s′) ratio < 1.63 and the cases with the ratio ≥ 1.63. The results revealed that the patients with a high ratio were older, had a higher prevalence of females, a SYNTAX score ≥ 22, and a lower glomerular filtration rate than those with a low ratio (p-value < 0.001). Besides, these patients had larger indexed LA volume and lower LVEF than others (p-value: 0.028 and 0.023, respectively). Furthermore, the multiple linear regression outcomes established a positive independent association between the E/(e′s′) ratio ≥ 1.63 (B = 5.609, 95% CI 2.324–8.894, p-value = 0.001) and the SYNTAX score. Conclusion The study results demonstrated that the patients hospitalized with NSTE-ACS and the E/(e′s′) ratio ≥ 1.63 had worse demographic, echocardiographic, and laboratory profiles and a higher prevalence of a SYNTAX score ≥ 22 than those with a lower ratio.

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“…They also have higher rates of myocardial ischemia and a signi cantly higher all-cause mortality than men. (24). On the other hand, medically managed ACS patients with worse chronic kidney disease shows markedly increased long-term risks of ischemic and bleeding complications (25).…”

Section: Discussionmentioning

confidence: 99%

Association between tissue-Doppler derived E/ (e's') ratio and coronary atherosclerosis severity measured by the SYNTAX score in patients with non- ST elevation-acute coronary syndrome

Nabati

Golshani

Taghavi

et al. 2022

Preprint

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Background The prognosis of patients with NSTE-ACS is determined by the existence and severity of myocardial necrosis and left ventricular (LV) remodeling. Aim The aim of our study was to assess the association between E/ (e's') ratio and coronary atherosclerosis severity measured by the SYNTAX score in patients with NSTE-ACS. Methods This study was a descriptive analytical study on 252 patients with NSTE-ACS. All patients underwent echocardiography and left ventricular ejection fraction (LVEF), left atrial (LA) volume, pulsed-Doppler derived transmitral early (E wave) and late (A wave) diastolic velocities, and tissue-Doppler derived mitral annular early diastolic (e') and peak systolic (s') velocities were determined. Coronary angiography was then performed and SYNTAX score was calculated. Results Patients were divided into two groups based on patients with an E/ (e's') < 1.63 and those with an E/ (e's') ≥ 1.63. Patients with a high ratio were older and had higher prevalence of female sex, a SYNTAX score ≥ 22, and lower glomerular filtration rate than those with a low ratio (P value: <0.001). Also, these patients had larger indexed LA volume and lower LVEF than other ones (P value: 0.028 and 0.023, respectively). Furthermore, multiple linear regression analysis showed E/ (e's') ≥ 1.63 (B = 5.609, 95% CI: 2.324–8.894, P Value = 0.001) had a positive independent association with SYNTAX score. Conclusions The results of our study showed hospitalized patients with NSTE-ACS and an E/ (e’s’) ratio ≥ 1.63 had worse clinical and laboratory profile, and more complex coronary artery lesions than those with a lower ratio.

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Coronary Artery Disease in Women: A Comprehensive Appraisal

Cited by 11 publications

References 85 publications

Abnormal glucose regulation in Chinese patients with coronary artery disease: a gender analysis

Abnormal glucose regulation in Chinese patients with coronary artery disease: a gender analysis

The association between tissue doppler-derived E/(e′s′) ratio and coronary atherosclerosis severity measured by the SYNTAX score in patients with non-ST elevation-acute coronary syndrome

Association between tissue-Doppler derived E/ (e's') ratio and coronary atherosclerosis severity measured by the SYNTAX score in patients with non- ST elevation-acute coronary syndrome

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