Coronary artery dominance dependent collateral development in the human heart

Ajayi, N. O.; Vanker, E. A.; Satyapal, K. S.

doi:10.5603/fm.a2016.0051

Cited by 10 publications

(9 citation statements)

References 24 publications

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“…A previous study showed that although RCA dominance is common in the population, there may not be any association between LCA dominance and heart disease. In another study, it was found that in patients with acute coronary syndrome, left dominance was an independent predictor of enhanced long-term mortality 24,25 .…”

Section: Discussionmentioning

confidence: 97%

Anatomical indicators of the heart and coronary arteries: An anthropometric study

Darvishi

Moayeri

2020

Biomed. Res. Ther.

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Introduction: Previous studies confirm that there is no anthropometric index of normal Iranian hearts, including diameter of cardiac valve, thickness of myocardial septum and coronary artery variation. The purpose of this study was to assess the anatomical indexes of the human heart and coronary artery in the Iranian population. Methods: The study was performed with 207 adult human hearts in both sexes (182 male and 25 female), fixed in 10% formaldehyde. Myocardial thickness and diameter of heart valves were measured using a Vernier caliper. Assessments of the coronary artery were carried out after removal of the pericardium. Results: Analysis of 207 cadaver coronary arteries showed left coronary artery (LCA) dominance type was present in 6.3% of corpus, and balance was present in 4.3% of corpus, while the largest number (89.4%) had right coronary artery (RCA) dominance. The mean values of the morphometric data are as follows: right atrial wall thickness (2.08 +/- 0.04 mm), left atrial wall thickness (2.08 +/- 0.04 mm), interatrial wall thickness (4.92 +/- 0.08 mm), right ventricular wall thickness (3.35 +/- 0.05 mm), left ventricular wall thickness (8.36 +/- 0.13 mm), interventricular wall thickness (12.01 +/- 0.2 mm), diameter of the aorta (23.6 +/- 0.4 mm), diameter of the pulmonary artery (24.94 +/- 0.4 mm), large diameter of the mitral valve (34.16 +/- 0.27 mm), and large diameter of the tricuspid valve (38.8 +/- 0.24 mm). Conclusion: The anatomical knowledge of cardiac indicators and coronary artery data will be helpful and clinically relevant, especially for cardiac surgeons for coronary artery bypass grafting and coronary arteriography.

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Section: Discussionmentioning

confidence: 97%

Anatomical indicators of the heart and coronary arteries: An anthropometric study

Darvishi

Moayeri

2020

Biomed. Res. Ther.

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“…Although there was no significant difference between the two groups in terms of early results in our dataset, there was a strong association between MACCE and LD in the long term. Development of functional coronary collaterals has been shown to be smaller in LD patients than in RD patients [12] . This morphological pattern may cause the LD patients to be more vulnerable to ongoing atherosclerotic process after CABG.…”

Section: Discussionmentioning

confidence: 98%

Prognostic Value of Coronary Dominance in Patients Undergoing Elective Coronary Artery Bypass Surgery

Selçuk

Çevirme

Bugra

2020

Braz J Cardiovasc Surg

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Objective: To evaluate the clinical impact of coronary dominance type in terms of early and long-term outcomes in patients undergoing elective coronary artery bypass grafting (CABG).Methods: A total of 844 consecutive patients who underwent elective CABG were divided into two groups based on preoperative angiographic views as left dominant (LD) and right dominant or codominant (RD+CD). The measured outcomes were postoperative complications, 30-day mortality, long-term mortality, and major adverse cardiac and cerebrovascular events (MACCE).Results: RD+CD was present in 87.9% (n=742) and LD in 12.1% (n=102) of patients. Postoperative complications, 30-day mortality, and 30-day readmissions were similar in both groups. The median duration of follow-up was 3.4 years. LD was not an independent predictor of mortality (adjusted hazard ratio [HR]1.53, 95% confidence interval [CI] 0.89-2.45, P=0.12), but it was an independent predictor of MACCE in the long term (adjusted HR 2.18, 95% CI 1.39-3.42, P=0.001).Conclusion: In patients undergoing elective surgical revascularization, left coronary dominance is associated with increased MACCE risk in the long term. Therefore, the assessment of coronary dominance type should be an integral part of outpatient management after CABG.

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“…Concerning the influence of age and sex, previous studies show that collaterals are higher in patients ≥60 years of age and in males with obstructive coronary artery disease in the coronary arteries (Kinnaid et al, 2008). Zhen et al found that the collateral formation is less in females and reduces with increasing age (Ajayi et al, 2017). But in the above study, no significant association was found between age and gender on the collateral score with serum VEGF‐A level.…”

Section: Discussionmentioning

confidence: 99%

Correlation of serum vascular endothelial growth factor and cardiovascular risk factors on collateral formation in patients with acute coronary artery syndrome

Balakrishnan

Kumar

2022

Clinical Anatomy

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Coronary collaterals serve as an alternative source of blood flow in obstructive coronary heart disease. Coronary collateral development is induced by various angiogenic growth factors, including vascular endothelial growth factor-A (VEGF-A). Cardiovascular risk factors strongly associated with coronary artery disease include age, sex, elevated serum cholesterol, disturbed carbohydrate metabolism, and elevated blood pressure. A better understanding of the effects of these cardiovascular risk factors and serum VEGF-A level on collateral recruitment is necessary for a better prognosis in coronary artery diseases and new insight for further therapeutic promotion of coronary collaterals.220 consecutive patients undergoing coronary angiography with a mean age of 61 ± 9.83 were selected for the analysis. Two milliliters of blood were taken from the patients for analysis. The blood serum VEGF concentration was quantified via the ELISA method. Angiograms and other clinical reports were collected.Significant coronary artery disease was diagnosed in those with ≥ 70% of stenosis in at least one of the coronary arteries. The angiographic and clinical data were documented. The collateral grading was done according to the Rentrop Scoring system.The serum vascular endothelial growth factor level was correlated with the collateral score and cardiovascular risk factors like age, sex, type II diabetes, blood pressure, and cholesterol level. An increase in the level of the collateral score was noted with an increase in the level of VEGF in blood serum. A significant association was founded between serum VEGF level and cardiovascular risk factors on collateral formation in patients with diabetes and hypertension.

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Coronary artery dominance dependent collateral development in the human heart

Abstract: (Folia Morphol 2017; 76, 2: 191-196)

Cited by 10 publications

References 24 publications

Anatomical indicators of the heart and coronary arteries: An anthropometric study

Anatomical indicators of the heart and coronary arteries: An anthropometric study

Prognostic Value of Coronary Dominance in Patients Undergoing Elective Coronary Artery Bypass Surgery

Correlation of serum vascular endothelial growth factor and cardiovascular risk factors on collateral formation in patients with acute coronary artery syndrome

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