Coronary artery endothelial dysfunction after global ischemia, blood cardioplegia, and reperfusion

Nakanishi, Koji; Zhao, Zhi‐Qing; Vinten‐Johansen, Jakob; Lewis, Jon C.; McGee, D.Scott; Hammon, John W.

doi:10.1016/0003-4975(94)91099-5

Cited by 56 publications

(23 citation statements)

References 23 publications

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“…This dysfunction preferentially involves pertussis toxin sensitive G-proteins mediated relaxations (Gi-protein) [4]. During CPB, sanguinous cardioplegia generally provides better endothelial and myocardial protection than crystalloid cardioplegic solutions [6,7]. No study has shown an endothelial dysfunction of coronary arteries following CPB alone, without prolonged aortic cross-clamping [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Effect of tetrahydrobiopterin on selective endothelial dysfunction of epicardial porcine coronary arteries induced by cardiopulmonary bypass

Stevens

Fortier

Aubin

et al. 2006

European Journal of Cardio-Thoracic Surgery

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Section: Introductionmentioning

confidence: 99%

“…Regional and global ischemia-reperfusion of the coronary circulation during CPB with aortic cross-clamping is associated with an impairment of EDRF release [4][5][6]. This dysfunction preferentially involves pertussis toxin sensitive G-proteins mediated relaxations (Gi-protein) [4].…”

Section: Introductionmentioning

confidence: 99%

Effect of tetrahydrobiopterin on selective endothelial dysfunction of epicardial porcine coronary arteries induced by cardiopulmonary bypass

Stevens

Fortier

Aubin

et al. 2006

European Journal of Cardio-Thoracic Surgery

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“…Tal lesão produz dano de intensidade variável ao endotélio coronariano sendo a reperfusão o principal agente agressor (2,(10)(11)(12)(13) . Este tipo de lesão acarreta disfunção endotelial e afeta drasticamente a liberação basal e estimulada de NO, resultando em mudanças que propiciam aderência leucocitária, migração celular transendotelial, coagulação e aumento do tono vascular.…”

Section: Comentáriosunclassified

“…A comparação entre os grupos nesta fase não evidenciou diferença entre eles. A igualdade entre os grupos controle, extracorpórea sem pinçamento aórtico e isquemia, ratificaram estudos que revelam discreto dano endotelial associado à isquemia como fenômeno isolado (2,(10)(11)(12) . No grupo submetido à isquemia seguida de reperfusão constatou-se padrão de curvas semelhante aos demais, exibindo expressivo relaxamento.…”

Section: Estudo Da Fase Dependente De Receptor De Membranaunclassified

“…A comparação entre os grupos nesta fase não evidenciou diferença entre eles. A igualdade entre os grupos exibindo comportamento semelhante ao controle ratificou uma vez mais discreto dano endotelial associado à isquemia como fenômeno isolado (2,(10)(11)(12)(13) . Além disso, chamou a atenção, principalmente, sobre a possibilidade de concentrações fisiológicas de magnésio, como as contidas na solução de Krebs do perfusato, atenuarem os efeitos deletérios da reperfusão.…”

Section: Estudo Da Fase Dependente De Receptor De Membranaunclassified

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Disfunção endotelial após isquemia global e reperfusão em cirurgia cardíaca com circulação extracorpórea: estudo do papel do magnésio em artérias coronarianas caninas

Volpe

Carneiro

Magna³

et al. 2002

Rev Bras Cir Cardiovasc

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Introduction: Hypomagnesemia and ischemia followed by reperfusion often occur in cardiac surgery. Both of them are associated with endothelial dysfunction which interfers VOLPE, MA ET AL -Disfunção Endotelial após Isquemia Global e Reperfusão em Cirurgia Cardíaca com Circulação Extracorpórea: Estudo do Papel do Magnésio em Artérias Coronarianas Caninas Atualização e análise crítica. Cardiovasc 2002; 17(3): 187-200 Objective: The present study focuses on the endothelial dysfunction consequent to the lesion resulting from global ischemia followed by reperfusion and the potential protective influence of magnesium on the endothelium functional integrity in isolated coronaries of dogs. Rev Bras CirMethod: Segments of canine coronary arteries were suspended in organ chambers to measure isometric force. Endothelial dysfunction was evaluated by the ability of these segments to produce nitric oxide changing the initial isometric force. Four groups with six dogs in each one were selected: SEM CEC (control), CEC (110 minutes of perfusion without ischemia), ISQ (45 minutes of ischemia), ISQ/REP (45 minutes of ischemia followed by 60 minutes of reperfusion). The magnesium action was evaluated in three different phases: I (organ chambers with magnesium), II (organ chambers without magnesium) and III (organ chambers with restored magnesium). Three pharmacological agonists were used which represented the main steps involved in the nitric oxide production: the membrane receptor of the endothelial cell -acetylcholine (ACh); transduction of the signal between the receptor and the intracellular processes through the G-protein -sodium fluoride (NaF); liberation of intracellular stocks of calcium -calcium ionophore (A 23187 ). The study of endothelial function was combined with the evaluation of smooth muscle activity dependent on GMPcsodium nitroprusside (NPS).Results: The major findings of this investigation were as follows: 1) presence of magnesium in priming seemed to attenuate the endothelial dysfunction caused by global ischemia followed by reperfusion; 2) presence of magnesium in the organ chamber (phase I) was associated with the greatest relaxation in response to agonists of the nitric oxide production; 3) removal of magnesium in the organ chamber (phase II) was linked to the reduction in the relaxation intensity in response to agonists of the nitric oxide production; 4) the magnesium restoration to the organ chamber (phase III) allowed restoration of the relaxation observed in the phase I, only in response to the direct stimulation of the G-proteins. For the rest of the remaining agonists, the restoration was associated with the additional reduction in the relaxation intensity; 5) the smooth muscle received the influence of the magnesium concentration in the organ chamber.Conclusion: It was concluded that magnesium favorably influences the nitric oxide production by the coronary endothelium attenuating the endothelial dysfunction caused by global ischemia followed by reperfusion.Descriptors: Magnesium. Endotheli...

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Myocardial Protection From Reperfusion Injury With Adenosine

Vinten‐Johansen¹,

Zhao²

1997

Developments in Cardiovascular Medicine

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Coronary artery endothelial dysfunction after global ischemia, blood cardioplegia, and reperfusion

Cited by 56 publications

References 23 publications

Effect of tetrahydrobiopterin on selective endothelial dysfunction of epicardial porcine coronary arteries induced by cardiopulmonary bypass

Effect of tetrahydrobiopterin on selective endothelial dysfunction of epicardial porcine coronary arteries induced by cardiopulmonary bypass

Disfunção endotelial após isquemia global e reperfusão em cirurgia cardíaca com circulação extracorpórea: estudo do papel do magnésio em artérias coronarianas caninas

Myocardial Protection From Reperfusion Injury With Adenosine

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