Coronary artery endothelial dysfunction is positively correlated with low density lipoprotein and inversely correlated with high density lipoprotein subclass particles measured by nuclear magnetic resonance spectroscopy

Ford, Monique A.; McConnell, Joseph P.; Lavi, Shahar; Rihal, Charanjit S.; Prasad, Abhiram; Sandhu, Gurpreet S.; Hartman, Stacy; Lerman, Lilach O.; Lerman, Amir

doi:10.1016/j.atherosclerosis.2009.04.039

Cited by 30 publications

(32 citation statements)

References 33 publications

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“…Therefore, as pertains to endothelial eicosanoids production, HDL 2 appears to be more vasculoprotective than HDL 3 . In agreement with the in vitro data, it has been recently reported that large HDL particles, as assessed by NMR, are inversely associated with coronary endothelial dysfunction [72]. Consistent with this finding, a short-term treatment with niacin or with the CETP inhibitor JTT-705/dalcetrapib, both increasing plasma levels of large HDL particles [73,74], caused a significant increase of NO-mediated peripheral vasodilation in patients with low HDL-C [55,75,76].…”

Section: Hdl Quality Affects Hdl Functionsupporting

confidence: 72%

High-Density Lipoprotein Quantity or Quality for Cardiovascular Prevention?

Calabresi

Gomaraschi²,

Franceschini³

2010

CPD

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Plasma concentrations of HDL cholesterol (HDL-C) are strongly and inversely associated with cardiovascular risk, leading to the concept that therapies to enhance plasma HDL-C levels would be anti-atherogenic and protective against cardiovascular events. However, HDL are highly heterogeneous, with subclasses that can be separated and identified according to density, size, charge, and protein composition. There is evidence that these subclasses may differ in their functional anti-atherogenic properties. As a snapshot of the steady-state cholesterol carried by all HDL subclasses together, the individual HDL-C measurement is insufficient to capture the structural and functional variation in HDL particles. This review addresses the current knowledge on the structural and functional heterogeneity of HDL particles, and their relationship to cardiovascular disease, in the attempt of answering the question on whether certain subclasses of HDL may be better predictors of cardiovascular risk than HDL-C, and may be better targets than HDL-C for further improving cardiovascular disease reduction in the statin era.

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Section: Hdl Quality Affects Hdl Functionsupporting

confidence: 72%

High-Density Lipoprotein Quantity or Quality for Cardiovascular Prevention?

Calabresi

Gomaraschi²,

Franceschini³

2010

CPD

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“…Low HDL is an independent predictor of the risk of cardiovascular diseases (Miller et al 1977;Abbott et al 1988), and HDL levels are positively associated with endothelium-dependent vasodilatation in several studies (Bosevski et al 2007;Ford et al 2009;Tsuchiya et al 2009;Higashi et al 2010). In addition to the role of HDL in the uptake of peripheral cholesterol, HDL also exerts direct vasoprotective actions.…”

Section: Discussionmentioning

confidence: 96%

Weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice

Sallam

Fisher

Golbidi

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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The key roles that obesity, hyperglycemia, hyperlipidemia, inflammation, and oxidative stress play in the progression of diabetes vascular complications are well recognized; however, the relative contribution and importance of these individual factors remain uncertain. At 6, 10, or 14 weeks old, blood samples and thoracic aortae were collected from db/db mice and their non-diabetic controls. Plasma samples were analyzed for glucose, 8-isoprostane, CRP, triglycerides, LDL, and HDL as markers of glycemic status, oxidative stress, inflammation, and dyslipidemia, respectively. The responses of the aortic rings to high KCl, phenylephrine (PE), acetylcholine (ACh), and sodium nitroprusside were examined. Statistical methods were used to estimate the strength of the association between plasma variables and vascular functions. Systemic inflammation occurred in db/db mice at an earlier age than did hyperglycemia or oxidative stress. Aortae of db/db showed augmented contractions to PE which were positively correlated with weight, plasma glucose, 8-isoprostane, and CRP. Also, db/db mice showed impaired endothelium-dependent ACh vasorelaxation which was negatively correlated with weight, plasma glucose, and 8-isoprostane. Multivariate analysis and stepwise modeling show that CRP is the major determinant of the contractile responses, while weight and HDL are the major determinants of ACh-induced relaxation. Among the traditional risk factors of obesity, hyperglycemia, oxidative stress, inflammation, and dyslipidemia, our study reveals that weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice. Our findings partially resolve the complexity of diabetes vasculopathies and suggest targeting weight loss and inflammation for effective therapeutic approaches.

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“…This association is of concern because greater levels of large HDL particles are associated with a reduced risk of CVD and of insulin resistance, 23 and lower levels of large HDL are associated with greater coronary artery endothelial dysfunction. 24 Moreover, baseline large HDL was the lipoprotein subclass most associated with decreased risk of incident coronary heart disease events in HIV-infected subjects in the SMART study. 25 Together, this raises the possibility that persistent microbial translocation during prolonged ART may contribute to the increased CVD risk seen during chronic treatment of HIV in part due to adverse effects on HDL particles.…”

Section: Discussionmentioning

confidence: 99%

Microbial Translocation and Metabolic and Body Composition Measures in Treated and Untreated HIV Infection

Timmons

Shen

Aldrovandi

et al. 2014

AIDS Research and Human Retroviruses

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Circulating levels of microbial products such as lipopolysaccharide (LPS) are increased in HIV infection. Microbial translocation promotes obesity, insulin resistance, and dyslipidemia in other settings. We examined data from 178 subjects: an Indiana University (IU) cross-sectional study [N = 49 on antiretroviral therapy (ART), N = 47 not on ART], and a 24 week prospective study of ART initiation ACTG 5152s (N = 82). Pearson correlations were used to describe relationships of plasma LPS levels and soluble CD14 (sCD14), a marker of monocyte activation, with metabolic and body composition measures. HOMA-IR (a measure of insulin resistance) and LPS were correlated for the combined cohorts (r = 0.19, p = 0.02), particularly in the 5152s ART-naive cohort (r = 0.41, p < 0.01). Triglycerides were correlated with LPS in the combined cohort (r = 0.32, p < 0.01), and all subsets excluding the IU on ART subset. There were negative correlations between sCD14 and high-density lipoprotein (HDL) cholesterol in all subjects (r = -0.21, p < 0.01), as well as the IU subset not on ART (r = -0.32, p = 0.04). Large particle HDL as measured by NMR spectroscopy, but not HDL cholesterol, was negatively correlated with LPS (r = -0.18, p = 0.02), particularly among the IU subset receiving ART (r = -0.33, p = 0.03). In the combined cohorts, sCD14 was negatively correlated with lean mass as well as trunk and limb fat. There is a relationship between microbial translocation markers and metabolic effects, particularly lipoproteins. During prolonged ART, microbial translocation was associated with an adverse effect on large HDL and thus may contribute to the increased cardiovascular disease risk observed during chronic treatment of HIV.

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Coronary artery endothelial dysfunction is positively correlated with low density lipoprotein and inversely correlated with high density lipoprotein subclass particles measured by nuclear magnetic resonance spectroscopy

Cited by 30 publications

References 33 publications

High-Density Lipoprotein Quantity or Quality for Cardiovascular Prevention?

High-Density Lipoprotein Quantity or Quality for Cardiovascular Prevention?

Weight and inflammation are the major determinants of vascular dysfunction in the aortae of db/db mice

Microbial Translocation and Metabolic and Body Composition Measures in Treated and Untreated HIV Infection

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