Coronary Artery Risk Factors in Patients With Erectile Dysfunction

El‐Sakka, Ahmed I.; Morsy, Ayman M.; Fagih, Bassam I.; Nassar, Ahmed

doi:10.1097/01.ju.0000128572.31000.f0

Cited by 92 publications

(65 citation statements)

References 17 publications

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“…1 It is now well documented that many risk factors for coronary artery disease (CAD), such as hypertension, smoking, dyslipidemia, diabetes mellitus (DM) and lack of physical exercise, are also risk factors for ED. 2,3 These shared risk factors contribute to endothelial dysfunction and impede the ability of the arteries to dilate, thereby inhibiting the occurrence of normal erection. In addition, a strong and independent correlation between ED and silent CAD had been reported in uncomplicated type 2 diabetic patients by Gazzaruso et al 4 The authors found a higher ED prevalence in uncomplicated type 2 diabetic patients with, than those without, silent myocardial ischemia (33.8 vs 4.7%, P ¼ 0.000).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and cardiovascular disease risk differences for erectile dysfunction patients by three metabolic syndrome definitions

Chu

Pan

et al. 2011

Int J Impot Res

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There is growing evidence of a link between ED, metabolic syndrome (MS) and cardiovascular disease (CVD). The study was to explore the prevalence of MS using three different definitions (World Health Organization (WHO), International Diabetes Foundation (IDF) and Adult Treatment Panel III (ATP III)), and to compare the association of CVD in ED outpatients using these definitions. This study enrolled 254 participants with a mean age of 55.3±0.9 years (range, 21 to 81 years) with ED as diagnosed by International Index of Erectile Function score. All participants underwent MS evaluation based on the three criteria. Differences of MS prevalence, demographical characteristics, biochemical profiles, pro-inflammatory and inflammatory markers, echocardiographic characteristics and the association with Framingham cardiac risk score (FCRS) were compared. The presence of diabetes mellitus (DM) in the WHO group and high waist girth in the IDF group were significant because of the necessity of respective criteria. The MS prevalence in the WHO, IDF and ATP III groups was 30.7, 34.3 and 36.6%, respectively (P ¼ 0.367). The degrees of agreement among each definition were substantial to perfect. No significant findings in echocardiographic characteristics, biochemical, inflammatory and pro-inflammatory markers were noted. The FCRS showed borderline nonsignificant difference (17.9 ± 0.4, 16.8 ± 0.4 and 16.9 ± 0.4, P ¼ 0.079); however, the FCRS was more closely correlated with the WHO than with the IDF and ATP III (Spearman's correlation coefficients were 0.522, 0.531 and 0.462, respectively; P ¼ 0.021). In patients o 55 years of age and those who smoke, the Spearman's correlation in the WHO group was significantly higher than in the IDF and ATP III groups. The prevalence of the MS using different definitions in ED patients was not different. The WHO-defined MS was more closely associated with CVD.

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Section: Introductionmentioning

confidence: 99%

Prevalence and cardiovascular disease risk differences for erectile dysfunction patients by three metabolic syndrome definitions

Chu

Pan

et al. 2011

Int J Impot Res

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“…Further, several epidemiological studies have demonstrated that ED is more prevalent among men with atherosclerotic diseases, including coronary artery disease (CAD), than it is in the general population. [3][4][5] It is now well established that many risk factors for CAD (hypertension, smoking, dyslipidemia, diabetes mellitus (DM) and lack of physical exercise) are also risk factors for ED; 6,7 at least one significant cardiovascular risk factor occurs in most ED patients. [8][9][10] This could be attributed to the fact that both CAD and ED are characterized by endothelial dysfunction and injury.…”

Section: Introductionmentioning

confidence: 99%

Surveillance of cardiovascular risk factors for outpatients in different erectile dysfunction severity

Chu

et al. 2009

Int J Impot Res

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We determined the association between the severity of erectile dysfunction (ED) and traditional cardiovascular risk factors, including metabolic syndrome (MS). A total of 141 ED patients were divided into three groups on the basis of ED severity, which was determined using the International Index of Erectile Function (IIEF) scores. The prevalence of MS among the ED patients was 32.6%. Significantly lower IIEF scores were noted in patients with MS than in patients without MS (7.6±6.4 vs 11.6±7.4, P ¼ 0.003). As assessed by the anthropometric indices of body mass index, waist circumference and waist-to-hip ratio, obesity was detected in 58.9, 54.6 and 32.6% of the patients, respectively. Of the 141 patients, 39 had mild, 24 had moderate and 78 had severe ED. Statistically significant differences were noted among the different ED severity groups with regard to the presence of hypertension, systolic blood pressure, presence of MS and number of MS components. Multivariate analysis showed that the odds ratio for high-low-density lipoprotein (LDL) cholesterol level in moderate and severe ED, determined with reference to mild ED, were 9.346 and 6.452, respectively. The presence of MS, number of MS components, and certain traditional cardiovascular risk factors, particularly high-LDL cholesterol level and hypertension, may influence the severity of ED.

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“…Moreover, in that study, it was also reported that severity (not prevalence) of ED was associated with severity of CAD. El-sakka et al [24] conducted a study on 417 male patients, of whom 27.6% had mild ED, 30% had moderate ED, and 42.4% had severe ED. They also indicated a correlation between coronary artery risk factors and ED and reported a significant correlation between ischemic heart disease and the increased severity and progressive course of ED.…”

Section: Discussionmentioning

confidence: 99%

“…Angiograms of the patients were scored and divided into three groups according to the SS as low (SS ≤22), intermediate (SS between [23][24][25][26][27][28][29][30][31][32], and high (SS ≥33) [8]. After coronary angiography, erectile performance statuses of all patients were evaluated using the International Index of Erectile Function (IIEF), which is a validated 15-item self-administered questionnaire [10].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Erectile Dysfunction Severity and SYNTAX Score in Coronary Artery Disease

Tuna¹,

Kara²,

Argun³

et al. 2017

JCCR

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Coronary Artery Risk Factors in Patients With Erectile Dysfunction

Abstract: Coronary artery risk factors are significantly associated with erectile dysfunction. A significant association between higher degrees of IHD and the increased severity of ED was detected.

Cited by 92 publications

References 17 publications

Prevalence and cardiovascular disease risk differences for erectile dysfunction patients by three metabolic syndrome definitions

Prevalence and cardiovascular disease risk differences for erectile dysfunction patients by three metabolic syndrome definitions

Surveillance of cardiovascular risk factors for outpatients in different erectile dysfunction severity

Erectile Dysfunction Severity and SYNTAX Score in Coronary Artery Disease

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