Coronary artery rotation in native and stented porcine coronary arteries

Challa, Karthik; Kansal, Mayank; Frazin, Leon; Nikanorov, Alex; Kohler, Robert Ε.; Martinsen, Brad J.; Vidovich, Mladen I.

doi:10.1002/ccd.27247

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…While additional studies with a greater sample size are necessary to discern the true cause, it can be hypothesized that drug eluting stent technology utilizes a metal strut frame which inhibits a number of the native coronary vessel biomechanical forces. Previous studies have described a complex array of coronary vessel twisting, stretching, compression, and rotation during the normal cardiac cycle which may increase the risk of stent restenosis or fracture [1][2][3][4][5][6][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

“…In the human subject, coronary arteries are exposed to a number of various biomechanical forces during the normal cardiac cycle. Coronary twisting, stretching, compression, and rotation have all been described in various in vivo and in vitro studies [1][2][3][4][5][6]. It has been proposed that these biomechanical forces may have an effect on native coronary artery disease and the risk of stent failure in these patients [7].…”

Section: Introductionmentioning

confidence: 99%

“…Radial deformation is the compression and expansion of the coronary vessel lumen over a complete cardiac cycle, while radial velocity is the rate of change of this deformation per second. e objective benefit of these novel stents on the native biomechanical forces of coronary arteries of animal models, most commonly the porcine model, has been well established [5,[8][9][10]. Despite this research showing improvement for native vessel rotation in animal models, there remains a lack of a verified human model to measure radial deformation and velocity in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Coronary Artery Radial Deformation and Velocity in Native and Stented Arteries

Schwarzman

Griza

Frazin

et al. 2022

Journal of Interventional Cardiology

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Introduction. Coronary arteries are exposed to a variety of complex biomechanical forces during a normal cardiac cycle. These forces have the potential to contribute to coronary stent failure. Recent advances in stent design allow for the transmission of native pulsatile biomechanical forces in the stented vessel. However, there is a significant lack of evidence in a human model to measure vessel motion in native coronary arteries and stent conformability. Thus, we aimed to characterize and define coronary artery radial deformation and the effect of stent implantation on arterial deformation. Materials and Methods. Intravascular ultrasound (IVUS) pullback DICOM images were obtained from human coronary arteries using a coronary ultrasound catheter. Using two-dimensional speckle tracking, coronary artery radial deformation was defined as the inward and outward displacement (mm) and velocity (cm/s) of the arterial wall during the cardiac cycle. These deformation values were obtained in native and third-generation drug-eluting stented artery segments. Results. A total of 20 coronary artery segments were independently analyzed pre and poststent implantation for a total of 40 IVUS runs. Stent implantation impacted the degree of radial deformation and velocity. Mean radial deformation in native coronary arteries was 0.1230 mm ± 0.0522 mm compared to 0.0775 mm ± 0.0376 mm in stented vessels ( p = 0.0031 ). Mean radial velocity in native coronary arteries was 0.1194 cm/s ± 0.0535 cm/s compared to 0.0840 cm/s ± 0.0399 cm/s in stented vessels ( p = 0.0228 ). Conclusion. In this in vivo analysis of third-generation stents, stent implantation attenuates normal human coronary deformation during the cardiac cycle. The implications of these findings on stent failure and improved clinical outcomes require further investigation.

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