Coronary atherosclerosis in middle‐aged athletes: Current insights, burning questions, and future perspectives

Aengevaeren, Vincent L.; Eijsvogels, Thijs M. H.

doi:10.1002/clc.23340

Cited by 13 publications

(14 citation statements)

References 43 publications

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“…In addition, the plaque in atherosclerosis can also harm the arterial endothelium. Repeated injuries can cause inflammation and trigger atherosclerosis blockage [30]. As a result, atherosclerosis blockage increases the risk of heart attack and stroke [31].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Disease Risk Profiles in Indonesian Athletes

Achmad

Alim

Kusumawati

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Notwithstanding how physical exercise lessens cardiovascular and all-cause mortality, young and active athletes might have cardiovascular risk factors or fundamental cardiovascular diseases (CVDs), putting them at increased risk for sudden cardiac death during times of strenuous exercise. AIM: The study aimed to assess the cardiovascular risk profile possessed by Indonesian athletes. METHODS: This research was a quantitative study using a cross-sectional design, involving 234 Indonesian athletes (163 men and 71 women) from three sports, including football, basketball, and swimming. Data were collected between December 2020 to March 2021 using the Jakarta Cardiovascular Risk Score instrument adapted from the Framingham risk score. Descriptive statistics were utilized to dissect data information for frequency distribution, percentage, mean, and standard deviation. RESULTS: Most of the participants in this study had excessive weekly exercise duration (more than 255 minutes/week) (n=177 athletes, 75.64%). Twenty-one participants (8.97%) had a higher MAP more than normal, and 51 participants (21.79%) had overweight BMI. In addition, 142 participants (60.68%) had a cardiovascular genetic disease from their parents (family history) and most of the participants also were active smokers (n=150, 64.10%). Based on the Jakarta Cardiovascular Risk Score, the Indonesian athletes who participated in this study had a mean cardiovascular risk of -1.5 (SD= 3.088, min-max= (-7) – 6). Most of the participants had low cardiovascular risk (n= 193, 82.48%). However, some participants had moderate and high cardiovascular risk, 32 (13.67%) and 9 (3.85%), respectively. CONCLUSION: Most of the participants had low cardiovascular risk, however some of the participants had moderate and high cardiovascular risk.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular Disease Risk Profiles in Indonesian Athletes

Achmad

Alim

Kusumawati

et al. 2022

Open Access Maced J Med Sci

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“…While PA and exercise are unlikely to increase the risk of coronary artery calcification (CAC) at the general population level, extreme endurance ET (such as long-term marathon running) may confer an increased risk of higher CAC in a small percentage of athletes. 85 In a cross-sectional analysis of 108 healthy marathon runners ≥50 years who had completed 5 or more marathons in the preceding 3 years, the percentage of marathon runners with a CAC score ≥≥100 Agatston units (AU) was significantly greater than age- and risk factor-matched controls (36.1% versus 21.8%, P = 0.01). 86 Another small cross-sectional study of 152 masters athletes (77% runners, median 13 lifetime marathons per athlete) with a low 10-year ASCVD risk profile found that masters athletes were more likely to have a CAC score ≥300 AU compared with age- and risk factor-matched sedentary controls (11.3% versus 0%, P = 0.009).…”

Section: Primary Prevention Of Ascvdmentioning

confidence: 98%

Exercise, Physical Activity, and Cardiometabolic Health: Insights into the Prevention and Treatment of Cardiometabolic Diseases

Rao

Belanger

Robbins

2021

Cardiology in Review

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Physical activity (PA) and exercise are widely recognized as essential components of primary and secondary cardiovascular disease (CVD) prevention efforts and are emphasized in the health promotion guidelines of numerous professional societies and committees. The protean benefits of PA and exercise extend across the spectrum of CVD, and include the improvement and reduction of risk factors and events for atherosclerotic CVD (ASCVD), cardiometabolic disease, heart failure, and atrial fibrillation (AF), respectively. Here, we highlight recent insights into the salutary effects of PA and exercise on the primary and secondary prevention of ASCVD, including their beneficial effects on both traditional and nontraditional risk mediators; exercise “prescriptions” for ASCVD; the role of PA regular exercise in the prevention and treatment of heart failure; and the relationships between, PA, exercise, and AF. While our understanding of the relationship between exercise and CVD has evolved considerably, several key questions remain including the association between extreme volumes of exercise and subclinical ASCVD and its risk; high-intensity exercise and resistance (strength) training as complementary modalities to continuous aerobic exercise; and dose- and intensity-dependent associations between exercise and AF. Recent advances in molecular profiling technologies (ie, genomics, transcriptomics, proteomics, and metabolomics) have begun to shed light on interindividual variation in cardiometabolic responses to PA and exercise and may provide new opportunities for clinical prediction in addition to mechanistic insights.

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“…Diperkirakan diseluruh dunia, PJK pada tahun 2020 menjadi pembunuh pertama tersering yakni sebesar 36% dari seluruh kematian, angka ini dua kali lebih tinggi dari angka kematian akibat penyakit kanker (PERKI 2019). Kematian akibat CVD disebabkan oleh penyakit jantung koroner aterosklerotik (Aengevaeren & Eijsvogels, 2020).…”

Section: Pendahuluanunclassified

Pengaruh Latihan Teratur Terhadap Kadar Circulating Endothelial Cells (Cec) Tikus Strain Wistar

Kinanti¹,

Abdullah²,

Yunus³

2022

sporta

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Circulating endothelial cells (CEC) di identifikasi sebagai penanda kerusakan vaskular pada beberapa penyakit, salah satunya penyakit jantung koroner aterosklerosis. Penelitian ini bertujuan untuk melihat pengaruh latihan teratur terhadap kadar CEC. Sampel yang digunakan adalah tikus jantan berjenis rattus norvegicus strain wistar, usia 8-10 minggu, berat badan 80-110 gram. Tikus sehat diambil dari peternakan khusus yang direkomendasikan. Sampel keseluruhan berjumlah 10 ekor dibagi menjadi dua kelompok, kelompok kontrol berjumlah 5 ekor dan kelompok perlakuan olahraga teratur berjumlah 5 ekor. Perlakuan olahraga teratur (tikus direnangkan) selama 12 minggu. Temuan dari penelitian ini adalah pemberian latihan teratur dapat mempengaruhi jumlah Circulating Endothelial Cells (CEC), namun penurunannya tidak signifikan (p=0.116) dibanding kelompok kontrol. Latihan teratur meningkatkan fungsi endotel, ditandai dengan penurunan jumlah CEC.

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Coronary atherosclerosis in middle‐aged athletes: Current insights, burning questions, and future perspectives

Cited by 13 publications

References 43 publications

Cardiovascular Disease Risk Profiles in Indonesian Athletes

Cardiovascular Disease Risk Profiles in Indonesian Athletes

Exercise, Physical Activity, and Cardiometabolic Health: Insights into the Prevention and Treatment of Cardiometabolic Diseases

Pengaruh Latihan Teratur Terhadap Kadar Circulating Endothelial Cells (Cec) Tikus Strain Wistar

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