Coronary atherosclerotic lesions in human immunodeficiency virus–infected patients: a histopathologic study

Abstract

Young to middle-aged patients dying from advanced AIDS have atherosclerotic CAD that may result in luminal narrowing, heavy calcification, and high plaque lipid content. The pattern of disease, location of lesions, and plaque composition are typical of atherosclerosis in HIV-negative patients. No relationship between antiretroviral therapies and atherosclerosis was seen in this small study of heavily treated patients.

Serum calcium revisited: associations with 24-h ambulatory blood pressure and cardiovascular reactivity in Africans

“…In addition, because it is known that a HIV-positive status is associated with cardiovascular effects, 29 eight younger and five older HIV-positive men were also excluded. By doing so, our associations not only remained consistent but were also strengthened (Table 4).…”

Metalloproteinases and Brain Arterial Remodeling Among Individuals With and Those Without HIV Infection

“…Although the rise in cardiac disease frequency among HIV-infected individuals has been attributed to increased atherosclerotic burden, stroke mechanisms remain less well understood [2]. Stroke is a heterogeneous disease in which the mechanisms dictate natural history and, in some cases, also dictate the preventive measures to reduce the risk of recurrence [3].…”

Noninvasive Assessment of HIV-related Coronary Artery Disease

“…In a comparative histopathologic study of young deceased patients with end-stage HIV disease, Micheletti et al [25] demonstrated a greater burden of CAD and heavy coronary artery calcification in HIV-infected patients when compared to HIV-negative controls who died from other chronic illnesses. Two previously unreported patterns of dystrophic coronary calcification were described in both HIV-positive patients and older HIV-negative controls, suggesting coronary artery calcium might be a useful surrogate of the accelerated atherosclerotic process found in HIV patients [25].…”