Coronary calcification and its relation to extracoronary atherosclerosis in asymptomatic hypercholesterolemic men. The PCV METRA Group.

Mégnien, Jean-Louis; Sene, V.; Jeannin, Sophie; Hernigou, A.; Plainfossé, M. C.; Merli, I.; Atger, V.; Moatti, N.; Levenson, Jaime; Simon, Alain

doi:10.1161/01.cir.85.5.1799

Cited by 85 publications

(31 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24,28 LDL (dϭ1.019 to 1.063 g/mL) was isolated by sequential ultracentrifugation in a Beckman L90 ultracentrifuge (Beckman Instruments Inc) according to a procedure previously described in detail. 24 Collected LDL was dialyzed for 24 hours at ϩ4°C against four changes of 100 vol 10 mmol/L Tris-HCl buffer, pH 7.4, containing 1 mmol/L EDTA, and was stored at ϩ4°C in the dark.…”

Section: Methodsmentioning

confidence: 99%

Sialic Acid Content of LDL in Coronary Artery Disease: No Evidence of Desialylation in Subjects With Coronary Stenosis and Increased Levels in Subjects With Extensive Atherosclerosis and Acute Myocardial Infarction

Chappey

Beyssen

Foos

et al. 1998

ATVB

View full text Add to dashboard Cite

Abstract-We recently showed that sialic acid content of LDL was not a marker of early cardiovascular disease (Arterioscler Thromb Vasc Biol. 1995;15:334 -339). Here, we investigated this parameter in patients with advanced coronary artery disease (CAD). We first examined 100 patients having undergone coronary angiography. The distribution of LDL sialic acid values was very similar in subjects with no coronary stenosis (31.3Ϯ3.7 nmol/mg LDL protein, meanϮSD) and those with Ն75% stenosis in at least one main coronary artery or Ն50% stenosis in at least two main coronary arteries (32.1Ϯ5.5 nmol/mg LDL protein). In contrast, LDL sialic acid content was significantly increased in patients with both coronary stenosis and peripheral arterial atherosclerotic lesions compared with those with either no lesion or only one or the other type of lesion. We then examined LDL sialic acid content in 20 patients with acute myocardial infarction. LDL sialic acid content was significantly higher (35.9Ϯ3.2 nmol/mg LDL protein) than that in the CAD(Ϫ) control group. These data suggest that LDL sialic acid content increases with the extension of atherosclerosis and its progression to acute complications. To explain the discordance with Orekhov and coworkers (Atherosclerosis. 1991;86:153-161), who showed that LDL sialic acid content in patients with advanced CAD was lower than that in healthy subjects, we studied the time courses of sialic acid, TBARS, and vitamin E levels in LDL dialyzed in different experimental conditions. A continuous decrease in both sialic acid and vitamin E levels and an increase in TBARS levels were observed in LDL samples containing less than 1 mmol/L EDTA, the intensity and rapidity of which varied with the EDTA concentration in the buffer. Our data support the idea that desialylation may result from in vitro peroxidation of LDL. (Arterioscler Thromb Vasc Biol. 1998;18:876-883.)

show abstract

Section: Methodsmentioning

confidence: 99%

Sialic Acid Content of LDL in Coronary Artery Disease: No Evidence of Desialylation in Subjects With Coronary Stenosis and Increased Levels in Subjects With Extensive Atherosclerosis and Acute Myocardial Infarction

Chappey

Beyssen

Foos

et al. 1998

ATVB

View full text Add to dashboard Cite

show abstract

“…This finding is probably attributable to the examination of several territories, including vascular areas more susceptible to disease such as the iliofemoral arteries, which were not explored in earlier studies. Other studies that investigated multiple vascular sites included only men with at least 1 risk factor, 21 examined participants at higher risk, 22 or explored fewer territories. 23 An innovation of PESA is the early detection of atherosclerosis in other vascular territories even in the absence of CAC.…”

Section: Subclinical Atherosclerosis Is Prevalent In Middleaged Indivmentioning

confidence: 99%

Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort

et al. 2015

View full text Add to dashboard Cite

Background-Data are limited on the presence, distribution, and extent of subclinical atherosclerosis in middle-aged populations. Methods and Results-The PESA (Progression of Early Subclinical Atherosclerosis) study prospectively enrolled 4184 asymptomatic participants 40 to 54 years of age (mean age, 45.8 years; 63% male) to evaluate the systemic extent of atherosclerosis in the carotid, abdominal aortic, and iliofemoral territories by 2-/3-dimensional ultrasound and coronary artery calcification by computed tomography. The extent of subclinical atherosclerosis, defined as presence of plaque or coronary artery calcification ≥1, was classified as focal (1 site affected), intermediate (2-3 sites), or generalized (4-6 sites) after exploration of each vascular site (right/left carotids, aorta, right/left iliofemorals, and coronary arteries). Subclinical atherosclerosis was present in 63% of participants (71% of men, 48% of women). Intermediate and generalized atherosclerosis was identified in 41%. Plaques were most common in the iliofemorals (44%), followed by the carotids (31%) and aorta (25%), whereas coronary artery calcification was present in 18%. Continuing medical education (CME) credit is available for this article. Go to http://cme.ahajournals.org to take the quiz.

show abstract

“…Blood pressure at follow-up and presence of atherosclerosis The age-adjusted relative risk of advanced atherosclerosis compared with the reference group (75-84 mm Hg) was [1][2][3][4][5][6] (0-8-3-0) for the lowest blood pressure category (< 75 mm Hg), [1][2][3][4][5][6][7] (0-9-3-1) for 85-94 mm Hg, and 3-7 (1-6-8-7) for more than 95 mm Hg. The association was also examined among women on antihypertensive medication at follow-up (n = 203).…”

Section: Introductionmentioning

confidence: 99%

J-shaped relation between change in diastolic blood pressure and progression of aortic atherosclerosis

1994

View full text Add to dashboard Cite

SummaryThe J-shaped relation between diastolic blood pressure and mortality from coronary heart disease continues to provoke controversy. We examined the association between diastolic blood pressure and progression of aortic atherosclerosis in a population-based cohort of 855 women, aged 45-64 years at baseline. The women were examined radiographically for calcified deposits in the abdominal aorta, which have been shown to reflect intimal atherosclerosis.After 9 years of follow-up, slight progression of atherosclerosis was noted in 19% of women and substantial progression in 16%. The age-adjusted relative risk of substantial atherosclerotic progression in women with a decrease in diastolic pressure of 10 mm Hg or more was 2·5 (95% CI 1·3-5·6), compared with the reference group of women who had a smaller decrease or no change. The excess risk in this group was confined to women whose increase in pulse pressure was above the median (3·9 [1·5-9·9] vs 1·1 [0 3-4·2] in women with an increase in pulse pressure below the median). The relative risks for women with rises in diastolic pressure of 1-9 mm Hg and 10 mm Hg or more were 2·2 (1 1-4 3) and 3·5 (1 6-8 0), respectively.These findings suggest that a decline in diastolic blood pressure indicates vessel wall stiffening associated with atherosclerotic progression. They support the hypothesis that in low-risk subjects progression of atherosclerosis may be accompanied by a decrease in diastolic blood pressure rather than the opposing idea that low diastolic blood pressure precipitates the occurrence of atherosclerotic events.

show abstract

Coronary calcification and its relation to extracoronary atherosclerosis in asymptomatic hypercholesterolemic men. The PCV METRA Group.

Abstract: The close relation between coronary calcium and extracoronary plaques suggests that echography of extracoronary vessels could aid in the screening of coronary atherosclerosis in high-risk, asymptomatic individuals.

Cited by 85 publications

References 28 publications

Sialic Acid Content of LDL in Coronary Artery Disease: No Evidence of Desialylation in Subjects With Coronary Stenosis and Increased Levels in Subjects With Extensive Atherosclerosis and Acute Myocardial Infarction

Sialic Acid Content of LDL in Coronary Artery Disease: No Evidence of Desialylation in Subjects With Coronary Stenosis and Increased Levels in Subjects With Extensive Atherosclerosis and Acute Myocardial Infarction

Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort

J-shaped relation between change in diastolic blood pressure and progression of aortic atherosclerosis

Contact Info

Product

Resources

About