Coronary Circulation and Hemodynamics

Spaan, Jos A. E.; Piek, Jan J.; Siebes, Maria

doi:10.1016/b978-012656975-9/50004-3

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…from 80 to 90%). With such narrowing autoregulation will soon be exhausted, and any subsequent small reduction will have major hemodynamic consequences [20]. Clinically, a stenosis of the LAD <75% will reduce maximal flow capacity, causing ischemic induced chest pain during exertion.…”

Section: Discussionmentioning

confidence: 98%

Different graft flow patterns due to competitive flow or stenosis in the coronary anastomosis assessed by transit-time flowmetry in a porcine model☆☆☆

Nordgaard

Nordhaug

Kirkeby‐Garstad

et al. 2009

European Journal of Cardio-Thoracic Surgery

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Section: Discussionmentioning

confidence: 98%

Different graft flow patterns due to competitive flow or stenosis in the coronary anastomosis assessed by transit-time flowmetry in a porcine model☆☆☆

Nordgaard

Nordhaug

Kirkeby‐Garstad

et al. 2009

European Journal of Cardio-Thoracic Surgery

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“…The present study had chosen to measure the CPP as it was easier to monitor, sensitive to changes in coronary flow 20 and was directly proportionate to vascular resistance. 25 The cardiac function was observed through the LVDP to measure the isometric tension developed by the left ventricle (LV) as previously reported. 26 LVDP was represented by the cyclic height which is the height of one complete waveform or similar to a calculation of left ventricular end systolic pressure (LVESP) minus left ventricular end diastolic pressure (LVEDP).…”

Section: Data Acquisitionmentioning

confidence: 99%

Effects of Eurycoma Longifolia Extract on the Isolated Rat Heart

Mokhtar¹,

Abdullah²,

Ayob

2014

imjm

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Introduction: Eurycoma longifolia (E. longifolia) which is better known locally as Tongkat Ali is an indigenous plant in Malaysia. It belongs to the family of Simaroubaceae and is popular as a traditional medicine for its aphrodisiac properties. Throughout the years, several studies have been conducted to prove its effect on aphrodisiac action, antimalarial, antibacterial and anxiolytic properties but its effect to the cardiovascular system had not been fully explored. This study was aimed to demonstrate the changes that take place in the isolated heart following the injection of the extract. Methods: Three parameters that were measured included the coronary perfusion pressure (CPP), the left ventricular developed pressure (LVDP) and the heart rate (HR). Eighteen isolated rat hearts were used and were divided equally into three groups. The first group was to observe the effect of Isoprenaline, a β agonist while the second group was to see the effect of sodium nitroprusside (SNP), a nitric oxide (NO) donor. The dose which gave the maximum effect for these two positive controls was used to compare with the effect of E. longifolia water extract in the third group of rats. Isolated heart was mounted using the Langendorff apparatus and perfused with modified Krebs-Henseleit buffer. Doses of controls and the extract were instilled through an injection port, and the effect of each dose was monitored. Results: E. longifolia extract was found to reduce the CPP in normotensive rat at two of the highest doses. A dose of 1.0 mg of the extract reduced the CPP significantly from 34.52 ± 4.99 mmHg of the baseline value to 31.99 ± 4.93 mmHg while the dose of 10.0 mg of the extract reduced the CPP significantly to 32.67 ± 3.89 mmHg. However, there were no significant changes of effect of the extract on the LVDP and HR as compared to control. Conclusion: These early findings suggest that E. longifolia extract may have vasodilatory property, which supports its traditional usage with minimum cardiovascular side effects.

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“…Pulsatile arterial blood flow has been shown to have inherent properties that are integral to the normal function of specific organ and tissue systems [ 1 , 2 ]. The ability to generate pulsatile flow is important in the development of in-vitro models to simulate real-life conditions.…”

Section: Introductionmentioning

confidence: 99%

Applications of a novel reciprocating positive displacement pump in the simulation of pulsatile arterial blood flow

et al. 2022

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Pulsatile arterial blood flow plays an important role in vascular system mechanobiology, especially in the study of mechanisms of pathology. Limitations in cost, time, sample size, and control across current in-vitro and in-vivo methods limit future exploration of novel treatments. Presented is the verification of a novel reciprocating positive displacement pump aimed at resolving these issues through the simulation of human ocular, human fingertip and skin surface, human cerebral, and rodent spleen organ systems. A range of pulsatile amplitudes, frequencies, and flow rates were simulated using pumps made of 3D printed parts incorporating a tubing system, check valve and proprietary software. Volumetric analysis of 430 total readings across a flow range of 0.025ml/min to 16ml/min determined that the pump had a mean absolute error and mean relative error of 0.041 ml/min and 1.385%, respectively. Linear regression analysis compared to expected flow rate across the full flow range yielded an R2 of 0.9996. Waveform analysis indicated that the pump could recreate accurate beat frequency for flow ranges above 0.06ml/min at 70BPM. The verification of accurate pump output opens avenues for the development of novel long-term in-vitro benchtop models capable of looking at fluid flow scenarios previously unfeasible, including low volume-high shear rate pulsatile flow.

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Coronary Circulation and Hemodynamics

Cited by 8 publications

References 52 publications

Different graft flow patterns due to competitive flow or stenosis in the coronary anastomosis assessed by transit-time flowmetry in a porcine model☆☆☆

Different graft flow patterns due to competitive flow or stenosis in the coronary anastomosis assessed by transit-time flowmetry in a porcine model☆☆☆

Effects of Eurycoma Longifolia Extract on the Isolated Rat Heart

Applications of a novel reciprocating positive displacement pump in the simulation of pulsatile arterial blood flow

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