Journal of Cardiovascular Computed Tomography

2013

DOI: 10.1016/j.jcct.2013.08.006

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Coronary CT angiography versus intravascular ultrasound for estimation of coronary stenosis and atherosclerotic plaque burden: A meta-analysis

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Literature Review Based On Systematic Review and Meta-2

Relationship Between Anatomical Coronary Stenosis and Plaque1

Mdct Scan Protocol1

Introduction1

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Cited by 107 publications

(70 citation statements)

References 60 publications

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“…Their results were limited by the small sample sizes and methodological flaws in the studies reviewed. Recent reports with inclusion of more studies have confirmed the reliable diagnostic accuracy of CCTA for detection of coronary plaques [54][55][56].…”

Section: Literature Review Based On Systematic Review and Meta-mentioning

confidence: 97%

“…There are one systematic review and three metaanalysis reports available in the literature with regard to the diagnostic value of CCTA in detecting coronary plaques [53][54][55][56]. Springer and Dewey in their early systematic review reported that CCTA has the potential to become a useful diagnostic tool for the analysis of coronary plaques when compared to IVUS, based an analysis of 9 studies [53].…”

Section: Literature Review Based On Systematic Review and Meta-mentioning

confidence: 99%

See 1 more Smart Citation

Coronary CT Angiography: Quantitative Assessment of Coronary Plaques

2018

Coronary CT Angiography in the Quantitative Analysis of Coronary Plaques

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Coronary computed tomography angiography (CCTA) has been recently evaluated for its ability to assess coronary plaque characteristics, including plaque composition. Identification of the relationship between plaque composition by CCTA and patient clinical presentations may provide insight into the pathophysiology of coronary artery plaque, thus assisting identification of vulnerable plaques which are associated with the development of acute coronary syndrome. CCTA-generated 3D visualizations allow evaluation of both coronary lesions and lumen changes, which are considered to enhance the diagnostic performance of CCTA. The purpose of this review is to discuss the recent developments that have occurred in the field of CCTA with regard to its diagnostic accuracy in the quantitative assessment of coronary plaques, with a focus on the characterization of plaque components and identification of vulnerable plaques.

“…Their results were limited by the small sample sizes and methodological flaws in the studies reviewed. Recent reports with inclusion of more studies have confirmed the reliable diagnostic accuracy of CCTA for detection of coronary plaques [54][55][56].…”

Section: Literature Review Based On Systematic Review and Meta-mentioning

confidence: 97%

“…There are one systematic review and three metaanalysis reports available in the literature with regard to the diagnostic value of CCTA in detecting coronary plaques [53][54][55][56]. Springer and Dewey in their early systematic review reported that CCTA has the potential to become a useful diagnostic tool for the analysis of coronary plaques when compared to IVUS, based an analysis of 9 studies [53].…”

Section: Literature Review Based On Systematic Review and Meta-mentioning

confidence: 99%

Coronary CT Angiography: Quantitative Assessment of Coronary Plaques

2018

Coronary CT Angiography in the Quantitative Analysis of Coronary Plaques

View full text Add to dashboard Cite

Coronary computed tomography angiography (CCTA) has been recently evaluated for its ability to assess coronary plaque characteristics, including plaque composition. Identification of the relationship between plaque composition by CCTA and patient clinical presentations may provide insight into the pathophysiology of coronary artery plaque, thus assisting identification of vulnerable plaques which are associated with the development of acute coronary syndrome. CCTA-generated 3D visualizations allow evaluation of both coronary lesions and lumen changes, which are considered to enhance the diagnostic performance of CCTA. The purpose of this review is to discuss the recent developments that have occurred in the field of CCTA with regard to its diagnostic accuracy in the quantitative assessment of coronary plaques, with a focus on the characterization of plaque components and identification of vulnerable plaques.

“…studies revealed that sensitivity and specificity of coronary CTA to detect any plaque and that of intravascular ultrasound were 93% and 92%, respectively, with an area under the receiver-operating curve of 0.97 (13).…”

Section: Relationship Between Anatomical Coronary Stenosis and Plaquementioning

confidence: 99%

Plaque Imaging Using Coronary Computed Tomography Angiography

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2018

Annals of Nuclear Cardiology

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Coronary computed tomography angiography (CCTA) is the most commonly used modality for noninvasive plaque imaging in clinical settings. Characteristics of rupture-prone vulnerable plaques include positive remodeling, low attenuation, and napkin-ring sign in CCTA. About 60% of all vulnerable plaques have these characteristics, and these coronary lesions often result in plaque rupture. Identification of such groupings of coronary artery characteristics has been used to predict cardiovascular events. Keywords

“…MDCT has high spatial resolution and is the only non-invasive modality able to delineate plaque composition. It has been validated against virtual histology-intravascular ultrasound (VH-IVUS), which is considered to be the reference method for assessment of coronary plaque composition [7,8]. Interestingly, several reports have suggested that plaque morphology may vary depending on clinical presentation of CAD: Non-calcified plaque seems to be directly linked to the development of acute coronary syndrome (ACS) while calcified plaque seems to be a marker of disease burden and does not appear to be involved in the mechanism of acute ischemic events [9][10][11].…”

Section: Mdct Scan Protocolmentioning

confidence: 99%

Reproducibility of coronary atherosclerotic plaque characteristics in populations with low, intermediate, and high prevalence of coronary artery disease by multidetector computer tomography: a guide to reliable visual coronary plaque assessments

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et al. 2016

Int J Cardiovasc Imaging

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To evaluate the interobserver agreement of visual coronary plaque characteristics by 320-slice multidetector computed tomography (MDCT) in three populations with low, intermediate and high CAD prevalence and to identify determinants for the reproducible assessment of these plaque characteristics. 150 patients, 50 asymptomatic subjects from the general population (low CAD prevalence), 50 symptomatic non-acute coronary syndrome (non-ACS) patients (intermediate CAD prevalence), and 50 ACS patients (high CAD prevalence), matched according to age and gender, were retrospectively enrolled. All coronary segments were evaluated for overall image quality, evaluability, presence of CAD, coronary stenosis, plaque composition, plaque focality, and spotty calcification by four readers. Interobserver agreement was assessed using Fleiss' Kappa (κ) and intra-class correlation (ICC). Widely used clinical parameters (overall scan quality, presence of CAD, and determination of coronary stenosis) showed good agreement among the four readers, (ICC = 0.66, κ = 0.73, ICC = 0.74, respectively). When accounting for heart rate, body mass index, plaque location, and coronary stenosis above/below 50 %, interobserver agreement for plaque composition, presence of CAD, and coronary stenosis improved to either good or excellent, (κ = 0.61, κ = 0.81, ICC = 0.78, respectively). Spotty calcification was the least reproducible parameter investigated (κ = 0.33). Across subpopulations, reproducibility of coronary plaque characteristics generally decreased with increasing CAD prevalence except for plaque composition, (limits of agreement: ±2.03, ±1.96, ±1.79 for low, intermediate and high CAD prevalence, respectively). 320-slice MDCT can be used to assess coronary plaque characteristics, except for spotty calcification. Reproducibility estimates are influenced by heart rate, body size, plaque location, and degree of luminal stenosis.

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