Coronary Disease Risk Curve of Serum Creatinine is Linear in Turkish Men, U-Shaped in Women

Onat, Altan; Can, Günay; Ademoğlu, Evin; Çelik, Etem; Karagöz, Ahmet; Örnek, Ender

doi:10.2310/jim.0b013e318276de59

Cited by 27 publications

(25 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An association between serum ADMA and endothelial function was lacking also in patients with rheumatoid arthritis (34). From the distribution of apoB-containing lipoproteins and the positive linear association of serum creatinine with ADMA, it may be considered that both creatinine (35,36) and lipoprotein(a) (37) may have been further involved in the autoimmune complex formation in this sample, as previously shown by us to confer incident CHD risk.…”

Section: Adma Levels Influenced By Enhanced Inflammation Affects Glsupporting

confidence: 54%

Apparently “low” serum asymmetric dimethylarginine is associated with fasting glucose and tends toward association with type-2 diabetes

Onat¹,

Köroğlu²,

Can³

et al. 2013

Anadolu Kardiyol Derg

Self Cite

View full text Add to dashboard Cite

Objective: We investigated the association of serum asymmetric dimethylarginine (ADMA) with metabolic syndrome (MetS), type-2 diabetes and coronary heart disease (CHD) in the general population. Methods: Cross-sectional and, at 2000 person-years' follow-up, prospective analysis. Adults with measured serum ADMA level (n=848) were analyzed using tertiles or dichotomized values. ADMA concentrations were measured by a validated commercial ELISA kit. Results: Dichotomized subjects of combined sexes with low (≤0.68 μmol/L) ADMA values had significantly higher fasting glucose, total cholesterol, apolipoprotein B and lower diastolic blood pressure. In linear regression analyses comprising age, smoking, triglyceride, HDL-cholesterol, C-reactive protein and waist circumference as well, creatinine was significantly and independently associated with ADMA, further in women glucose (inversely). In logistic regression analyses uniformly adjusted for age, smoking status and waist girth, prevalent MetS tended to positive independent association with ADMA tertiles only in men. Combined prevalent and incident diabetes weakly tended to be associated with the lowest (vs mid-and highest) ADMA tertiles in combined gender; and prevalent and incident CHD was not associated with ADMA tertiles in either sex. Conclusion: Apparently "low" circulating ADMA is independently associated with fasting glucose and tends to be so with type-2 diabetes. The lack of anticipated positive associations of ADMA with cardiometabolic disorders is likely due to autoimmune responses operating against serum ADMA under oxidative stress, rendering partial failure in immunoassay. (Anadolu Kardiyol Derg 2014; 14: 26-33)

show abstract

Section: Adma Levels Influenced By Enhanced Inflammation Affects Glsupporting

confidence: 54%

Apparently “low” serum asymmetric dimethylarginine is associated with fasting glucose and tends toward association with type-2 diabetes

Onat¹,

Köroğlu²,

Can³

et al. 2013

Anadolu Kardiyol Derg

Self Cite

View full text Add to dashboard Cite

show abstract

“…This is consistent with a setting in which high adiponectin levels in a subset of the female sample were converted pro-oxidative to mediate endothelial dysfunction, acquiring attenuated atheroprotective effects, concomitantly with a reduced glomerular filtration rate. In view of our recent reports of higher CHD risk in women in the bottom creatinine quartile compared with the two intermediate quartiles [23,24] , immune complex formation with adiponectin may be suggested.…”

Section: Sex-specific Positive Association With Serum Creatininementioning

confidence: 90%

High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?

Onat¹,

Aydın²,

Can³

et al. 2013

WJD

Self Cite

View full text Add to dashboard Cite

AIM:To investigate whether serum adiponectin protects against cardiometabolic risk in a population sample with prevailing metabolic syndrome. METHODS:Middle-aged adults representative of a general population with baseline circulating adiponectin measurements (n = 1224) were analyzed prospectively at a mean of 3.8 years' follow-up, using continuous values or sex-specific tertiles. Total adiponectin was assayed by an ELISA kit. Type-2 diabetes was identified by criteria of the American Diabetes Association. Hypertension was defined as a blood pressure ≥ 140 mmHg and/or ≥ 90 mmHg and/or use of antihypertensive medication. Outcomes were predicted using Cox proportional hazards regression analysis in models that were controlled for potential confounders. RESULTS:In models of multiple linear regression, sex hormone-binding globulin, fasting insulin (inverse) and, in men, age were significant independent covariates of serum adiponectin which further tended in women to be positively associated with serum creatinine. Cox regression analyses for incident coronary heart disease (CHD), adjusted for sex, age, non-HDL cholesterol, waist circumference and C-reactive protein, revealed significant inverse association with adiponectin tertiles in men but not women (HR = 0.66; 95%CI: 0.32-1.38 for highest tertile). Cox regression for type-2 diabetes in a similar model (wherein glucose replaced non-HDL cholesterol), adiponectin tertiles appeared to protect in each gender. HR for incident hypertension roughly displayed unity in each of the adiponectin tertiles (P -trend = 0.67). CONCLUSION:High adiponectin levels failed to protect against the development of hypertension and, in women, against CHD, presumably paralleling impairment in renal function as well. Involvement of adiponectin in autoimmune complex with loss of antioxidative-antiatherogenic properties may be underlying.

show abstract

“…This may again manifest itself in one sex in the general population. Increasing serum creatinine values were strongly associated with CHD risk in men but not in women in whom the risk curve was U-shaped [19]. In the prediction of incident type-2 diabetes risk by baseline estimated glomerular filtration rate in the Insulin Resistance Atherosclerosis Study, other than the bottom quintile, the top estimated glomerular filtration rate quintile disclosed excess multi-adjusted risk compared with the referent 4th quintile [21].…”

Section: Journal Of Clinical and Cellular Immunologymentioning

confidence: 89%

“…Low serum creatinine levels (<0.7/<0.8 mg/dl) may represent a clue to the existence of autoimmune activation [19,20]. This may again manifest itself in one sex in the general population.…”

Section: Journal Of Clinical and Cellular Immunologymentioning

confidence: 99%

Underlying Autoimmune Activation Rendering Paradoxical Non-Linear Relationship between Biomarkers and Cardiometabolic Risk

Onat¹,

Kaya²

2016

J Clin Cell Immunol

Self Cite

View full text Add to dashboard Cite

Coronary Disease Risk Curve of Serum Creatinine is Linear in Turkish Men, U-Shaped in Women

Cited by 27 publications

References 29 publications

Apparently “low” serum asymmetric dimethylarginine is associated with fasting glucose and tends toward association with type-2 diabetes

Apparently “low” serum asymmetric dimethylarginine is associated with fasting glucose and tends toward association with type-2 diabetes

High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?

Underlying Autoimmune Activation Rendering Paradoxical Non-Linear Relationship between Biomarkers and Cardiometabolic Risk

Contact Info

Product

Resources

About