Coronary Heart Disease in the Middle East and North Africa: Current Status and Future Goals

Traina, Mahmoud; Almahmeed, Wael; Edris, Ahmad; Tuzcu, E. Murat

doi:10.1007/s11883-017-0659-9

Cited by 45 publications

(45 citation statements)

References 50 publications

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“…However, the results in AMI were inconsistent with UAP, and we speculated that there might be 3 reasons: first, high smoking rate in patients with AMI, which is a high risk factor for AMI. [ 31 , 32 ] In this study, the percentage of smokers in AMI is much higher than that of UAP and CTR. Second, CAD is a slow developing disease under the combined action of many factors, involving a variety of pathological processes, and the expression level of a single gene may be changed by other pathological factors.…”

Section: Discussionmentioning

confidence: 56%

Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease

Zhang¹,

Huang

Yang

et al. 2017

Medicine

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Background:Coronary atherosclerotic heart disease (CAD) is mainly caused by atherosclerosis, an inflammatory disease characterized by plaque formation in arteries. Reactive oxygen species caused structural damage and dysfunction of arterial endothelial cells. Thioredoxin-interacting protein (TXNIP) is the endogenous inhibitor and regulator of thioredoxin, a major cellular antioxidant and antiapoptotic system. In order to explore the role of TXNIP in the occurrence and development of CAD, we detected the TXNIP expression and discussed its molecular mechanisms in CAD.Methods:The mRNA levels of TXNIP gene in peripheral leucocytes were detected in CAD and healthy controls (CTR) by quantitative real-time polymerase chain reaction. And TXNIP proteins were detected by western blotting.Results:TXNIP gene expression levels in patients with unstable angina pectoris (UAP, n = 96) were significantly increased compared with those of CTR (n = 192, P < .05). However, the situation is different in acute myocardial infarction (n = 96, P > .05). Logistic regression analysis showed that TXNIP levels were significantly positive correlated with UAP (OR = 1.728, P < .05).Conclusions:TXNIP gene expression in the peripheral leucocytes was increased in patients with UAP, indicating that TXNIP in circulating leucocytes may be involved in the pathogenesis of UAP.

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Section: Discussionmentioning

confidence: 56%

Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease

Zhang¹,

Huang

Yang

et al. 2017

Medicine

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“…The mean age for developing CAD in the Middle East is 10 years younger than the mean age of their western counterparts [2][3][4][5][6][7][8]. The prevalence of CAD risk factors among Saudi patients with established CAD is alarming; however, many of these are modifiable risk factors [9][10][11]. In Saudi Arabia, despite the widespread availability of hospitals with a catheterization laboratory, there are fewer patients treated with a primary percutaneous intervention [12].…”

Section: Introductionmentioning

confidence: 99%

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Albugami¹,

Al-Husayni²,

Bakhsh³

et al. 2020

Cureus

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ObjectiveCoronary artery disease (CAD) constitutes a significant health hazard in middle-aged individuals in Saudi Arabia. We sought to assess the level of knowledge of cardiovascular risk factors and describe the perception of coronary intervention among the general population in the city of Jeddah in the western part of Saudi Arabia. MethodsA cross-sectional study was conducted in the city of Jeddah during the period from April 2019 to September 1, 2019, by using a structured online questionnaire to assess the participants' awareness of risk factors for CAD and coronary intervention. The survey included questions about socio-demographic data, risk factors of cardiovascular diseases, symptoms of heart attack, knowledge of coronary catheterizations, as well as resources of knowledge about coronary heart disease.

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“…The Global Burden of Disease (GBD) study released that cardiovascular diseases (CVDs) as one of the most prominent noncommunicable diseases (NCD) was the leading global cause of death since 1980 and a leading cause of disease burden in the Eastern Mediterranean Region [1]. CVDs are predisposed by various risk factors such as increased low-density lipoprotein cholesterol (LDL-C), decreased high-density lipoprotein cholesterol (HDL-C), high blood triglyceride concentrations (TG), high blood pressure (BP), hyperglycemia, high body mass index (BMI), abdominal obesity and high in ammatory state [1][2][3][4]. When the impairment coincides with risk factors, it leads to a dramatic increase in the incidence of CVDs and associated morbidity and mortality [5,6].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Association Between an Overall Diet Quality Index and Latent Profiles of Cardiovascular Risk Factors: Results From a Population Based 13-year Follow Up Cohort Study

Nouri

Sadeghi

Mohammadifard

et al. 2020

Preprint

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Background: Cardiovascular diseases (CVDs) have been associated with an unhealthy lifestyle, including poor diet. Indices reflecting the overall quality of diets are more effective than single food or nutrient-based approaches are in clarifying the diet disease relationship. The present study aims to use latent variable modeling to examine the longitudinal joint relationships between the latent profiles of CVDs risk factors and the diet quality index (DQI).Methods: A total of 4390 Iranian adults aged 35 and older within the framework of the Isfahan Cohort Study (ICS) were included in the current secondary analysis. DQI was assessed using a validated food frequency questionnaire. Blood pressure (BP), anthropometric measurements, blood glucose, serum lipids, and high-sensitivity C-Reactive Protein (hs-CRP) were measured according to standard protocols in 2001, 2007, and 2013 to evaluate the profiles of CVDs risk factors. A Bayesian multidimensional Graded Responses Linear Mixed Model was used for data analysis. Results: At baseline, the participants’ mean (SD) age was 50.09(11.21), and 49.5% of them were male. Three latent profiles of CVDs risk factors were derived: (i) Fit Pre-Metabolic Syndrome (FPMS) profile characterized by normal anthropometric indices and some impaired metabolic risk factors; (ii) DysLipoproteinemia Central Obese (DLCO) profile with abdominal obesity and impaired low-density lipoprotein cholesterol as well as other normal risk factors; (iii) Impaired Laboratory Inflammatory State (ILIS) profile with impaired high-density lipoprotein cholesterol and hs-CRP and other normal risk factors. In general, higher scores of the extracted latent profiles indicated more impaired function in the related risk factors. After controlling for various potential fixed and time-varying confounding variables, a significant positive longitudinal association was found between FPMS, DLCO, and ILIS profiles and DQI (β (95% CrI): 0.26 (0.03,0.51), 0.14 (0.01,0.27), and 0.24 (0.11,0.38), respectively), demonstrating that lower overall diet quality was associated with more impaired function of the related risk factors.Conclusions: Diet quality is associated with all emerging profiles of CVDs risk factors. Increasing the knowledge of the community about the importance of the quality of consumed foods may help to prevent CVDs. It is recommended that further investigations, particularly interventional studies, be conducted to confirm our results.

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Coronary Heart Disease in the Middle East and North Africa: Current Status and Future Goals

Cited by 45 publications

References 50 publications

Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease

Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease

Correction

Longitudinal Association Between an Overall Diet Quality Index and Latent Profiles of Cardiovascular Risk Factors: Results From a Population Based 13-year Follow Up Cohort Study

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