Coronary lipid-rich plaque characteristics in Japanese patients with acute coronary syndrome and stable angina: A near infrared spectroscopy and intravascular ultrasound study

Takahashi, Norihito; Endo, Hirohisa; Takeuchi, Mitsuhiro; Kato, Yoshiteru; Okai, Iwao; Iwata, Hiroshi; Okazaki, Shinya; Isoda, Kikuo; Miyauchi, Katsumi; Minamino, Tohru

doi:10.1016/j.ijcha.2021.100747

Cited by 8 publications

(11 citation statements)

References 29 publications

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“…LP-PLA2 is a key indicator in the study of clinical vascular disease and an independent risk factor for cardiovascular disease mostly used to study inflammatory response mediators [2]. e pathological basis of ACS in the elderly is the rupture of coronary atherosclerotic plaque, followed by complete or incomplete occlusive thrombosis [3].…”

Section: Discussionmentioning

confidence: 99%

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The Diagnostic Value of Combined Detection of Serum Lp-PLA2 and Hcy and Color Doppler in Elderly Patients with Acute Coronary Syndrome and Effect on Endothelial Function

Zhao

Luo

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To evaluate the application value of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) and homocysteine (Hcy) combined with color Doppler detection in elderly patients with acute coronary syndrome (ACS) and the influence on their endothelial function. Methods. From February 2019 to October 2020, 100 elderly patients with suspected ACS treated in our hospital were recruited and assigned (1 : 1) to a control group or an experimental group. The control group received color Doppler detection, and the experimental group received the combined detection of serum Lp-PLA2 and Hcy and color Doppler. Positive results were determined by the combined detection of the levels of LP-PLA2 and Hcy and color Doppler. The two groups were compared in terms of specificity, susceptibility, positive detection rate, negative detection rate, test accuracy, the area under the receiver operating characteristic (ROC) curve (AUC), the expression levels of interleukin-2 (IL-2), interleukin-12 (IL-12), interleukin-13 (IL-13), and the vascular endothelial function. The patients with ACS were divided into three subgroups according to the Gensini score three-quartile interval, and their Lp-PLA2 levels were calculated for analysis. Results. The test specificity, susceptibility, positive detection rate, negative detection rate, test accuracy, and AUC in the experimental group were much better than the those in the control group (all P < 0.05 ), and there were no significant differences in the expression levels of IL-2, IL-12, IL-13, and vascular endothelial function between the two groups ( P > 0.05 ). The three subgroups showed similar levels of fasting blood glucose, total cholesterol, triglyceride, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, apolipoprotein A-I, glutamic-pyruvic transaminase, lutamic-oxaloacetic transaminase, homocysteine, and amino-terminal pro-brain natriuretic peptide (all P > 0.05 ). The severe condition group had the highest Lp-PLA2 level, followed by the moderate group, and then the mild group ( P < 0.05 ). Moreover, the levels of LP-PLA2, aspartate transaminase (AST), and N-terminal pro hormone B-type natriuretic peptide (NT-proBNP) were all influencing factors for the coronary Gensini score (all P < 0.05 ). Conclusion. The combined detection of serum Lp-PLA2, Hcy, and color Doppler significantly improves the diagnostic accuracy, specificity, and susceptibility in the elderly with ACS, with little impact on their vascular endothelial function.

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Section: Discussionmentioning

confidence: 99%

“…Acute coronary syndrome (ACS) refers to a series of acute symptoms caused by changes in the position of plaques in the coronary arteries that a ect the ow of blood in the arteries. Such symptoms can cause acute myocardial ischemia, myocardial infarction, angina, and thrombus [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Value of Combined Detection of Serum Lp-PLA2 and Hcy and Color Doppler in Elderly Patients with Acute Coronary Syndrome and Effect on Endothelial Function

Zhao

Luo

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…We imaged five cylindrical phantom models made from an acrylic resin with known lumen diameters (1.51, 2.03, 3.04, 4.04, and 5.04 mm, respectively) using OFDI (catheter: FastView and console: LUNAWAVE, Terumo Corporation), FD-OCT (Dragonfly JP and ILUMIEN OPTIS, Abbott Vascular), and 6 mechanically rotating IVUS systems including the system 1) 40-MHz IVUS (ViewIT and VISICUBE, Terumo Corporation), 2) 40-MHz IVUS (OptiCross and iLab, Boston Scientific Corporation), 3) 45-MHz IVUS (Refinity and CORE Mobile, Philips Volcano), 4) 60-MHz IVUS (AltaView and VISICUBE, Terumo Corporation), 5) 60-MHz IVUS (OptiCross HD and iLab, Boston Scientific Corporation), and 6) broad-band frequency IVUS (DualPro and MAKOTO, Nipro) [3] , [4] , [5] , [6] , [7] , [8] . Each of the IVUS systems consist of a flexible monorail catheter with a mechanical rotational (1800 rpm) single transducer probe (annular array) at its tip that emits ultrasound waves in the 40–60 MHz range or broad band of frequencies and an electronics console to reconstruct the image [8] .…”

Section: Methodsmentioning

confidence: 99%

Head-to-head comparison of quantitative measurements between intravascular imaging systems: An in vitro phantom study

Nishi

Imura

Kitahara

et al. 2021

IJC Heart & Vasculature

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Introduction The present study aimed to compare the accuracy of quantitative measurements by contemporary intravascular imaging systems including optical frequency domain imaging (OFDI), frequency domain optical coherence tomography (FD-OCT), and 6 intravascular ultrasound (IVUS) systems. Methods We imaged five cylindrical phantom models made from an acrylic resin with known lumen diameters (1.51, 2.03, 3.04, 4.04, and 5.04 mm, respectively) using OFDI (FastView and LUNAWAVE, Terumo), FD-OCT (Dragonfly JP and ILUMIEN OPTIS, Abbott Vascular), and 6 mechanically rotating IVUS systems including a system, two 40-MHz, one 45-MHz, two 60-Mhz and one broad-band frequency IVUS systems. The OFDI, FD-OCT, and IVUS images were obtained using automated motorized pullback in a tank filled with 37-degree Celsius saline and, in cases of OFDI and FD-OCT, contrast-saline mixture (1:1 ratio) and contrast under the system setting of the refractive index for the corresponding flush medium. Results All the imaging systems showed good accuracy and excellent precision of lumen measurement with the relative differences between the measured diameter and actual phantom diameter being ranging from −2.9% to 8.0% and minimum standard deviations of the measured diameters (≤0.02 mm). Conclusion The present study demonstrated that contemporary intravascular imaging systems including OFDI, FD-OCT, and IVUS provided clinically acceptable accuracy and excellent precision of quantitative lumen measurement in phantom models in vitro across a wide range of dimensions. Future research to confirm these findings in vivo are warranted.

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“…The presence of increased CRP and high-risk features in OCT of patients hospitalized for an ACS may be an important prognostic clue for subsequent events [ 25 ]. However, other studies have found no association of CRP with lipid-rich plaques or with TCFAs [ 26 , 27 ], with the study of Koga et al additionally pointing towards the association of pentraxin-3, another marker indicative of inflammation, with TCFAs instead of CRP [ 27 ]. A recent study further confirmed this hypothesis, with post-PCI pentraxin-3 being inversely correlated with fibrous cap thickness and positively correlated with lipid core length [ 28 ].…”

Section: Non-invasive Assessment Of the Vulnerable Coronary Atheroscl...mentioning

confidence: 99%

Non-Invasive Modalities in the Assessment of Vulnerable Coronary Atherosclerotic Plaques

et al. 2022

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Coronary atherosclerosis is a complex, multistep process that may lead to critical complications upon progression, revolving around plaque disruption through either rupture or erosion. Several high-risk features are associated with plaque vulnerability and may add incremental prognostic information. Although invasive imaging modalities such as optical coherence tomography or intravascular ultrasound are considered to be the gold standard in the assessment of vulnerable coronary atherosclerotic plaques (VCAPs), contemporary evidence suggests a potential role for non-invasive methods in this context. Biomarkers associated with deleterious pathophysiologic pathways, including inflammation and extracellular matrix degradation, have been correlated with VCAP characteristics and adverse prognosis. However, coronary computed tomography (CT) angiography has been the most extensively investigated technique, significantly correlating with invasive method-derived VCAP features. The estimation of perivascular fat attenuation as well as radiomic-based approaches represent additional concepts that may add incremental information. Cardiac magnetic resonance imaging (MRI) has also been evaluated in clinical studies, with promising results through the various image sequences that have been tested. As far as nuclear cardiology is concerned, the implementation of positron emission tomography in the VCAP assessment currently faces several limitations with the myocardial uptake of the radiotracer in cases of fluorodeoxyglucose use, as well as with motion correction. Moreover, the search for the ideal radiotracer and the most adequate combination (CT or MRI) is still ongoing. With a look to the future, the possible combination of imaging and circulating inflammatory and extracellular matrix degradation biomarkers in diagnostic and prognostic algorithms may represent the essential next step for the assessment of high-risk individuals.

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Coronary lipid-rich plaque characteristics in Japanese patients with acute coronary syndrome and stable angina: A near infrared spectroscopy and intravascular ultrasound study

Cited by 8 publications

References 29 publications

The Diagnostic Value of Combined Detection of Serum Lp-PLA2 and Hcy and Color Doppler in Elderly Patients with Acute Coronary Syndrome and Effect on Endothelial Function

The Diagnostic Value of Combined Detection of Serum Lp-PLA2 and Hcy and Color Doppler in Elderly Patients with Acute Coronary Syndrome and Effect on Endothelial Function

Head-to-head comparison of quantitative measurements between intravascular imaging systems: An in vitro phantom study

Non-Invasive Modalities in the Assessment of Vulnerable Coronary Atherosclerotic Plaques

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