2015
DOI: 10.1007/s10554-015-0619-9
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Coronary microcirculation changes in non-ischemic dilated cardiomyopathy identified by novel perfusion CT

Abstract: Intramyocardial microvessels demonstrate functional changes in cardiomyopathies. However, clinical computed tomography (CT) does not have adequate spatial resolution to assess the microvessels. Our hypothesis is that these functional changes manifest as altered heterogeneity of the spatial distribution of arteriolar perfusion territories. Our goal was to determine whether the spatial analysis of perfusion CT could clinically detect changes in the function and structure of the intramyocardial microcirculation i… Show more

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Cited by 6 publications
(7 citation statements)
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“…Although Behrenbeck et al, 21,22 may have slightly different evidence at the moment regarding the value of IMBV quantification and its ability to represent microcirculatory health when compared to the method proposed by Mohy-ud-Din et al, they do agree that early changes in IMBV can be used to glean valuable information regarding microcirculatory function. With limited evidence to support either total IMBV versus spatial distribution of IMBV as an index of microcirculatory health, the best way to move forward is to focus on accumulating strong scientific evidence.…”
mentioning
confidence: 98%
See 1 more Smart Citation
“…Although Behrenbeck et al, 21,22 may have slightly different evidence at the moment regarding the value of IMBV quantification and its ability to represent microcirculatory health when compared to the method proposed by Mohy-ud-Din et al, they do agree that early changes in IMBV can be used to glean valuable information regarding microcirculatory function. With limited evidence to support either total IMBV versus spatial distribution of IMBV as an index of microcirculatory health, the best way to move forward is to focus on accumulating strong scientific evidence.…”
mentioning
confidence: 98%
“…The increased spatial heterogeneity is hypothesized to be an indication of microvascular dysfunction. A subsequent study published by the same group in 2015, 22 using the same techniques evaluated early changes in myocardial microcirculation in patients with and without dilated cardiomyopathy (n = 24 per group). Similar to the results from their 2014 study, there was no difference between the two groups in overall myocardial perfusion and IMBV, but there were significantly differences in spatial heterogeneity across sub-ROI regions in the myocardium between patients with and without dilated cardiomyopathy.…”
mentioning
confidence: 99%
“…Although we cannot dismiss the possibility that a diffuse disease could have played a role in this phenomenon, especially considering that we did not perform any intravascular imaging, the lack of any angiographic disease could be quite reassuring about the possibility that this phenomenon could be related to a pathophysiological mechanism instead of a technical pitfall of FFR . We may hypothesize that this could be related to LV dilatation and possibly to increased LV mass that is not adequately supported by a coronary system intrinsically undersized. This is indirectly confirmed by the evidence of a significantly lower body surface area (with non‐significantly higher LV dimensions), but further confirmations are clearly on demand.…”
Section: Baseline Characteristicsmentioning
confidence: 91%
“…Miller et al [66] examined heterogeneity of the spatial distribution of arteriolar perfusion territories as a correlate of intra-myocardial microvessels density and distribution. in patient with dilated cardiomyopathy (DCM) and a control group segmental myocardial perfusion (F) and intra-myocardial blood volume (Bv) were computed.…”
Section: Temporal Resolution Matters!mentioning
confidence: 99%