Coronary plaque composition influences biomechanical stress and predicts plaque rupture in a morpho-mechanic OCT analysis

Milzi, Andrea; Lemma, Enrico Domenico; Dettori, Rosalia; Burgmaier, Kathrin; Reith, Sebastian; Burgmaier, Mathias

doi:10.7554/elife.64020

Cited by 22 publications

(22 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Optical coherence tomography (OCT) provides detailed images of the fibrous cap using near infrared light delivered via a fiber optic wire. The images provided by OCT correlate well with histological features high signals in the fibrous cap signify macrophage adherence and thrombus formation [ 28 , 29 ]. Near infrared spectroscopy (NIRS) is another catheter-based invasive technique.…”

Section: Imaging Biomarkers Of Vulnerable Plaquesmentioning

confidence: 97%

Vulnerable Atherosclerotic Plaque: Is There a Molecular Signature?

Chiorescu

Mocan

Buda³

et al. 2022

IJMS

View full text Add to dashboard Cite

Atherosclerosis and its clinical manifestations, coronary and cerebral artery diseases, are the most common cause of death worldwide. The main pathophysiological mechanism for these complications is the rupture of vulnerable atherosclerotic plaques and subsequent thrombosis. Pathological studies of the vulnerable lesions showed that more frequently, plaques rich in lipids and with a high level of inflammation, responsible for mild or moderate stenosis, are more prone to rupture, leading to acute events. Identifying the vulnerable plaques helps to stratify patients at risk of developing acute vascular events. Traditional imaging methods based on plaque appearance and size are not reliable in prediction the risk of rupture. Intravascular imaging is a novel technique able to identify vulnerable lesions, but it is invasive and an operator-dependent technique. This review aims to summarize the current data from literature regarding the main biomarkers involved in the attempt to diagnose vulnerable atherosclerotic lesions. These biomarkers could be the base for risk stratification and development of the new therapeutic drugs in the treatment of patients with vulnerable atherosclerotic plaques.

show abstract

Section: Imaging Biomarkers Of Vulnerable Plaquesmentioning

confidence: 97%

Vulnerable Atherosclerotic Plaque: Is There a Molecular Signature?

Chiorescu

Mocan

Buda³

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…2A ). The thickness of the fragile cap, which is widely accepted and recognized in clinical practice, is 65 µm ( 17 ). TCFA, in the context of OCT, is defined as a lipid-rich plaque with a thin fibrous cap (the thinnest part is ≤65 µm), and the lipid component in a plaque occupies ≥2 quadrants ( 17 ).…”

Section: Oct Evaluation Of Atherosclerotic Plaque-related Factorsmentioning

confidence: 99%

“…The thickness of the fragile cap, which is widely accepted and recognized in clinical practice, is 65 µm ( 17 ). TCFA, in the context of OCT, is defined as a lipid-rich plaque with a thin fibrous cap (the thinnest part is ≤65 µm), and the lipid component in a plaque occupies ≥2 quadrants ( 17 ). A previous study performed a histomorphological analysis of 295 coronary plaques (105 fibrous plaques, 88 TCFAs and 102 ruptured plaques) in patients who suffered sudden cardiac death.…”

Section: Oct Evaluation Of Atherosclerotic Plaque-related Factorsmentioning

confidence: 99%

Advantages and prospects of optical coherence tomography in interventional therapy of coronary heart disease (Review)

Wang

Yuan

et al. 2022

Exp Ther Med

View full text Add to dashboard Cite

Coronary heart disease is the leading cause of mortality among all diseases globally. Percutaneous coronary intervention (PCI) is a key method for the treatment of coronary heart disease. Optical coherence tomography (OCT) is an optical diagnostic technology with a resolution of up to 10 µm, which is able to accurately assess the composition of the coronary arterial wall and determine the characteristics of atherosclerotic lesions. It is also highly consistent with pathological examinations, optimizing the effect of stent implantation and evaluation of the long-term effectiveness and safety of the stent, which has irreplaceable value in the field of precision and optimization of coronary intervention. The innovative OCT technology may help provide more comprehensive clinical research evidence. The application of OCT in clinical and basic research of coronary atherosclerosis, selection of treatment strategies for acute coronary syndromes, optimization of interventional treatment efficacy, evaluation of novel stents, intimal stent coverage and selection of dual antiplatelet drugs has become more widely used, affecting the current coronary interventional treatment strategies to a certain extent. The aim of the present review was to discuss the role of OCT in evaluating preoperative plaque characteristics, guiding PCI and evaluating the effects of postoperative stents or drug treatments.

show abstract

“…Mechanical deformations in the present study are not large, because studies have shown that the maximum displacement is less than 10% of the original artery dimensions. Hence, the linear elastic assumption is appropriate for the artery wall [ 30 , 31 ]. Based on the previous studies [ 9 , 17 ], time steps of 0.001 s, 0.005 s, and 0.01 s were used.…”

Section: Boundary Conditions and Numerical Techniquesmentioning

confidence: 99%

Investigation of Artery Wall Elasticity Effect on the Prediction of Atherosclerosis by Hemodynamic Factors

Kalbasi

Sharifzadeh

Jahangiri

2022

Applied Bionics and Biomechanics

View full text Add to dashboard Cite

Atherosclerosis is a vascular disease in which some parts of the artery undergo stenosis due to the aggregation of fat. The causes and location of stenosis can be determined using fluid mechanics and parameters such as pressure, effective wall shear stress, and oscillatory shear index (OSI). The present study, for the first time, numerically investigates the pulsatile blood flow inside arteries with elastic and rigid walls in simple and double stenosis (80% stenosis) by using k -ω model and physiological pulse. The reason for applying the k -ω model in the present study was to provide more consistent results with clinical results to improve the accuracy in estimating atherosclerosis disease. The investigation of the time-mean wall shear stress indicated that for double stenosis, the difference between the results of the rigid and elastic artery assumptions is greater than the case of simple stenosis, so that this difference percent can be up to 2.5 times. In addition, the results showed that the pressure drop for the first stenosis is greater than the second stenosis, by 810 Pa (for solid artery) and 540 Pa (for elastic artery). The results also revealed that for simple stenosis, the length of the diseases prone zone in the elastic artery is 21% longer than the rigid one which this figure for double stenosis is calculated to be about 40%. Comparing the results of the simple stenosis with double, one affirmed that the artery wall thickness growth for case of double stenosis is greater than that of the single one.

show abstract

Coronary plaque composition influences biomechanical stress and predicts plaque rupture in a morpho-mechanic OCT analysis

Cited by 22 publications

References 32 publications

Vulnerable Atherosclerotic Plaque: Is There a Molecular Signature?

Vulnerable Atherosclerotic Plaque: Is There a Molecular Signature?

Advantages and prospects of optical coherence tomography in interventional therapy of coronary heart disease (Review)

Investigation of Artery Wall Elasticity Effect on the Prediction of Atherosclerosis by Hemodynamic Factors

Contact Info

Product

Resources

About