Coronary Revascularisation in Chronic Kidney Disease Part 1: Stable Coronary Artery Disease

Seddon, Mike; Curzen, Nick

doi:10.1111/j.1755-6686.2010.00156.x

Cited by 6 publications

(3 citation statements)

References 103 publications

(92 reference statements)

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“…While considering revascularization, one should consider two aspects: the application rate of optimal medical therapy and the efficacy and risks of revascularization [80]. …”

Section: Treatment Strategies For Cad In Ckdmentioning

confidence: 99%

An Update on Coronary Artery Disease and Chronic Kidney Disease

Afsar

Türkmen

Covic

et al. 2014

International Journal of Nephrology

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Despite the improvements in diagnostic tools and medical applications, cardiovascular diseases (CVD), especially coronary artery disease (CAD), remain the most common cause of morbidity and mortality in patients with chronic kidney disease (CKD). The main factors for the heightened risk in this population, beside advanced age and a high proportion of diabetes and hypertension, are malnutrition, chronic inflammation, accelerated atherosclerosis, endothelial dysfunction, coronary artery calcification, left ventricular structural and functional abnormalities, and bone mineral disorders. Chronic kidney disease is now recognized as an independent risk factor for CAD. In community-based studies, decreased glomerular filtration rate (GFR) and proteinuria were both found to be independently associated with CAD. This paper will discuss classical and recent epidemiologic, pathophysiologic, and clinical aspects of CAD in CKD patients.

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“…While considering revascularization, one should consider two aspects: the application rate of optimal medical therapy and the efficacy and risks of revascularization [80]. …”

Section: Treatment Strategies For Cad In Ckdmentioning

confidence: 99%

An Update on Coronary Artery Disease and Chronic Kidney Disease

Afsar

Türkmen

Covic

et al. 2014

International Journal of Nephrology

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show abstract

“…Patients at high risk for developing CKD can be identified early, and potential modifications in therapy can prevent worsening of kidney function and progression toward disease. Kidney disease progression is associated with significant morbidity and mortality 5 – 7 . Patients with kidney disease often suffer from anemia, malnutrition, bone disease, neuropathy, calcium and phosphorous imbalances, and cardiovascular disease.…”

Section: Definition Of Ckd Stages 1 To 5 According To the Kdoqi 2002 mentioning

confidence: 99%

The Old and New Methods of Assessing Kidney Function

Steffl

Bennett

Olyaei

2012

The Journal of Clinical Pharma

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Chronic kidney disease is a worldwide problem. Accurate assessment of kidney function is important for defining stages of kidney disease and assisting with drug dosing. Glomerular filtration rate (GFR) is a good index of the health of the kidney. Although measured GFR using an exogenous substance is the most accurate, it is difficult to obtain due to cost and resources. Equations calculating creatinine clearance and estimated GFR as a measure of kidney function have been developed using serum creatinine as a marker of kidney function. The Cockcroft-Gault, Modification of Diet in Renal Disease, and Chronic Kidney Disease Epidemiology Collaboration equations have been shown to have statistically significant differences in estimating GFR in various populations. Drug-dosing adjustments based on the various equations may differ. However, without clinical outcome data, it is yet to be determined whether these differences are clinically significant.

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“…It concluded that medical management promotes adequate long‐term survival, although failure to revascularise if indicated is associated with an increased risk of cardiovascular events and mortality (note this was not randomised and is likely to be influenced by selection bias) (De Lima et al 2010). Patients with severe CKD have significantly higher procedural and medium‐term complication rates than those seen in patients with a normal renal function (Seddon & Curzen 2010). Screening all asymptomatic ESRF patients would inevitably find stenoses, leading to prophylactic intervention (which might be inappropriate), causing unnecessary complications.…”

Section: Coronary Revascularisationmentioning

confidence: 99%