Coronary risk prediction by the correlation of total cholesterol/high-density lipoprotein, triglyceride/high-density lipoprotein, low-density lipoprotein/high-density lipoprotein ratios, non-high-density lipoprotein, apolipoprotein-B, and high-sensitivity C-reactive protein with low-density lipoprotein in Indian patients under statin therapy

Badrinath, AK; Nagarajan, Krishnan; Anand, Piyush; Babu, Shifas; Asmathulla, S; Hassan, Mahmoud M.

doi:10.4103/heartindia.heartindia_2_19

Cited by 3 publications

(2 citation statements)

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“…According to Sibel et al, LDL-C/HDL-C and TC/HDL-C were more signi cant than considering HDL-C,LDL-C and TC separately,TC/HDL-C,LDL-C/HDL-C ratios had been examined be atherogenic risk factors in coronary heart disease.In recent study, the LDL-C/HDL-C and TC/HDL-C ratios played signi cant roles in the lipid panel in ischemic patients which were new atherogenic indexes than TC,LDL-C, and HDL-C parameters [21][22] . T Sun et al compared patients and healthy controls, the LDL-C/HDL-C ratio was higher in patients with CAD (2.94 ± 1.06 vs. 2.36 ± 0.78, p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

TC/(HDL-C+TBIL) and LDL-C/(HDL-C+TBIL) ratios predict early neurological deterioration in minor ischemic stroke：A retrospective study

Lu,

Wang,

et al. 2023

Preprint

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Objective It is generally known that bilirubin and cholesterol can significantly affect the clinical outcome of minor ischemic stroke(MIS) .In other words,early neurological deterioration (END) is still difficult to be predicted which is usually occurs in MIS patients .Our aim was to study the correlation between END,total bilirubin and cholesterol( total cholesterol,TC, low density lipoprotein cholesterol,LDL-C,high density lipoprotein cholesterol,HDL-C) by TC/(HDL-C+TBIL) and LDL-C/(HDL-C+TBIL) ratios. Methods This was a retrospective study.MIS Patients within 48 hours of onset were retrospective recruited from Baoding NO.1 Central Hospital. END was defined as an NIHSS score increased≥ 2 points or individual score of consciousness level and muscle strength increased ≥1 point or new neurological damage manifestations during the 72 hours.During the period,total cholesterol, low density lipoprotein cholesterol,high density lipoprotein cholesterol and total bilirubin , TC/(HDL-C+TBIL) and (LDL-C/(HDL-C+TBIL) ratios were calculated. Results 149 patients were included, 39 cases(26.17%) had END(END group) and 110 cases(73.83%) did not had END(non-END group). In patients with non-END, smoking , TBIL were significantly higher than END(P＜0.05)，but systolic pressure, neutrophil ratio, fasting glucose,LDL-C/(HDL-C+TBIL), TC/(HDL-C+TBIL) were lower(P＜0.05). In tne logistic regression analysis LDL-C/( HDL-C+TBIL) (OR=1.061, 95%CI:1.013~1.111, P=0.012), TC/(HDL-C+TBIL) (OR=1.048, 95%CI:1.008~1.091, P=0.019) were independent risk factors for END. The receiver operated curve (ROC) showed that LDL-C/(HDL-C+TBIL) predicted END with sensitivity 53.8%, specificity 87.3% , TC/(HDL-C+TBIL) predicted END with sensitivity 64.1%, specificity 79.1% . Conclusion END occurs 26.17% in minor ischemic stroke. TC/(HDL-C+TBIL) and (LDL-C/(HDL-C+TBIL) ratios were statistically significant predictor for END in MIS.

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Section: Discussionmentioning

confidence: 99%

TC/(HDL-C+TBIL) and LDL-C/(HDL-C+TBIL) ratios predict early neurological deterioration in minor ischemic stroke：A retrospective study

Lu,

Wang,

et al. 2023

Preprint

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“… Yaseen RI, 2021 14 Not mentioned Cross-sectional study Coronary heart disease To measure apo B/apo A-1 ratio in patients with ACS and assess its relationship with the severity of CAD NA 90 Apo B/Apo A1 ratio highly significant in patients with ACS and ApoB found to be independent risk predictor for CAD severity. Badrinath AK, 2021 15 India Cross-sectional study Coronary heart disease To study non-HDL, apo-B, TC/HDL, TG/HDL, LDL/HDL ratios, and hs-CRP in patients under statin therapy; and to correlate them with their LDL; and to identify which biomarker is better at detecting CHD risk. NA 87 Non-HDL or TC/HDL or LDL/HDL ratios were found be better biomarkers for future CHD risk prediction.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein B - An ideal biomarker for atherosclerosis?

Singh,

Prabhakaran

2024

Indian Heart Journal

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Addiction habits in a rural cohort of injection drug users and effects on serum lipid profile: Analysis of a repeated measures study from an eastern state of India

LAHIRI,

JHA,

CHAKRABORTY

2024

NMJI

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Background Injecting drug use (IDU) is associated with several cardiometabolic risks. We aimed to measure the independent effects of IDU behaviour and related factors on serum lipid profile among people who inject drugs (PWIDs). Methods We did a longitudinal study with six follow-up measurements at an interval of 2 months among 104 PWIDs from 11 selected hotspots under two blocks in West Bengal, India. Generalized estimating equations with robust standard errors analysed the effect of addiction habits on lipid profile parameters. Results The mean (SD) age of the participants was 27.6 (5.24) years, 36.5% married and 44.3% were unemployed at the time of recruitment. At the baseline, the mean (SD) body mass index (BMI) and fasting blood sugar (FBS) were 20.0 (1.82) kg/m2 and 112.0 (15.90) mg/dl, respectively. The mean duration of drug use was 2.5 (1.20) years. While 62.5% had normal triglyceride (TG), 14.4% had high total cholesterol (TC) and 69.2% had dyslipidaemia at the baseline. Adjusted for age, BMI, FBS and other addiction-related variables, models showed that longer duration of drug use (>3 years) resulted in higher levels of TG, higher TC-to-high-density lipoprotein ratio and dyslipidaemia. Tobacco use and high FBS level were also risk factors for dyslipidaemia. Conclusions Higher duration of IDU, tobacco use and higher FBS were associated with deranged lipid profile among PWIDs.

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Cited by 3 publications

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TC/(HDL-C+TBIL) and LDL-C/(HDL-C+TBIL) ratios predict early neurological deterioration in minor ischemic stroke：A retrospective study

TC/(HDL-C+TBIL) and LDL-C/(HDL-C+TBIL) ratios predict early neurological deterioration in minor ischemic stroke：A retrospective study

Apolipoprotein B - An ideal biomarker for atherosclerosis?

Addiction habits in a rural cohort of injection drug users and effects on serum lipid profile: Analysis of a repeated measures study from an eastern state of India

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