Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo

Díaz-Rodríguez, Sergio; Charlotte, Rasser; Mesnier, Jules; Chevallier, Pascale; Gallet, Romain; Choqueux, Christine; Even, Guillaume; Chaubet, Frédéric; Nicoletti, Antonino; Ghaleh, Bijan; Feldman, Laurent J.; Diego, Mantovani; Caligiuri, Giuseppina

doi:10.1093/eurheartj/ehab027

Cited by 43 publications

(26 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another solution is the use of a CD31-mimetic peptide to favor vascular homeostasis and arterial wall healing. Such a surface functionalization has been proven to be successful: one week after implantation, CD31-mimetic struts were reportedly fully endothelialized with no activated platelets/leukocytes, while four weeks after stenting a significant reduction in neointima development was noticed compared to bare-metal stents [ 177 ].…”

Section: Stent Optimizationmentioning

confidence: 99%

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

et al. 2021

View full text Add to dashboard Cite

One of the leading causes of morbidity and mortality worldwide is coronary artery disease, a condition characterized by the narrowing of the artery due to plaque deposits. The standard of care for treating this disease is the introduction of a stent at the lesion site. This life-saving tubular device ensures vessel support, keeping the blood-flow path open so that the cardiac muscle receives its vital nutrients and oxygen supply. Several generations of stents have been iteratively developed towards improving patient outcomes and diminishing adverse side effects following the implanting procedure. Moving from bare-metal stents to drug-eluting stents, and recently reaching bioresorbable stents, this research field is under continuous development. To keep up with how stent technology has advanced in the past few decades, this paper reviews the evolution of these devices, focusing on how they can be further optimized towards creating an ideal vascular scaffold.

show abstract

Section: Stent Optimizationmentioning

confidence: 99%

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

et al. 2021

View full text Add to dashboard Cite

show abstract

“…[ 42 ] ECs adhesion, [ 43 ] proliferation, [ 44 ] and migration [ 45 ] are the initial steps essential for the eventual buildup of an entire endothelial layer. [ 46 ] HA can bind to CD44 which is highly expressed on ECs and promotes ECs growth. [ 47 ] Furthermore, high molecular weight HA inhibits the mitogen‐dependent induction of cyclin D1 reducing the proliferation of vascular smooth muscle cells and fibroblasts.…”

Section: Resultsmentioning

confidence: 99%

Double‐Network Hydrogel Armored Decellularized Porcine Pericardium as Durable Bioprosthetic Heart Valves

Cheng

Liu

Qian

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Heart valves have extraordinary fatigue resistance which beat ≈3 billion times in a lifetime. Bioprosthetic heart valves (BHVs) made from fixed heteroplasm that are incrementally used in heart valve replacement fail to sustain the expected durability due to thrombosis, poor endothelialization, inflammation, calcification, and especially mechanical damage induced biocompatibility change. No effective strategy has been reported to conserve the biological properties of BHV after long-term fatigue test. Here, a double-network tough hydrogel is introduced, which interpenetrate and anchor into the matrix of decellularized porcine pericardium (dCell-PP) to form robust and stable conformal coatings and reduce immunogenicity. The ionic crosslinked hyaluronic acid (HA) network mimics the glycocalyx on endothelium which improves antithrombosis and accelerates endothelialization; the chemical crosslinked hydrophilic polyacrylamide (PAAm) network further enhances antifouling properties and strengthens the shielding hydrogels and their interaction with dCell-PP. In vitro and rabbit ex vivo shunt assay demonstrate great hemocompatibility of polyacrylamide/HA hydrogel hybrid PP (P/H-PP). Cell experiments and rat subcutaneous implantation confirm satisfactory endothelialization, biocompatibility, and anticalcification properties. For hydrodynamic experiment, P/H-PP gains full mark at different flow conditions and sustains excellent biomechanical and biological properties after 200 000 000 cycles. P/H double-network hydrogel armoring dCell-PP is a promising progress to extend BHV durability for clinical implantation therapy.

show abstract

“…S. DiazRodriguez и соавт. показа ли, что страты СЛП через 7 дней после имплантации покрыты неструктурированной тканью, состоящей из фибрина, лейкоцитов и макрофагов [32]. Предполага ем, именно этот комплекс участвует в формировании неоинтимы.…”

Section: Discussionunclassified

Comparison of neointimal healing with bioresorbable scaffolds and drug-eluting stents in patients with stable ischaemic heart disease

Sapoznikov¹,

Galeeva²,

Бессонов³

et al. 2021

PKiK

View full text Add to dashboard Cite

Aim. To examine the process of neointimal formation after bioresorbable scaffolds (BRS) implantation using optical coherence tomography (OCT) in patients with stable coronary artery disease (SCAD) and to determine relationship between neointimal healing and biochemical parameters of inflammation. Methods. Patients with SCAD (n = 20) who were indicated for percutaneous coronary intervention (PCI) were enrolled. Patients were randomised into two groups as per the stent type. The treatment group comprised 10 patients who were implanted with BRS ABSORB (Abbott Laboratories, Abbott Park, USA) during PCI. The comparison group comprised 10 patients who were implanted with DES XIENCE (Abbott Laboratories, Abbott Park, USA) during PCI. All the patients underwent OCT imaging during PCI. Subsequently, 18 patients were subjected to coronary angiography with OCT imaging in 12 mon. The primary endpoint was the 12-month neointimal healing (NIH) score. Secondary endpoints were clinical outcomes (all-cause hospitalisation, myocardial infarction, probable stent thrombosis and death), OCT parameters at the 12-month follow-up and biochemical markers dynamics. Results. Initial angiographic data analysis indicated a higher rate of balloon pre-dilatation (100% vs. 30%; р = 0,003) and post-dilatation (100% vs. 20% р = 0,001) in patients of the treatment group. According to OCT, the NIH score was significantly higher in the XIENCE group [0 versus 9,14 (1,63–17,55); р = 0,008] at 12 mon. There was no significant difference in the clinical outcomes between the two groups. However, the ABSORB group had an increased CD40 level after 4–5 d of PCI. In agreement with the results of correlation analysis, there was an inverse correlation between the NIH score and CD40 level at 4–5 d after PCI (r = −0,576; р = 0,016). The cut-off value of CD40 level at 4–5 d after PCI was 47,5 ng/mL for the detection of optimal neointimal healing. Conclusion. In patients with SCAD, BRS demonstrated higher rate of neointimal healing than everolimus-coated stents. There was a registered inverse correlation of the NIH score with the CD40 level at 4–5 days after PCI. CD40 level > 47,5 ng/mL at 4–5 d after PCI increases the likelihood of optimal neointimal healing as per OCT data.Received 19 February 2021. Revised 7 June 2021. Accepted 16 June 2021.Funding: The study did not have sponsorship.Conflict of interest: The authors declare no conflicts of interests.Contribution of the authors Conception and study design: I.S. Bessonov, N.A. Musikhina, T.I. Petelina Data collection and analysis: S.S. Sapoznikov, I.S. Bessonov, N.А. Galeeva, A.O. Dyakova Statistical analysis: S.S. Sapoznikov, E.A. Gorbatenko Drafting the article: S.S. Sapoznikov, N.А. Galeeva, A.O. Dyakova Critical revision of the article: I.S. Bessonov, S.S. Sapoznikov, E.A. Gorbatenko, N.A. Musikhina Final approval of the version to be published: S.S. Sapoznikov, N.А. Galeeva, I.S. Bessonov, N.A. Musikhina, T.I. Petelina, A.O. Dyakova, E.A. Gorbatenko

show abstract

Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo

Cited by 43 publications

References 31 publications

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

Cardiovascular Stents: A Review of Past, Current, and Emerging Devices

Double‐Network Hydrogel Armored Decellularized Porcine Pericardium as Durable Bioprosthetic Heart Valves

Comparison of neointimal healing with bioresorbable scaffolds and drug-eluting stents in patients with stable ischaemic heart disease

Contact Info

Product

Resources

About