Coronary vascular and myocardial responses to carotid body stimulation in the dog

Abstract

Coronary vascular and myocardial responses to selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation were investigated in constantly ventilated, pentobarbital or urethan-chloralose anesthetized dogs. Bilaterally isolated carotid chemoreceptors were perfused with autologous blood of varying O2 and CO2 tensions via an extracorporeal lung circuit. Systemic gas tensions were unchanged. Effects of carotid chemoreceptor stimulation on coronary vascular resistance, left ventricular dP/dt, and strain-gauge arch output were studied at natural coronary blood flow with the chest closed and during constant-flow perfusion of the left common coronary artery with the chest open. Carotid chemoreceptor stimulation slightly increased left ventricular dP/dt and slightly decreased the strain-gauge arch output, while markedly increasing systemic pressure. Coronary blood flow increased; however, coronary vascular resistance wa.as not affected. These studies show that local carotid body stimulation increases coronary blood flow but has little effect on the myocardium. The increase in coronary blood flow results mainly from an increase in systemic arterial pressure. Thus these data provide little evidence for increased sympathetic activity of the heart during local stimulation of the carotid chemoreceptors with hypoxic and hypercapnic blood.

Unveiling the interaction profile of rosmarinic acid and its bioactive substructures with serum albumin

“…The STD AMP factors showed that the molecular structure of each ligand affects the epitope mapping of each proton. Their preference for Sudlow site I as it was derived from the competitive STD NMR experiments confirms the existing literature data 46,49,59 .…”

“…Herein, we used this method for mapping of the interacting epitopes of each of the three ligands with BSA. To our knowledge, no STD NMR experiments have been reported for rosmarinic and salvianic acid 59 . The simultaneous evaluation of the interaction profile of rosmarinic acid and its constituents could provide a global view on the driving forces that each component contributes to the final interaction on the integral compound.…”

<p>Analgesic Effect of Ultrasound-Guided Preoperative Unilateral Lateral Quadratus Lumborum Block for Laparoscopic Nephrectomy: A Randomized, Double-Blinded, Controlled Trial</p>

“…23 The stimulation of these receptors could lead to pain and autonomic changes. 24 Accordingly, the blockage of these receptors by local anesthetics could provide somatic and visceral analgesic effects. 20,23 There is no consensus on the volume and concentration of local anesthetics used in the QLB.…”

Control of the Myocardial Contractile State by Carotid Chemo- and Baroreceptor and Pulmonary Inflation Reflexes in Conscious Dogs

“…Finally, Ehrhart et al (10) found a slight increase in left ventricular (LV)l dPldt and slight decrease in LV contractile force, whereas Stern and Rapaport (11) indicated that the aortic chemoreceptor reflex induced positive inotropic effects but the carotid chemoreceptor reflex induced no inotropic effect. It must be pointed out that all of these studies (5)(6)(7)(8)(9)(10)(11) have been performed in anesthetized animal preparations, where the unknown mitigating effects of the anesthetic and general surgery play an undetermined role in the interpretation of these data.…”