Coronary vascular volume remodelling in rainbow trout<i>Oncorhynchus mykiss</i>

Simonot, D. L.; Farrell, Anthony P.

doi:10.1111/j.1095-8649.2009.02427.x

Cited by 11 publications

(5 citation statements)

References 47 publications

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“…a,b) induced by aplasia of the septum transversum . For instance, fish experiencing anaemia display increased heart mass most likely as a result of increased cardiac workload (Simonot & Farrell , ; Powell, Burke & Dahle , ). Reduced cardiac performance likely explains high mortality rates in stressed fish with heart deformities including hypoplastic or aplastic septum transversum (Brocklebank & Raverty ), demonstrating the potential severity of malformed septum transversum .…”

Section: Discussionmentioning

confidence: 99%

The effect of ploidy and incubation temperature on survival and the prevalence of aplasia of the septum transversum in Atlantic salmon, Salmo salar L

Fraser

Fleming

Poppe

et al. 2013

Journal of Fish Diseases

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Heart deformities are a concern in aquaculture and are linked to egg incubation temperature. Diploid and triploid Atlantic salmon, Salmo salar L., were incubated at 6, 8 and 10 °C and analysed for aplasia of the septum transversum (n = 150 ploidy⁻¹ incubation temperature⁻¹). Heart morphology (size and shape) was assessed in fish incubated at 6 °C and in fish with and without aplasia of the septum transversum (n = 9 group⁻¹) incubated at 10 °C. Egg mortality was significantly higher in triploids than in diploids at all incubation temperatures, and increased egg incubation temperatures increased mortality in both ploidy. Triploids grew quicker than diploids after egg incubation at 10 °C, but not at 6 °C. Aplasia of the septum transversum occurred only in triploid fish after incubation at 6 °C and 8 °C (0.7% and 3.3%, respectively) and was significantly greater (P ≤ 0.05) in triploids after incubation at 10 °C compared with diploids (30% and 18%, respectively). Aplasia of the septum transversum significantly increased heart mass and resulted in a long flat ventricle compared with fish displaying a septum transversum. The results suggest triploid salmon should be incubated below 8 °C.

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Section: Discussionmentioning

confidence: 99%

The effect of ploidy and incubation temperature on survival and the prevalence of aplasia of the septum transversum in Atlantic salmon, Salmo salar L

Fraser

Fleming

Poppe

et al. 2013

Journal of Fish Diseases

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“…To compensate for this, hypoxia-inducible factor 1a (HIF-1a), among others (Terova et al 2008), serves to regulate erythropoietin transcription, which increases erythrocyte formation . Additionally, cardiac output will likely be increased as a result of increase in stroke volume and cardiac frequency (Simonot and Farrell 2009). This itself will lead to a structural remodelling of the heart reported (McClelland et al 2005;Farrell 2007, 2009).…”

Section: Introductionmentioning

confidence: 99%

Cardiac remodelling, blood chemistry, haematology and oxygen consumption of Atlantic cod, Gadus morhua L., induced by experimental haemolytic anaemia with phenylhydrazine

Powell¹,

Burke²,

Dahle³

2010

Fish Physiol Biochem

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Anaemia is a common pathology associated with many infectious and non-infectious diseases. The effects of haemolytic anaemia induced by i.p. injection of phenylhydrazine (PHZ) were studied in Atlantic cod. Phenylhydrazine injection (0.3 mg kg(-1)) in a DMSO and saline vehicle induced a reproducible and stable anaemia reducing haematocrit, (Hct) by 62% over 3 weeks. Controls consisted of fish injected with saline and DMSO/saline vehicle with minimal effects on Hct or whole blood haemoglobin (Hb). Although anaemia resulted in reduced blood lactate and glucose in PHZ injected fish, there were no effects of anaemia on blood, sodium, chloride or potassium. Similarly, there were no changes in the relative proportions of leucocytes in the blood although an increase in the number of immature erythrocytes was observed in the anaemic fish. Anaemic fish showed a 29 and 22% increase in cardiac somatic index (CSI) relative to saline and vehicle controls, respectively, although there were no significant differences in the linear dimensions of the ventricle. Changes in cardiac somatic and ventricular somatic index correlated positively and significantly with Hct but not with whole blood Hb concentration. Anaemic fish had significantly reduced resting routine oxygen consumption compared with vehicle controls but were not able to increase oxygen consumption following a bout of exhaustive exercise. Plasma lactate concentrations increased significantly after exercise to a greater extent in anaemic fish compared with vehicle control fish. Phenylhydrazine is a useful model for studying haemolytic anaemia in Atlantic cod with minimal effects on blood biochemistry and haematology and clearly reduces the aerobic capacity in Atlantic cod.

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“…Haemolytic anaemia is the result of haemolysis or reduced lifespan of circulating erythrocytes and commonly attributed to chemical intoxication that interferes with haemoglobin synthesis or elicits redox reactions resulting in erythrocytic damage (Beutler, 2005). Haemolytic anaemia has been induced using phenylhydrazine in a number of fish species (Cameron & Wolschlag, 1969; Jones, 1971; Smith et al , 1971; Simonot & Farrell, 2007, 2009). Phenylhydrazine reacts with haemoglobin forming bioactive radicals with an un‐bound oxygen being consumed in the reaction (Shetler & Hill, 1985).…”

Section: Mean ±Se Values For Various Variables In Hippoglossus Hippmentioning

confidence: 99%

“…With either type of anaemia (haemorrhagic or haemolytic), the result is a reduction in the oxygen‐carrying capacity of the blood that stimulates erythropoietin transcription through hypoxia‐inducible factor 1 α (HIF‐1 α ). Increases in cardiac output occur, driven by increases in stroke volume and cardiac frequency and aided by cardiac hypertrophy resulting from structural remodelling of the heart at least in phenylhydrazine‐induced anaemia in rainbow trout, Oncorhynchus mykiss (Walbaum 1792), (Simonot & Farrell, 2007, 2009) and cod Gadus morhua L. 1758 (Powell et al , 2011). Bottom dwelling fishes such as pleuronectiformes have been observed with low haematocrits, although the mechanisms by which the fishes may compensate for these effects are unknown.…”

Section: Mean ±Se Values For Various Variables In Hippoglossus Hippmentioning

confidence: 99%

“…With a reduced potential carrying capacity due to significant reductions in haemoglobin and haematocrit as a result of anaemia, the increased ventricular contraction efficiency (as suggested by the change in ventricular shape) and increased ventricular size (increasing stroke volume) are probably compensatory to facilitate enhanced cardiac output. This has been suggested for O. mykiss (Simonot & Farrell, 2007, 2009), although salmonids have a well‐developed coronary circulation to supplement cardiac activity. In winter flounder Psuedopleuronectes americanus (Walbaum 1792), dorsal aortic pressure was reduced under hypoxia in line with reduced cardiac output and heart rate, thereby maintaining systemic vascular resistance (Mendoça & Gamperl, 2010).…”

Section: Mean ±Se Values For Various Variables In Hippoglossus Hippmentioning

confidence: 99%

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Cardiac remodelling of Atlantic halibut Hippoglossus hippoglossus induced by experimental anaemia with phenylhydrazine

Powell

Burke

Dahle

2012

Journal of Fish Biology

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Phenylhydrazine injections (0.3 mg kg(-1) , followed by a second injection of 0.1 mg kg(-1) 7 days later) induced a reproducible and stable anaemia in Atlantic halibut Hippoglossus hippoglossus, reducing the haematocrit and haemoglobin by 70.0 and 75.5%, respectively, over 3 weeks. There were no changes in blood electrolyte or lactate concentrations, although anaemic fish showed a 37.5 and 33.0% increase in cardiac somatic index and ventricular somatic index, respectively, compared with dimethyl sulphur oxide (DMSO) and saline vehicle controls. Changes in cardiac somatic indices did not correlate with the ratio of ventricular length:height and length:width did correlate with haematocrit and haemoglobin indicating that changes in cardiac shape may occur as a function of anaemic hypoxemia.

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Coronary vascular volume remodelling in rainbow troutOncorhynchus mykiss

Cited by 11 publications

References 47 publications

The effect of ploidy and incubation temperature on survival and the prevalence of aplasia of the septum transversum in Atlantic salmon, Salmo salar L

The effect of ploidy and incubation temperature on survival and the prevalence of aplasia of the septum transversum in Atlantic salmon, Salmo salar L

Cardiac remodelling, blood chemistry, haematology and oxygen consumption of Atlantic cod, Gadus morhua L., induced by experimental haemolytic anaemia with phenylhydrazine

Cardiac remodelling of Atlantic halibut Hippoglossus hippoglossus induced by experimental anaemia with phenylhydrazine

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