Coronavirus 2019-nCoV: A brief perspective from the front line

Han, Qingmei; Lin, Qingqing; Jin, Shuwen; You, Liangshun

doi:10.1016/j.jinf.2020.02.010

Cited by 280 publications

(290 citation statements)

References 35 publications

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“…The most recent statistics of the World Health Organization (WHO) attests that SARS-CoV-2 has already infected nearly 635,000 persons around the world, causing over 30,000 deaths [8]. These numbers are inevitably destined to grow as definitive vaccines and cures for COVID-19 are unlikely to be identified soon [9]. As such, a combination of contact tracing and social isolation seems to be the most effective strategy to control the COVID-19 outbreak [10], as this strategy will be effective for flattening the curve of new infections due to human-to-human transmission, limiting morbidity, mortality and the ensuing surge of demand on healthcare system.…”

Section: Introductionmentioning

confidence: 99%

Health risks and potential remedies during prolonged lockdowns for coronavirus disease 2019 (COVID-19)

et al. 2020

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As coronavirus disease 2019 (COVID-19) pandemic continues, an increasing number of countries and territories are adopting restrictive measures based on physical ("social") distancing, aimed at preventing human-to-human transmission and thereby limiting virus propagation. Nationwide lockdowns, encompassing mass quarantine under stay-at-home ordinances, have already been proven effective to contain the COVID-19 outbreak in some countries. Nevertheless, a prolonged homestay may also be associated with potential side effects, which may jeopardize people's health and thus must be recognized and mitigated in a way without violating local ordinances. Some of the most important undesirable consequences of prolonged homestay such as physical inactivity, weight gain, behavioral addiction disorders, insufficient sunlight exposure and social isolation will be critically addressed in this article, which also aims to provide some tentative recommendations for the alleviation of side effects.

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Section: Introductionmentioning

confidence: 99%

Health risks and potential remedies during prolonged lockdowns for coronavirus disease 2019 (COVID-19)

et al. 2020

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“…Coronaviruses including SARS-CoV-2, SARS, and MERS were proved to have the potential ability to lead to significant and peculiar destructive host immune response that is related to severe lung damage. Researches exhibited the lung impairment is mostly observed in patients in a critical state, linked to a cytokine storm, marked by raised levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-12, TNF, IFN-γ), as well as of anti-inflammatory cytokines (IL-4, IL-10, IL-13, TGF-β) [12,[19][20][21][22][23][24][25] .…”

Section: Discussionmentioning

confidence: 99%

A Mini Review on Current Clinical and Research Findings for Children Suffering from COVID-19

Xiao

Qian

Xie

et al. 2020

Preprint

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Background: As the novel coronavirus triggering COVID-19 has broken out in Wuhan, China and spread rapidly worldwide, it threatens the lives of thousands of people and poses a global threat on the economies of the entire world. However, infection with COVID-19 is currently rare in children. Objective: To discuss the latest findings and research focus on the basis of characteristics of children confirmed with COVID-19, and provide an insight into the future treatment and research direction. Methods: We searched the terms "COVID-19 OR coronavirus OR SARS-CoV-2" AND "Pediatric OR children" on PubMed, Embase, Cochrane library, NIH, CDC, and CNKI. The authors also reviewed the guidelines published on Chinese CDC and Chinese NHC. Results: We included 25 published literature references related to the epidemiology, clinical manifestation, accessary examination, treatment, and prognosis of pediatric patients with COVID-19. Conclusion: The numbers of children with COVID-19 pneumonia infection are small, and most of them come from family aggregation. Symptoms are mainly mild or even asymptomatic, which allow children to be a risk factor for transmission. Thus, strict epidemiological history screening is needed for early diagnosis and segregation. This holds especially for infants, who are more susceptible to infection than other age groups in pediatric age, but have most likely subtle and unspecific symptoms. They need to be paid more attention to. CT examination is a necessity for screening the suspected cases, because most of the pediatric patients are mild cases, and plain chest X-ray do not All rights reserved. No reuse allowed without permission. : medRxiv preprint usually show the lesions or the detailed features. Therefore, early chest CT examination combined with pathogenic detection is a recommended clinical diagnosis scheme in children. The risk factors which may suggest severe or critical progress for children are: Fast respiratory rate and/or; lethargy and drowsiness mental state and/or; lactate progressively increasing and/or; imaging showed bilateral or multi lobed infiltration, pleural effusion or rapidly expending of lesions in a short period of time and/or; less than 3 months old or those who underly diseases. For those critical pediatric patients with positive SARS-CoV-2 diagnosis, polypnea may be the most common symptom. For treatment, the elevated PCT seen in children in contrast to adults suggests that the underlying coinfection/secondary infection may be more common in pediatric patients and appropriate antibacterial treatment should be considered. Once cytokine storm is found in these patients, anti-autoimmune or blood-purifying therapy should be given in time. Furthermore, effective isolation measures and appropriate psychological comfort need to be provided timely.

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“…The trophism and pathogenicity of the virus determine its classification to a respective group; α coronaviruses most often cause mild upper respiratory tract infections, β viruses are highly pathogenic and can cause pneumonia and severe respiratory disorders (severe acute respiratory syndrome -SARS, Middle East respiratory syndrome -MERS). β coronaviruses have caused two prior outbreaks of massive respiratory infections in humans -at the turn of 2002 and 2003 in China (SARS) and in 2013 in Saudi Arabia (MERS) [5][6][7].…”

Section: Covid-19 -What Should Anaethesiologists and Intensivists Knomentioning

confidence: 99%

COVID-19 – what should anaethesiologists and intensivists know about it?

Wujtewicz¹,

Dylczyk-Sommer²,

Aszkiełowicz³

et al. 2020

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Over the past three months, the world has faced an unprecedented health hazard. The World Health Organization has announced a pandemic infection with an unknown species of coronavirus called SARS-CoV-2. Spreading mainly through the droplet route, the virus causes mild symptoms in the majority of cases, the most common being: fever (80%), dry cough (56%), fatigue (22%) and muscle pain (7%); less common symptoms include a sore throat, a runny nose, diarrhea, hemoptysis and chills. A life-threatening complication of SARS-CoV-2 infection is an acute respiratory distress syndrome (ARDS), which occurs more often in older adults, those with immune disorders and co-morbidities. Severe forms of the infection, being an indication for treatment in the intensive care unit, comprise acute lung inflammation, ARDS, sepsis and septic shock. The article presents basic information about etiology, pathogenesis and diagnostics (with particular emphasis on the importance of tomocomputer imaging), clinical picture, treatment and prevention of the infection. It goes on to emphasize the specific risks of providing anesthesiology and intensive care services. Due to the fact that effective causal treatment is not yet available and the number of infections and deaths increases day by day, infection prevention and strict adherence to recommendations of infection control organizations remain the basis for fighting the virus.

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Coronavirus 2019-nCoV: A brief perspective from the front line

Cited by 280 publications

References 35 publications

Health risks and potential remedies during prolonged lockdowns for coronavirus disease 2019 (COVID-19)

Health risks and potential remedies during prolonged lockdowns for coronavirus disease 2019 (COVID-19)

A Mini Review on Current Clinical and Research Findings for Children Suffering from COVID-19

COVID-19 – what should anaethesiologists and intensivists know about it?

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