The coronavirus pandemic is more global, dramatic, and unusual than any crisis we have seen in a long time. It has not only seriously threatened human life but also severely impacted the world economy and international relations. Following the pandemic, global affairs as well as state-to-state relationships are witnessing major, even qualitative, changes. The article analyzes the relations of two major powers, the United States of America and China, the two most important players on the world stage in the era of COVID19 and its implication of the world order. The global impact of the coronavirus pandemic poses two interconnected questions: Is this a historic moment when the world will change permanently? Will there be a lasting impact on geopolitics globally? A definite answer to these questions is not yet in sight. However, the emerging political debate on the impact of the pandemic could help bring about clearer predictions about how the world will evolve in the post-Covid-19 period. Key words: Covid-19, pandemic, USA, China, international relations, global order