Coronavirus Disease-19 (COVID-19) Related Acute Stroke Causing Transient Global Amnesia

Ramanathan, Ramnath Santosh; Wachsman, Ari

doi:10.1016/j.jstrokecerebrovasdis.2021.105738

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…In addition, during the pandemic, COVID-19 infection itself, ( Werner et al, 2020 ; Hornick et al, 2022 ), increased stress induced by social distancing, uncertainty concerning the future, and the fear of getting infected could trigger TGA. ( Ramanathan and Wachsman, 2021 ). Interestingly, the potential role of the influenza vaccine in TGA has not yet been studied.…”

Section: Discussionmentioning

confidence: 99%

“…An increased incidence of TGA has been suggested since the beginning of the COVID-19 pandemic, but still has to be confirmed, pertaining to COVID-19 infection itself or the stress induced by the constraints endured by the population. ( Werner et al, 2020 ; Ramanathan and Wachsman, 2021 ; Hornick et al, 2022 ). Yet, the association of TGA with various drugs (e.g.…”

Section: Introductionmentioning

confidence: 99%

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COVID-19 Vaccine-Associated Transient Global Amnesia: A Disproportionality Analysis of the WHO Safety Database

Merino

Gérard

Obberghen³

et al. 2022

Front. Pharmacol.

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Coronavirus disease 2019 (COVID-19) spread rapidly, resulting in a global pandemic for which vaccines were quickly developed. As their safety continues to be monitored, cases of transient global amnesia (TGA) following mRNA vaccination with elasomeran have been reported. TGA is characterized by sudden onset of anterograde amnesia with preservation of other cognitive functions and resolution within 24 h. We aimed to investigate the potential link of TGA with COVID-19 vaccines. We queried the World Health Organization VigiBase® for all reports of “Transient global amnesia”, up to 6 December 2021. Disproportionality analysis relied on the Reporting Odds Ratio (ROR) with its 95% Confidence Interval (CI) and the Information Component (IC). A positive lower end of the 95% CI of the IC (IC025) is used to statistically detect a signal. Of all TGA cases, 289 were associated with a COVID-19 vaccine, representing the most frequent association. Tozinameran was mostly represented (147, 50.8%), followed by AZD1222 (69, 23,8%), elasomeran (60, 20.8%), and JNJ-78436735 (12, 4.2%). With an IC025 > 0, COVID-19 vaccines showed a significant ROR (5.1; 95%CI 4.4–6.0). Tozinameran reached the strongest ROR (4.6; 95%CI 3.9–5.0), followed by elasomeran (4.4; 95%CI 3.4–6.0), AZD1222 (3.8; 95%CI 3.0–5.0), and JNJ-78436735 (3.7; 95%CI 2.1–6.0). Our analysis of COVID-19 vaccines-related TGA reports shows significant disproportionality. Cerebrovascular, inflammatory, or migrainous mechanisms may underlie this association. Yet, numerous confounding factors cannot be tackled with this approach, and causality cannot be ascertained. The identification of this trigger of TGA may help the clinician in his etiological research.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

COVID-19 Vaccine-Associated Transient Global Amnesia: A Disproportionality Analysis of the WHO Safety Database

Merino

Gérard

Obberghen³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Adenovirus itself can combine with platelet, leading to thrombosis [ 9 ]. Also, viral spike glycoprotein binds to angiotensin-converting enzyme 2 (ACE2), resulting in ACE2 downregulation, which in turn overactivated the classical renin-angiotensin system (RAS) and activates the alternative RAS signal in the brain, resulting in a cascade of coagulopathy and inflammation [ 6 ]. The true mechanism is uncertain, but the vaccine’s coagulopathy seemed hypothesized.…”

Section: Discussionmentioning

confidence: 99%

“…TGA after nasopharyngeal swab for COVID-19 screening [ 4 ] and TGA as a first manifestation of COVID-19 were reported [ 5 ]. Two cases of TGA-presenting stroke after COVID-19 infection have been also reported [ 6 ]. However, TGA after COVID-19 vaccination has not been reported, so we herein describe such a case.…”

Section: Introductionmentioning

confidence: 99%