Coronavirus disease 2019 during pregnancy: a systematic review of reported cases

Gatta, Anna Nunzia Della; Rizzo, Roberta; Pilu, Gianluigi; Simonazzi, Giuliana

doi:10.1016/j.ajog.2020.04.013

Cited by 263 publications

(241 citation statements)

References 20 publications

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“…Findings from the current review were contrary to those reported by Gatta and colleagues 7 , from their review which involved 51 pregnant women, where 3 pregnancies were ongoing, among 48 remained pregnancies, 46 gave birth by cesarean delivery and 2 gave birth vaginally, there was no evidence of vertical transmission recorded in all reported births. In this study, all studies were retrospective and conducted in the same country, China.…”

Section: Discussioncontrasting

confidence: 99%

“…Like other infectious diseases, pregnant women continue to be vulnerable to COVID-19 4 . Literature has reported the possible potential implications of COVID-19 in pregnancy but the debate on a possible vertical transmission is still ongoing 4,5 . Few studies have associated the potential in uence of COVID-19 infection from an infected pregnant woman to her fetus or newborn, these include the possibility of miscarriages, preterm delivery and neonatal infections 6,7 .…”

Section: Introductionmentioning

confidence: 99%

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A systematic review of vertical transmission and antibodies against SARS-CoV-2 among infants born to mothers with COVID-19

Bwire¹,

Njiro²,

Mwakawanga³

et al. 2020

Preprint

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Amidst the Coronavirus Disease 2019 (COVID-19) pandemic, evidence on vertical transmission and natural passive immunity among the newborns exposed to COVID-19 is scanty and varies. This pose a challenge on preventive interventions for the newborns. We conducted a systematic review to first, determine the likelihood of vertical transmission among COVID-19 exposed infants and second, determine whether antibodies against Severe Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/ COVID-19 virus exist among COVID-19 vertically exposed but negative infants. This review registered in PROSPERO searched evidence from PubMed/ MEDLINE and Google Scholar, among others. About 517 studies were retrieved, where only 33 articles (5.8%) qualified for final analysis. A total of 205 infants born to SARS-CoV-2 positive mothers were pooled from 33 eligible studies. Overall, 6.3% (13/205; 95%CI: 3.0%-9.7%) of the infants tested positive for COVID-19 virus at birth. Of 33 eligible studies, 6 studies (18.8%) reported about IgG/IgM against SARS-CoV-2. Anti-SARS-CoV-2 IgG/IgM were detected in 90% (10/11; 95%CI: 73.9%-107.9%) of infants who had no COVID-19 but vertically exposed. In conclusion, the current evidence revealed a low possibility of vertical transmission of COVID-19 while antibodies against SARS-CoV-2 were detected in most of the infants who had no COVID-19. Further studies on perinatal outcomes and the magnitude of natural passive immunity in infants born to mothers with COVID-19 are warranted.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A systematic review of vertical transmission and antibodies against SARS-CoV-2 among infants born to mothers with COVID-19

Bwire¹,

Njiro²,

Mwakawanga³

et al. 2020

Preprint

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show abstract

“…Other risk factors for disease severity include older age, chronic kidney disease, chronic obstructive pulmonary disease, immunocompromise, obesity, cardiovascular disease, diabetes mellitus, and possibly asthma, smoking, and hypertension [ 3 ]. There are conflicting data on disease course in pregnancy [ 4 , 5 ], with obesity and gestational diabetes risks for severe infection in pregnant women [ 6 , 7 ]. The purpose of this study was to determine the prevalence and disease course of COVID-19 among pregnant women delivering at John H. Stroger Hospital, a safety net hospital in Chicago, Illinois.…”

Section: Introductionmentioning

confidence: 99%

Coronavirus Disease 2019 in Pregnancy: The Experience at an Urban Safety Net Hospital

et al. 2020

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Shortly after the identification of a novel coronavirus, the coronavirus disease 2019, or COVID-19, a global pandemic was declared. There have been conflicting data about the severity of COVID-19 disease course in pregnant women, with most US data suggesting an increase in severity and increased need for hospitalization and intubation in obstetric patients. In the general population, the disease is more common among racial and ethnic minority populations, and severity is increased with comorbid conditions and obesity. The purpose of this study is to characterize COVID-19 infection in pregnancy in a population of women getting prenatal care at an urban safety-net hospital. Beginning in April, 2020, all women were tested at admission for delivery, and additionally as an outpatient if presenting with COVID-19 symptoms. In three months, there were 208 discrete women tested and 23 (11.1%) who were positive for COVID-19. The incidence of COVID-19 was 5.1% in asymptomatic women being screened upon admission to the hospital. There was a high prevalence of obesity (68.2%) and other comorbid conditions (43.5%) in this population, and all patients were racial/ethnic minorities. Despite these risk factors, the patients uniformly had either mild or asymptomatic disease. No symptomatic patients required hospitalization for their infection. In this population of pregnant women at high risk for severe COVID-19 infection, only mild disease was observed.

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“…In a systematic review of the available literature including six studies with 51 pregnant women, 4 the outcome has been generally favourable for both mothers and fetuses. In their review, women have been most often delivered by caesarean section, and frequently before term gestation.…”

mentioning

confidence: 99%

Do pregnant women have protective immunity against COVID‐19?

Bouchghoul

Vigoureux

2020

BJOG

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Coronavirus disease 2019 during pregnancy: a systematic review of reported cases

Cited by 263 publications

References 20 publications

A systematic review of vertical transmission and antibodies against SARS-CoV-2 among infants born to mothers with COVID-19

A systematic review of vertical transmission and antibodies against SARS-CoV-2 among infants born to mothers with COVID-19

Coronavirus Disease 2019 in Pregnancy: The Experience at an Urban Safety Net Hospital

Do pregnant women have protective immunity against COVID‐19?

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