Coronavirus Disease 2019 in Critically Ill Children: A Narrative Review of the Literature*

Abstract

Coronavirus disease 2019 has spread around the world. In the 3 months since its emergence, we have learned a great deal about its clinical management and its relevance to the pediatric critical care provider. In this article, we review the available literature and provide valuable insight into the clinical management of this disease, as well as information on preparedness activities that every PICU should perform.

COVID-19 Associated Hemophagocytic Lymphohistiocytosis and Coagulopathy: Targeting the Duumvirate

“…Severe lymphopenia, with absolute count of less than 0.6×10 9 /L, was also found to be an important indicator for intensive care support in patients [11]. Lymphopenia in critically ill children is reported to be less common in comparison to adults with COVID-19 [12]. However, clinicians should keep in mind that higher neutrophil count has also been shown to be associated with increased risk of ARDS and death [10].…”

SARS-CoV-2 infections with emphasis on pediatric patients: a narrative review

“…Ong et al 22 called attention to the group of children under one year of age, in whom the occurrence of severe cases of COVID-19 is more frequent than in older children. Lymphopenia, so common in adults (70%) occurs in only 3.5% of children, and the increment of inflammatory markers and cytokines are not so marked, except in the multisystem inflammatory syndrome associated with COVID-19 (MIS-C) cases.…”

Hygiene in der Anästhesie in Zeiten der SARS-CoV-2-Pandemie

“…Allerdings wurde inzwischen auch über einzelne schwere Verläufe berichtet. Dies wird in weiteren Studien beobachtet [3]. Eine außergewöhnlich heftige Freisetzung von virushaltigem Aerosol bei "explosivem Husten oder Niesen" ist zwar denkbar und es kann theoretisch auch über weitere Strecken verteilt bzw.…”