Coronavirus Disease 2019 in Patients With End-Stage Kidney Disease on Hemodialysis in Guatemala

Sosa, Regina; García, Pablo; Cipriano, E.; Hernandez, A.; Hernández, Elmer; Chavez, Paola I.; Manchinelli, Angélica; Morales, Óscar Alberto; Flores, Lori; Romero, Hair J.; Raquec, Yulany; Sapón, Byron F.; Soch, Kevin E.; Anand, Shuchi; Sánchez-Polo, Vicente

doi:10.1016/j.ekir.2021.01.028

Cited by 12 publications

(16 citation statements)

References 27 publications

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“…In relation to BMI, there is a direct association between obesity and greater risk of Covid 19 infection. In the present series, the percentage of overweight was 30.48% and obesity 7.1%, lower than that reported and with no relation to mortality, this is explained because in our population on chronic dialysis obesity is less prevalent than in the general population 15, 18, 26-28 .…”

Section: Discussioncontrasting

confidence: 78%

“…There is evidence that the factors related to greater mortality are age, male sex, comorbidities such as arterial hypertension, diabetes mellitus and obesity, inflammatory markers, and respiratory compromise [25][26][27][28][29][30][31][32] , in the present investigation as well as in a Spanish study, no relationship was found with age, sex and comorbidities 33 .…”

Section: Discussionmentioning

confidence: 47%

“…The baseline Charlson index, which relates long-term mortality to the patient’s comorbidity, was evaluated; at the beginning of hospitalization, it was 3.85 ±1.18 with a 10-year survival of 53.62%, taking into account that the survival rates found 20 and 30 days after hospitalization for Covid 19 infection were 65.3% and 56% respectively, it can be seen that the probability of survival decreases with hospitalization, as also reported by Savino et al 28,30-32 .…”

Section: Discussionmentioning

confidence: 68%

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“Epidemiological profile of patients with stage 5 chronic kidney disease on dialysis with Covid 19 infection in a Public Hospital-Perú”

Justiniano

Munárriz

2021

Preprint

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Introduction: Chronic kidney disease (CKD) in Covid 19 is relevant, however, there are few descriptions and fewer in Peru. Our goal was to describe the epidemiological profile and the factors related to mortality and survival of patients with stage 5 (CKD) on chronic dialysis hospitalized for Covid-19 in a public hospital. Methods: Retrospective case series. Patients with stage 5 CKD, older than 18 years, hospitalized for Covid-19 infection were included. The primary data source was medical records. The clinical and epidemiological profile of the study sample and the factors related to mortality and survival are described. Results: 105 medical records of patients with CKD 5 were evaluated. 57 (54,29%) were male, with a mean age of 58,59 +/- 14,3 years. 84 (80%) patients survived and 21 (20%) died. The main cause of admission to hospitalization was respiratory failure in (80) 76,2%. The hospital stay was 11,76 +/- 7,8 days. In the bivariate analysis: the increase in leukocytes, D dimer, ferritin, CRP, LDH and the decrease in lymphocytes, pH, bicarbonate and PaO2/FiO2 were related to mortality. In the multivariate analysis, only CRP> 10 mg/dl [HR: 10.72 (95% CI 1,4-81,58)] and a PaO2/FiO2 ≤ 150 mmHg [HR: 44,40 (95% CI 5,86-336,06)] they were factors related to poor survival. Conclusions: CRP levels> 10mg/dl and PaO2/FiO2 ≤ 150 mmHg are the main factors related to mortality and poor survival in patients with stage 5 CKD hospitalized for Covid-19. Keywords: Renal Insufficiency, renal dialysis, Coronavirus infections, Covid- 19, survival. (MeSH)

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Section: Discussioncontrasting

confidence: 78%

Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 68%

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“Epidemiological profile of patients with stage 5 chronic kidney disease on dialysis with Covid 19 infection in a Public Hospital-Perú”

Justiniano

Munárriz

2021

Preprint

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“…3,4 In different reports, the lethality from Covid-19 in patients with kidney failure with renal replacement therapy (KFRT) varies from 23% to 27.7%. [5][6][7] We present the epidemiology and major clinical results (hospitalisation and mortality) of patients with KFRT on peritoneal dialysis (PD) who developed Covid-19 in Chile, from the beginning of the pandemic (March 2020) to the start of vaccinations in the country (January 2021). 8…”

Section: Introductionmentioning

confidence: 99%

Survival study and factors associated with mortality in Chilean patients on peritoneal dialysis infected with SARS-CoV-2

Ortiz

Sepúlveda

Torres³

et al. 2022

Perit Dial Int

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The Covid-19 pandemic has been responsible for millions of deaths worldwide. Patients with comorbidities– such as those on peritoneal dialysis (PD)– present higher morbidity and mortality than the general population. We prospectively evaluated all Chilean patients on PD (48 centres) and followed those who had Covid-19 from the beginning of the Covid-19 pandemic in Chile (March 2020) to January 2021 (start of vaccination campaign). We described demographic history, comorbidities, factors related to infection, need for hospitalisation and death due to Covid-19. During the study period, 106 adults on PD were infected by SARS-CoV-2, with a mean age of 53.1 (±16.3) and of which 53.9% were female. From that group, 54.8% required hospitalisation and 24.5% ( n = 26) died due to Covid-19. Most of the patients (63.4%) were infected at home and 22.8% during hospitalisation for other reasons. There was a significant association for Covid-19 mortality with: being ≥60 years old, diabetes, time on PD ≥5 years, need for hospitalisation and hospital-acquired infection. At 90 days of follow-up, all deaths associated to Covid-19 occurred before 40 days. We conclude that patients on PD without Covid-19 vaccination have a high mortality and need for hospitalisation associated to Covid-19. To avoid this negative outcome, it is necessary to intensify strategies to avoid contagion, especially in those ≥60 years old, with diabetes and/or ≥5 years spent on PD.

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“…We have summarized previous studies reporting mortality rate and its predictors reporting in more than 100 ESRD patients (Table 2) 9,12,[17][18][19][20][21][22][23][24][25][26][27][28][29] . The mortality rate was high between 20-32% (mean 25.4%) in a total of 8,370 patients.…”

Section: Predictors Of Mortality In Esrd Patients With Covid-19mentioning

confidence: 99%

Risks and Benefits of Kidney Transplantation during the COVID-19 Pandemic: Transplant or Not Transplant?

et al. 2021

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COVID-19 disease has significantly affected the transplant community by leading to decreased transplant activity and increased waiting list time. As expected, COVID-19 causes substantial mortality in both end-stage renal disease and kidney transplant populations. This is due to underlying chronic kidney disease and a high prevalence of comorbid conditions such as diabetes mellitus, hypertension, and cardiovascular disease in this group. Transplant programs have faced the difficult decision of weighing the risks and benefits of transplantation during the pandemic. On one hand there is a risk of COVID-19 exposure leading to infection while patients are on maximum immunosuppression. Alternatively, there are risks of delaying transplantation, which will increase waitlist-time and may lead to waitlist-associated morbidity and mortality. Cautious and thoughtful selection of both the recipient's and donor's post-transplant management is required during the pandemic to mitigate the risk of morbidity and mortality associated with COVID-19. In this review article we aimed to discuss previous publications related to clinical outcomes of COVID-19 disease in kidney transplant recipients, end-stage renal disease patients on dialysis or on the transplant waiting-list and precautions transplant centers should take in decision making for recipient and donor selection and immunosuppressive management during the pandemic. Nevertheless, transplantation in this milieu does seem to be the correct decision with a careful patient and donor selection with safeguard protocols for infection prevention. Each center should do risk assessment based on their patient's age and medical comorbidities, waitlist time, degree of sensitization, cold ischemia time, status of vaccination, and severity of pandemic in their region.

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Coronavirus Disease 2019 in Patients With End-Stage Kidney Disease on Hemodialysis in Guatemala

Cited by 12 publications

References 27 publications

“Epidemiological profile of patients with stage 5 chronic kidney disease on dialysis with Covid 19 infection in a Public Hospital-Perú”

“Epidemiological profile of patients with stage 5 chronic kidney disease on dialysis with Covid 19 infection in a Public Hospital-Perú”

Survival study and factors associated with mortality in Chilean patients on peritoneal dialysis infected with SARS-CoV-2

Risks and Benefits of Kidney Transplantation during the COVID-19 Pandemic: Transplant or Not Transplant?

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