Coronavirus Disease Pathophysiology: Biomarkers, Potential New Remedies, Comorbidities, Long COVID-19, Post Pandemic Epidemiological Surveillance

Kubiak, Jacek Z.; Kloc, Małgorzata

doi:10.3390/ijms241512236

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…found in the blood of post-COVID patients; the origin of these circulating microclusters is unknown [4]. An increase in the concentration of antimicrobial active proteins (RBP2 and BST2) and MATN2 and COL6A3 proteins involved in extracellular matrix remodeling [5], was also found in these patients. Long-COVID is accompanied by an increase in ACE levels, and this, according to the authors, may induce the development of an aberrant long-term immune response [6].…”

Section: Journal Of Immunology (Issn 2995-861x)mentioning

confidence: 98%

Post-Covid Syndrome - A Model of Pathogenesis

Kazimirskii

2024

immunology

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Post- COVID is characterized by a decrease in the patients’ quality of life, a tendency to hemocoagulation. Symptoms of post- COVID are diverse and difficult to classify. Purpose : Study of neutrophil extracellular traps (NETs) in post-COVID patients to clarify the mechanisms of damage. Patients and methods : Two groups of patients with postCOVID were examined. In the first group (21 patients), COVID-19 treatment was carried out in a hospital, in the second group (20 patients) - on an outpatient clinic. The comparison group consisted of 10 patients with acute appendicitis, the control group consisted of 20 healthy people. Neutrophils were isolated using gradient centrifugation. NETs was visualized using fluorescence microscopy with SYBR Green dye (Evrogen; Russia), which specifically interacts with double-stranded DNA. Purine nitrogenous bases (PNB) were determined by the color reaction method based on their interaction with silver nitric acid.

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Section: Journal Of Immunology (Issn 2995-861x)mentioning

confidence: 98%