Coronavirus infection and immune system: An insight of COVID-19 in cancer patients

Abstract

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Transmission of SARS-CoV-2 in Surgical Smoke during Laparoscopy: A Prospective, Proof-of-concept Study

“…These were tested for two gene targets: ORF1ab and N. According to accumulating data, analyzing the genome of the SARS-CoV-2, ORF and N genes represent the most specific target for its identification [9,10]. ORF1ab is highly presumptive for the presence of SARS-CoV-2; while the N gene might be detected even in other coronavirus infections [1,9,10].…”

“…According to accumulative data regarding analysis of the SARS-CoV-2 genome, the ORF and N genes represent the most specific targets for its detection [9 , 10] . The ORF1ab gene is highly presumptive for the presence of SARS-CoV-2, whereas the N gene might be detected even in other coronavirus infections [1 , 9 , 10] . The amplification curve of the ORF1ab gene suggested that 1 case was positive for SARS-CoV-2, whereas the amplification curve of the N gene suggested a presumptive positive case of SARS-CoV-2 (because the amplification curve of the N gene might be related to another coronavirus infection).…”

“…The amplification curve of the ORF1ab suggested a case positive for SARS-CoV-2; while the amplification curve of N suggested a presumptive positive case of SARS-CoV-2 (since amplification curve of N might be related to another coronavirus infection) . The assay was performed according to the WHO guidelines[1,9, 10].RNA was extracted in a QIAsymphony DSP Virus/pathogen midi kit with (Qiagen N.V., Hilden, Germany) according to the manufacturer's instructions. Sample inactivation was performed with treatment with buffer ATL (Qiagen) and ProteinaseK(Qiagen) followed by 15 min incubation at 56°C.…”

“…On December 31, 2019, in Wuhan, the capital of the province of Hubei in central China, hospitals recorded numerous cases of pneumonia of unknown cause, initially named “novel coronavirus pneumonia.” On January 7, 2020, researchers identified a new coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) in the patients who had become infected, thanks to reverse transcription–polymerase chain reaction (RT-PCR) and next-generation sequencing techniques. On March 11, 2020, the World Health Organization formally declared the coronavirus disease (COVID-19) outbreak a pandemic, and on June 7, 2020, there were 6 799 713 cases of infections and 397 388 deaths worldwide [1] .…”

“…COVID-19 has extremely high transmissibility levels [1] . The infection is mainly transmitted through droplets (≥5 μm in diameter) generated by the respiratory tract of a person who has become infected and expelled at short distances (<1 m), especially when coughing or sneezing, by both patients who are symptomatic and patients who are asymptomatic during the latency period of the disease.…”