Coronavirus (SARS-CoV-2) in Antillean Manatees (Trichechus Manatusmanatus)

Melo, Fábio Lopes de; Bezerra, Bruna M.; Luna, Fábia de Oliveira; Barragan, Nahir Alejandra Navarrete; Loyo, Rodrigo Moraes; Umeed, Rebecca; Lucchini, Karen; Attademo, Fernanda Löffler Niemeyer

doi:10.21203/rs.3.rs-1065379/v1

Cited by 11 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two Antilles manatees ( Trichechus manatus manatus ) were infected with SARS‐CoV‐2 at the National Center for Research and Conservation of Aquatic Mammals in Brazil. However, the animals did not exhibit clinical signs 6,24 . This is the first time that a marine mammal has been infected with SARS‐CoV‐2, and the case of infection in this species has only been reported in Brazil.…”

Section: Natural Infections In Animalsmentioning

confidence: 82%

“…The source of infection in the Antilles manatee is not yet clear, but it may have been infected by SARS‐CoV‐2‐positive staff, by contact with contaminated fomites in the environment. 24 …”

Section: Natural Infections In Animalsmentioning

confidence: 99%

“…This is the first time that a marine mammal has been infected with SARS‐CoV‐2, and the case of infection in this species has only been reported in Brazil. The source of infection in the Antilles manatee is not yet clear, but it may have been infected by SARS‐CoV‐2‐positive staff, by contact with contaminated fomites in the environment 24 …”

Section: Natural Infections In Animalsmentioning

confidence: 99%

See 2 more Smart Citations

SARS‐CoV‐2 and natural infection in animals

Qiu

Liu

Sha

2022

Journal of Medical Virology

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is the causative agent of the novel coronavirus disease (COVID‐19) pandemic, which has caused serious challenges for public health systems worldwide. Due to the close relationship between animals and humans, confirmed transmission from humans to numerous animal species has been reported. Understanding the cross‐species transmission of SARS‐CoV‐2 and the infection and transmission dynamics of SARS‐CoV‐2 in different animals is crucial to control COVID‐19 and protect animal health. In this review, the possible animal origins of SARS‐CoV‐2 and animal species naturally susceptible to SARS‐CoV‐2 infection are discussed. Furthermore, this review categorizes the SARS‐CoV‐2 susceptible animals by families, so as to better understand the relationship between SARS‐CoV‐2 and animals.

show abstract

Section: Natural Infections In Animalsmentioning

confidence: 82%

Section: Natural Infections In Animalsmentioning

confidence: 99%

Section: Natural Infections In Animalsmentioning

confidence: 99%

See 1 more Smart Citation

SARS‐CoV‐2 and natural infection in animals

Qiu

Liu

Sha

2022

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a probable zoonotic origin [1,2]. SARS-CoV-2 infections have been detected in a variety of non-human animals, including domesticated cats [3], white-tailed deer [4], captive tigers [5], certain monkey species [6], Antillean manatees [7] and captive hippopotami [8].…”

Section: Introductionmentioning

confidence: 99%

Beluga whale and bottlenose dolphin ACE2 proteins allow cell entry mediated by spike protein from three variants of SARS-CoV-2

Stone,

Unal,

Romano

et al. 2023

Biol. Lett.

View full text Add to dashboard Cite

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses infect numerous non-human species. Spillover of SARS-CoV-2 into novel animal reservoirs may present a danger to host individuals of these species, particularly worrisome in populations already endangered or threatened by extinction. In addition, emergence in new reservoirs could pose spillback threats to humans, especially in the form of virus variants that further mutate when infecting other animal hosts. Previous work suggests beluga whales ( Delphinapterus leucas ) and bottlenose dolphins ( Tursiops truncatus ) may be at risk owing to their formation of social groups, contact with humans, exposure to contaminated wastewater, and structure of their angiotensin-converting enzyme 2 (ACE2) proteins, which SARS-CoV-2 uses as a cellular receptor. We examined marine-mammal susceptibility to virus infection by challenging 293T cells expressing beluga or dolphin ACE2 with pseudovirions bearing the SARS-CoV-2 spike protein. Beluga and dolphin ACE2 were sufficient to allow cell entry by an early pandemic isolate (Wuhan-Hu-1) and two evolved variants (Delta B.1.617.2 and Omicron BA.1 strains). We conclude that SARS-CoV-2 poses a potential threat to marine mammal reservoirs that should be considered in surveillance efforts.

show abstract

“…However, in mammals (non-humans), studies have focused on the susceptibility of different species to viral infection and their roles in the dissemination of COVID-19 ( Shi et al, 2020 , Tiwari et al, 2020 , Rockx et al, 2020 , Audino et al, 2021 , Mathavarajah et al, 2021a , Mathavarajah et al, 2021b , Gryseels et al, 2021 , Delahay et al, 2021 , Patel et al, 2021 , Melo et al, 2022 ). Although Rhea et al (2021) ) have recently demonstrated that intravenously injected radioiodinated S1 (I-S1) (S1 subunit of Spike protein of SARS-CoV-2) readily crossed the blood-brain barrier in male mice, was taken up by brain regions, and entered the parenchymal brain space, the consequences of this translocation have not been evaluated and therefore remain unknown.…”

Section: Introductionmentioning

confidence: 99%