Coronavirus Spectrum Infections (COVID-19, MERS, SARS) in Cancer Patients: A Systematic Review of the Literature

Knisely, Anne; Wu, Jy S.; Kaplan, Samantha; Zhou, Zhen; Melamed, Alexander; Tergas, Ana I.; Clair, Caryn M. St.; Hou, June Y.; Khoury‐Collado, Fady; Huang, Yolanda Y.; Hershman, Dawn L.; Wright, Jason D.

doi:10.1080/07357907.2020.1809668

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…COVID‐19 infection anxiety was measured using a scale adapted from the SARS infection anxiety scale developed and validated during the outbreak of SARS (Cheng & Ng, 2006), a disease belonging to the same atypical coronavirus spectrum as COVID‐19 (e.g., Knisely et al., 2020). The scale's items were adapted from the state anxiety scale of the State‐Trait Anxiety Inventory Form X1 (Spielberger et al., 1970) to refer to an epidemic context.…”

Section: Methodsmentioning

confidence: 99%

Maladaptive coping with the infodemic and sleep disturbance in the COVID‐19 pandemic

Cheng

Ebrahimi

Lau

2020

Journal of Sleep Research

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COVID‐19 is caused by a novel virus with an unknown aetiology. People across the globe are dealing with not only a health crisis but also an ‘infodemic’, a term coined by the World Health Organization to refer to the avalanche of contradictory information that is arousing widespread confusion and anxiety. This study aimed to examine the prevalence of anxiety and sleep disturbance at the early stage of the pandemic, and unveil the information coping process underlying differential susceptibility to COVID‐19 infection anxiety and sleep disturbance. The participants were 1,270 adults (47% men, M age = 42.82) from the UK and US who completed initial (Time 1) and follow‐up (Time 2) surveys from 16 to 22 March and 18 to 24 May 2020, respectively. The prevalence of probable clinically relevant anxiety was 61% and 45% at the first and second time points, and more than half of the participants in this anxiety group also reported mild to severe sleep disturbance. Moreover, 41% of the participants perceived themselves as not having enough COVID‐19‐related information and reported higher levels of COVID‐19 infection anxiety and sleep disturbance over time than those who perceived themselves as having enough of such information. Moderated mediation analysis identified two groups who were more vulnerable to both psychological problems: high blunters who sought COVID‐19‐related information online more frequently and high monitors who sought such information offline less frequently. These findings highlight the importance of a good match between information coping style and strategy deployment in dealing with an infodemic surrounding a novel disease.

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Section: Methodsmentioning

confidence: 99%

Maladaptive coping with the infodemic and sleep disturbance in the COVID‐19 pandemic

Cheng

Ebrahimi

Lau

2020

Journal of Sleep Research

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“…A recent study that investigated clinical manifestations of COVID-19, reported that cancer patients had a 3.5-fold increase in the risk of morbidity and an increased risk of severe infection compared to non-cancer patients 41 . In addition to this, according to one comprehensive study, authors reported that cancer patients who have encountered severe acute respiratory syndrome virus (SARS or SARS-CoV-1), Middle East Respiratory Syndrome (MERS) virus, and SARS-CoV-2 have a higher risk of severe complications and death 44 . In general, patients with cancer may be much more vulnerable to SARS-CoV-2 infection 45 .…”

Section: Introductionmentioning

confidence: 99%

Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers

Temena

Acar

2022

Sci Rep

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Besides typical respiratory symptoms, COVID-19 patients also have gastrointestinal symptoms. Studies focusing on the gastrointestinal tumors derived from gastrointestinal tissues have raised a question whether these tumors might express higher levels of SARS-CoV-2 associated genes and therefore patients diagnosed with GI cancers may be more susceptible to the infection. In this study, we have analyzed the expression of SARS-CoV-2 associated genes and their co-expressions in gastrointestinal solid tumors, cancer cell lines and patient-derived organoids relative to their normal counterparts. Moreover, we have found increased co-expression of TMPRSS2-TMPRSS4 in gastrointestinal cancers suggesting that SARS-CoV-2 viral infection known to be mediated by this protease pair might facilitate the effects of viral infection in GI cancer patients. Further, our findings also demonstrate that TRIM31 expression is upregulated in gastrointestinal tumors, while the inhibition of TRIM31 significantly altered viral replication and viral processes associated with cellular pathways in gastrointestinal cancer samples. Taken together, these findings indicate that in addition to the co-expression of TMPRSS2-TMPRSS4 protease pair in GI cancers, TRIM31 expression is positively correlated with this pair and TRIM31 may play a role in providing an increased susceptibility in GI cancer patients to be infected with SARS-CoV-2 virus.

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“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus of the family Coronaviridae, was identified after the outbreak of the COVID-19 pandemic [ 6 ]. Other coronaviruses such as Middle East Respiratory Syndrome-related coronavirus in 2012 and Severe Acute Respiratory Syndrome coronavirus (SARS, also known as SARS-CoV-1) in 2002 have led to massive epidemics across certain continents, and have especially impacted cancer patients [ 7 , 8 ]. Given the increased incidence rate of SARS-CoV-2, it is likely to co-exist with humans for a long time, like influenza.…”

Section: Introductionmentioning

confidence: 99%

Prognostic and immunological value of ATP6AP1 in breast cancer: implications for SARS-CoV-2

Wang

Liu

Zhang

2021

Aging

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Abnormal ATPase H+ Transporting Accessory Protein 1 ( ATP6AP1 ) expression may promote carcinogenesis. We investigated the association of ATP6AP1 with breast cancer (BC) and COVID-19. The Oncomine, Gene Expression Profiling Interactive Analysis, Human Protein Atlas and Kaplan-Meier plotter databases were used to evaluate the expression and prognostic value of ATP6AP1 in BC. ATP6AP1 was upregulated in BC tissues, and higher ATP6AP1 expression was associated with poorer outcomes. Data from the Tumor Immune Estimation Resource, Tumor-Immune System Interaction Database and Kaplan-Meier plotter indicated that ATP6AP1 expression correlated with immune infiltration, and that its prognostic effects in BC depended on tumor-infiltrating immune cell subtype levels. Multiple databases were used to evaluate the association of ATP6AP1 with clinicopathological factors, assess the mutation and methylation of ATP6AP1 , and analyze gene co-expression and enrichment. The ATP6AP1 promoter was hypomethylated in BC tissues and differentially methylated between different disease stages and subtypes. Data from the Gene Expression Omnibus indicated that ATP6AP1 levels in certain cell types were reduced after SARS-CoV-2 infections. Ultimately, higher ATP6AP1 expression was associated with a poorer prognosis and with higher or lower infiltration of particular immune cells in BC. BC patients may be particularly susceptible to SARS-CoV-2 infections, which may alter their prognoses.

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Coronavirus Spectrum Infections (COVID-19, MERS, SARS) in Cancer Patients: A Systematic Review of the Literature

Cited by 5 publications

References 35 publications

Maladaptive coping with the infodemic and sleep disturbance in the COVID‐19 pandemic

Maladaptive coping with the infodemic and sleep disturbance in the COVID‐19 pandemic

Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers

Prognostic and immunological value of ATP6AP1 in breast cancer: implications for SARS-CoV-2

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