Corpora amylacea in the neocortex in patients with temporal lobe epilepsy and focal cortical dysplasia

Estupiñán-Díaz, Bárbara; Chacón, Lilia María Morales; García-Maeso, I; Pedré, Lourdes Lorigados; Báez-Martín, Margarita Minou; García-Navarro, M.E.; Trápaga-Quincoses, O; Cordero, Nelson Quintanal; Prince-López, J.; Busto, J.E. Bender-del

doi:10.1016/j.nrleng.2013.06.014

Cited by 8 publications

(8 citation statements)

References 20 publications

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“…We combined LM with 3D EM approaches, including correlative SEM/TEM characterization of CA at the nanometer level. Such ultrastructural studies are essential to understand the biological origin of cerebral CA and their relevance to aging and certain disease states that involve the sequestration of toxic cellular metabolites 36–38 .…”

Section: Introductionmentioning

confidence: 99%

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles

Navarro

Genoud

Castaño-Díez

et al. 2018

Sci Rep

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Corpora amylacea are cell-derived structures that appear physiologically in the aged human brain. While their histological identification is straightforward, their ultrastructural composition and microenvironment at the nanoscale have remained unclear so far, as has their relevance to aging and certain disease states that involve the sequestration of toxic cellular metabolites. Here, we apply correlative serial block-face scanning electron microscopy and transmission electron tomography to gain three-dimensional insight into the ultrastructure and surrounding microenvironment of cerebral Corpora amylacea in the human brainstem and hippocampal region. We find that cerebral Corpora amylacea are composed of dense labyrinth-like sheets of lipid membranes, contain vesicles as well as morphologically preserved mitochondria, and are in close proximity to blood vessels and the glymphatic system, primarily within the cytoplasm of perivascular glial cells. Our results clarify the nature of cerebral Corpora amylacea and provide first hints on how they may arise and develop in the aging brain.

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Section: Introductionmentioning

confidence: 99%

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles

Navarro

Genoud

Castaño-Díez

et al. 2018

Sci Rep

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“…They typically appear in localized areas, or multifocally throughout the subpial, subependymal, and perivascular space. Although FCD may well have caused long-standing epilepsy, a high-intensity band on T2W/FLAIR was likely to reflect an unusual accumulation of corpora amylacea in the subpial and subcortical area that was may be due to the secondary changes following intractable epilepsy (8)(9)(10).…”

Section: Discussionmentioning

confidence: 99%

Case report: The origin of transmantle-like features

Matsuo¹,

Fujimoto²,

Komori³

et al. 2022

Front. Radio

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The transmantle sign is considered to be a magnetic resonance imaging feature specific to patients with type II focal cortical dysplasia; however, this sign can be difficult to distinguish from other pathologies, such as a radial-oriented white matter band in tuberous sclerosis. Here, we report a case showing a high-intensity area on T2-weighted and fluid-attenuated inversion recovery images extending from the ventricle to the cortex associated with atypical histopathological findings containing corpora amylacea. This case demonstrates that some instances of transmantle signs may be due to corpora amylacea accumulation.

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“…Since 1837 when CoA were first described by Purkinje, various hypotheses have been proposed regarding the origin of CoA 3 – 5 . In the brain, CoA have been associated with various conditions, such as normal ageing, hippocampal sclerosis, temporal lobe epilepsy, multiple sclerosis, Alzheimer’s disease (AD) and Parkinson’s disease 1 , 6 – 8 . CoA are rarely seen in younger human brains, while increased numbers can be detected after the fourth decade of life 1 ; and they are reported to become larger, although this has not been confirmed with quantitative measurements 1 .…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of size and regional distribution of corpora amylacea in the hippocampal formation of obstructive sleep apnoea patients

Owen

Gíslason

et al. 2021

Sci Rep

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Corpora amylacea (CoA) are spherical aggregates of glucose polymers and proteins within the periventricular, perivascular and subpial regions of the cerebral cortex and the hippocampal cornu ammonis (CA) subfields. The present study quantified the distribution of CoA in autopsied hippocampi of patients with obstructive sleep apnoea (OSA) using ethanolamine-induced fluorescence. CoA were observed in 29 of 30 patients (96.7%). They were most abundant in periventricular regions (wall of lateral ventricle, alveus, fimbria and CA4), rarely found in the CA3 and CA1, and undetectable in the CA2 or subiculum. A spatiotemporal sequence of CoA deposition was postulated, beginning in the fimbria and progressively spreading around the subpial layer until they extended medially to the wall of the lateral ventricle and laterally to the collateral sulcus. This ranked CoA sequence was positively correlated with CoA packing density (count and area fraction) and negatively correlated with CoA minimum diameters (p < 0.05). Although this sequence was not correlated with age or body mass index (BMI), age was positively correlated with the mean and maximum diameters of CoA. These findings support the view that the spatiotemporal sequence of CoA deposition is independent of age, and that CoA become larger due to the accretion of new material over time.

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Corpora amylacea in the neocortex in patients with temporal lobe epilepsy and focal cortical dysplasia

Cited by 8 publications

References 20 publications

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles

Case report: The origin of transmantle-like features

Quantitative analysis of size and regional distribution of corpora amylacea in the hippocampal formation of obstructive sleep apnoea patients

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